ArticleMedical decision making : an international journal of the Society for Medical Decision Making2018
Discrete Event Simulation for Decision Modeling in Health Care: Lessons from Abdominal Aortic Aneurysm Screening.
Article in Medical decision making : an international journal of the Society for Medical Decision Making, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers, 1 of them a synthesis that pooled it.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
15 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Application of Discrete Event Simulation Models for COPD Management: A Systematic Review.International journal of chronic obstructive pulmonary disease · 2025Pooled it
- A Tutorial on Discrete Event Simulation Models Using a Cost-Effectiveness Analysis Example in R.Medical decision making : an international journal of the Society for Medical Decision Making · 2026Article
- In Silico Evaluation of Algorithm-Based Clinical Decision Support Systems: Protocol for a Scoping Review.JMIR research protocols · 2025Article
- Effectiveness and Cost-Effectiveness of Survivorship Care for Survivors of Hodgkin Lymphoma (INSIGHT Study): Protocol for a Multicenter Retrospective Cohort Study With a Quasi-Experimental Design.JMIR research protocols · 2024Article
- A decision support tool with health economic modelling for better management of DVT patients.Health economics review · 2022Article
- Planning for resilience in screening operations using discrete event simulation modeling: example of HPV testing in Peru.Implementation science communications · 2022Article
- Optimal cholesterol treatment plans and genetic testing strategies for cardiovascular diseases.Health care management science · 2021Article
- Real-World Cost-Effectiveness of Late Time Window Thrombectomy for Patients With Ischemic Stroke.Frontiers in neurology · 2021Article
- Modelling the impact of changes to abdominal aortic aneurysm screening and treatment services in England during the COVID-19 pandemic.PloS one · 2021Article
- Application of DMAIC Cycle and Modeling as Tools for Health Technology Assessment in a University Hospital.Journal of healthcare engineering · 2021Article
- Salvage use of tissue plasminogen activator (tPA) in the setting of acute respiratory distress syndrome (ARDS) due to COVID-19 in the USA: a Markov decision analysis.World journal of emergency surgery : WJES · 2020Article
- Agile Six Sigma in Healthcare: Case Study at Santobono Pediatric Hospital.International journal of environmental research and public health · 2020Article
- Improving the Efficiency of an Emergency Department Based on Activity-Relationship Diagram and Radio Frequency Identification Technology.International journal of environmental research and public health · 2019Article
- Analysis of clinical benefit, harms, and cost-effectiveness of screening women for abdominal aortic aneurysm.Lancet (London, England) · 2018Article
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Authors and funding
7 authors.
Funding
Abstract
Markov models are often used to evaluate the cost-effectiveness of new healthcare interventions but they are sometimes not flexible enough to allow accurate modeling or investigation of alternative scenarios and policies. A Markov model previously demonstrated that a one-off invitation to screening for abdominal aortic aneurysm (AAA) for men aged 65 y in the UK and subsequent follow-up of identified AAAs was likely to be highly cost-effective at thresholds commonly adopted in the UK (£20,000 to £30,000 per quality adjusted life-year). However, new evidence has emerged and the decision problem has evolved to include exploration of the circumstances under which AAA screening may be cost-effective, which the Markov model is not easily able to address. A new model to handle this more complex decision problem was needed, and the case of AAA screening thus provides an illustration of the relative merits of Markov models and discrete event simulation (DES) models. An individual-level DES model was built using the R programming language to reflect possible events and pathways of individuals invited to screening v. those not invited. The model was validated against key events and cost-effectiveness, as observed in a large, randomized trial. Different screening protocol scenarios were investigated to demonstrate the flexibility of the DES. The case of AAA screening highlights the benefits of DES, particularly in the context of screening studies.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.