Evidence map›Paper›PMID 31665707›Full record

ArticleJournal of neural engineering2020

Optimizing selective stimulation of peripheral nerves with arrays of coils or surface electrodes using a linear peripheral nerve stimulation metric.

Mathias Davids, Bastien Guérin, Valerie Klein, Martin Schmelz, Lothar R Schad, Lawrence L Wald

Abstract read
In one paragraph

Article in Journal of neural engineering, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Mathias DavidsA A Martinos Center for Biomedical Imaging, Department of Radiology, Massachusetts General Hospital, Charlestown, Massachusetts, United States of America.ORCID 0000-0003-0217-9123
Bastien GuérinA A Martinos Center for Biomedical Imaging, Department of Radiology, Massachusetts General Hospital, Charlestown, Massachusetts, United States of America.ORCID 0000-0002-4746-0886
Valerie KleinA A Martinos Center for Biomedical Imaging, Department of Radiology, Massachusetts General Hospital, Charlestown, Massachusetts, United States of America.
Martin SchmelzDepartment of Anesthesiology, Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany.
Lothar R SchadComputer Assisted Clinical Medicine, Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany.
Lawrence L WaldA A Martinos Center for Biomedical Imaging, Department of Radiology, Massachusetts General Hospital, Charlestown, Massachusetts, United States of America.ORCID 0000-0001-8278-6307

Funding

MRI CORTICOGRAPHY: DEVELOPING NEXT GENERATION MICROSCALE HUMAN CORTEX MRI SCANNERU01EB025162 · NIBIB · UNIVERSITY OF CALIFORNIA BERKELEY · PI FEINBERG, DAVID ALAN, LIU, CHUNLEI · 2017 to 2021
$13.4M
A magnetic particle imager (MPI) for functional brain imaging in humansU01EB025121 · NIBIB · MASSACHUSETTS GENERAL HOSPITAL · PI WALD, LAWRENCE L · 2017 to 2022
$6.1M
Mitigation of peripheral nerve stimulation (PNS) in MRIR01EB028250 · NIBIB · MASSACHUSETTS GENERAL HOSPITAL · PI Bastien Guerin · 2020 to 2026
$3.6M
Neuroimaging of deep brain stimulation patients using safe MRI excitationsR00EB019482 · NIBIB · MASSACHUSETTS GENERAL HOSPITAL · PI GUERIN, BASTIEN · 2017 to 2019
$747k
NIBIB NIH HHS R00 EB019482NIBIB NIH HHS R01 EB028250NIBIB NIH HHS U01 EB025121NIBIB NIH HHS U01 EB025162
6 · The paper itself

Abstract

objectiveWe present a PNS oracle, which solves these computation time and linearity problems and is, therefore, well-suited for fast optimization of voltage distributions in contact electrode arrays and current drive patterns in non-contact magnetic coil arrays. APPROACH: The PNS oracle metric for a nerve fiber is computed from an electric field map using only linear operations (projection, differentiation, convolution, scaling). Due to its linearity, this PNS metric can be precomputed for a set of coil or electrode segments, allowing rapid PNS prediction and comparison of any possible coil or electrode stimulation configuration constructed from this set. The PNS oracle is closely related to the classical activating function and modified driving functions but is adjusted to better correlate with full neurodynamic modeling of myelinated mammalian nerves. MAIN

resultsWe validated the PNS oracle in three MRI gradient coils and two body models and found good correlation between the PNS oracle and the full neurodynamic modeling approach (R SIGNIFICANCE: Peripheral nerve stimulation (PNS) by electromagnetic fields can be accurately simulated using coupled electromagnetic and neurodynamic modeling. Such simulations are slow and non-linear in the electric field, which makes it difficult to iteratively optimize coil and electrode configurations or drive patterns aiming to avoid PNS or to initiate it for therapeutic purposes.

Indexed as

Databases, FactualElectromagnetic FieldsElectrodesFemaleHumansMalePeripheral NervesTranscutaneous Electric Nerve Stimulation

Identifiers

PMID31665707
PMCPMC7549543

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.