Evidence map›Paper›PMID 31665635›Full record

ArticleCell reports2019

Transcriptional Signature Derived from Murine Tumor-Associated Macrophages Correlates with Poor Outcome in Breast Cancer Patients.

Sander Tuit, Camilla Salvagno, Theodore S Kapellos, Cheei-Sing Hau, Lea Seep, Marie Oestreich, Kathrin Klee, Karin E de Visser, Thomas Ulas, Joachim L Schultze

Open access · goldAbstract read
In one paragraph

Article in Cell reports, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.

0numbers the graph read from it
0cells of the map it votes in
22citing papers in PubMed
2.5field-weighted citation impact, top 10% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

22 citing papers in PubMed, 43 citations in OpenAlex.

  1. Trial
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  7. Application of Cyclodextrin for Cancer Immunotherapy.Molecules (Basel, Switzerland) · 2023
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  17. Modulation of Host Immune Response duringFrontiers in immunology · 2021
    Article
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  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 3 institutions in 2 countries.

Sander TuitGenomics and Immunoregulation, LIMES Institute, University of Bonn, 53113 Bonn, Germany; Department of Anatomy and Embryology, Leiden University Medical Center, 2333 ZC Leiden, the Netherlands.
Camilla SalvagnoDivision of Tumor Biology & Immunology, Oncode Institute, the Netherlands Cancer Institute, 1066 CX Amsterdam, the Netherlands.
Theodore S KapellosGenomics and Immunoregulation, LIMES Institute, University of Bonn, 53113 Bonn, Germany.
Cheei-Sing HauDivision of Tumor Biology & Immunology, Oncode Institute, the Netherlands Cancer Institute, 1066 CX Amsterdam, the Netherlands.
Lea SeepGenomics and Immunoregulation, LIMES Institute, University of Bonn, 53113 Bonn, Germany.
Marie OestreichGenomics and Immunoregulation, LIMES Institute, University of Bonn, 53113 Bonn, Germany.
Kathrin KleeGenomics and Immunoregulation, LIMES Institute, University of Bonn, 53113 Bonn, Germany.
Karin E de VisserDivision of Tumor Biology & Immunology, Oncode Institute, the Netherlands Cancer Institute, 1066 CX Amsterdam, the Netherlands. Electronic address: k.d.visser@nki.nl.
Thomas UlasGenomics and Immunoregulation, LIMES Institute, University of Bonn, 53113 Bonn, Germany.
Joachim L SchultzeGenomics and Immunoregulation, LIMES Institute, University of Bonn, 53113 Bonn, Germany; Platform for Single Cell Genomics and Epigenomics (PRECISE) at the German Center for Neurodegenerative Diseases and the University of Bonn, 53127 Bonn, Germany. Electronic address: j.schultze@uni-bonn.de.
University of Bonn · DEThe Netherlands Cancer Institute · NLLeiden University Medical Center · NL

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Tumor-associated macrophages (TAMs) are frequently the most abundant immune cells in cancers and are associated with poor survival. Here, we generated TAM molecular signatures from K14cre;Cdh1

Indexed as

Gene Expression ProfilingTranscription, GeneticAnimalsBreast NeoplasmsCarcinogenesisDisease Models, AnimalFemaleGene Expression Regulation, NeoplasticHumansMacrophagesMammary Neoplasms, AnimalMice, Inbred BALB CMice, TransgenicPhenotypePrognosisRNA, MessengerRNA, Messengerbreast cancerclinical outcome predictionco-expression network analysishumaninnate immunityinvasive lobular carcinomamouse modeltranscriptometumor-associated macrophage

Identifiers

PMID31665635
PMCPMC7057267
OpenAlexW2982295343

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.