ArticleCaries research2020
Toward Preventing Enamel Hypoplasia: Modeling Maternal and Neonatal Biomarkers of Human Calcium Homeostasis.
Article in Caries research, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers, 2 of them syntheses that pooled it.
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Who cites it
14 citing papers in PubMed, 2 syntheses or guidelines pooled it, 29 citations in OpenAlex.
- Are low serum levels of Vitamin D associated with dental developmental defects in primary teeth? A systematic review.Evidence-based dentistry · 2024Pooled it
- Associations of Prenatal Vitamin D status with Oral Health in Offspring: A Systematic Review.Oral health & preventive dentistry · 2022Pooled it
- Generalized Developmental Enamel Hypoplasia of the Permanent Dentition Associated with Early Childhood Vitamin D Deficiency Rickets: A Case Report.Dentistry journal · 2026Article
- Vitamin D Levels During Pregnancy and Dental Caries in Offspring.JAMA network open · 2025Article
- From cultural dispositions to biological dimensions: a narrative review on the synergy between oral health and vitamin D through the lens of Indian habitus.Frontiers in oral health · 2025Review
- Influences of Maternal Nutrition and Lifestyle Factors on Early Childhood Oral Health: A Systematic Review of Mechanisms and Intervention Strategies.Children (Basel, Switzerland) · 2024Review
- Bayesian modeling of spatially differentiated multivariate enamel defects of the children's primary maxillary central incisor teeth.BMC medical research methodology · 2024Article
- Predictors of Developmental Defects of Enamel in Primary Maxillary Central Incisors Using Bayesian Model Selection.Caries research · 2024Article
- Association between Malnutrition and Dental Caries in Iraqi Kurdish Children.Dentistry journal · 2023Article
- Applications of Optical Coherence Tomography in the Diagnosis of Enamel Defects.Diagnostics (Basel, Switzerland) · 2022Article
- Factors and Mechanisms Involved in Acquired Developmental Defects of Enamel: A Scoping Review.Frontiers in pediatrics · 2022Article
- Melatonin-Medicated Neural JNK3 Up-Regulation Promotes Ameloblastic Mineralization.Frontiers in cell and developmental biology · 2021Article
- Vitamin D Status and Its Influence on the Health of Preschool Children in Hangzhou.Frontiers in public health · 2021Article
- Vitamin D Deficiency and Oral Health: A Comprehensive Review.Nutrients · 2020Review
Corrections and comments
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
Abstract
aimThe aim of this study was to assess biomarkers of calcium homeostasis and tooth development, in mothers during pregnancy and their children at birth, for enamel hypoplasia (EH) in the primary maxillary central incisor teeth.
methodsBayesian methodology was used for secondary data analyses from a randomized, controlled trial of prenatal vitamin D3 supplementation in healthy mothers (N = 350) and a follow-up study of a subset of the children. The biomarkers were serum calcium (Ca), phosphorus (P), intact parathyroid hormone (iPTH), total circulating 25-dihydroxyvitamin D (25(OH)D), and 1,25-dihydroxyvitamin D (1,25(OH)2D). The maternal biomarkers were assayed monthly during pregnancy, and the child's biomarkers were derived from cord blood. Digital images of the child's 2 teeth were scored for EH using Enamel Defects Index criteria for each of the incisal, middle, and cervical regions for an EH extent score.
resultsThe child EH prevalence was 41% (60/145), with most defects present in the incisal and middle tooth regions. Cord blood iPTH and 1,25(OH)2D levels were significantly associated with EH extent after controlling for maternal factors. For every 1 pg/mL increase in cord blood iPTH, the EH extent decreased by approximately 6%. For every 10 pg/mL increase in cord blood 1,25(OH)2D, the EH extent increased by almost 30% (holding all other terms constant and adjusting for subject-level heterogeneity). The relationship between maternal 25(OH)D and maternal mean iPTH varied significantly by EH extent.
conclusionThe results suggest possible modifiable relationships of maternal and neonatal factors of calcium homeostasis during pregnancy and at birth for EH, contributing to the frontier of knowledge regarding sound tooth development for dental caries prevention.
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