Evidence map›Paper›PMID 31665544›Full record

ArticleMedical physics2020

Cherenkov imaging for total skin electron therapy (TSET).

Yunhe Xie, Heather Petroccia, Amit Maity, Tianshun Miao, Yihua Zhu, Petr Bruza, Brian W Pogue, John P Plastaras, Lei Dong, Timothy C Zhu

Abstract read
In one paragraph

Article in Medical physics, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.

0numbers the graph read from it
0cells of the map it votes in
22citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

22 citing papers in PubMed.

  1. Assessment of Linac photon dose delivery on Cherenkov production.Physics and imaging in radiation oncology · 2026
    Article
  2. Article
  3. Article
  4. Article
  5. Stereo Cherenkov imaging as 3D absolute dose monitoring tool for total skin electron therapy (TSET).Proceedings of SPIE--the International Society for Optical Engineering · 2026
    Article
  6. Hybrid Monte Carlo model for efficient tissue Cherenkov emission estimation to assess changes from beam size, energy and incidence.Physica medica : PM : an international journal devoted to the applications of physics to medicine and biology : official journal of the Italian Association of Biomedical Physics (AIFB) · 2025
    Article
  7. Review
  8. Assessment of generic corrections for multiview Cherenkov emission during total skin electron therapy (TSET).Proceedings of SPIE--the International Society for Optical Engineering · 2025
    Article
  9. Real-time dosimetry using scintillator technology in external beam radiation therapy (EBRT).Proceedings of SPIE--the International Society for Optical Engineering · 2025
    Article
  10. Total Skin Treatment with Helical Arc Radiotherapy.International journal of molecular sciences · 2023
    Review
  11. Article
  12. Article
  13. Article
  14. Monte Carlo (MC) study of dose distribution and Cherenkov imaging in total skin electron therapy (TSET) with TOPAS.Proceedings of SPIE--the International Society for Optical Engineering · 2021
    Article
  15. Cherenkov imaging for Total Skin Electron Therapy - an evaluation of dose uniformity.Proceedings of SPIE--the International Society for Optical Engineering · 2021
    Article
  16. Article
  17. Article
  18. Article
  19. Article
  20. Evaluation of the cumulative Cherenkov converted dose on TSET patients with multiple Cherenkov cameras.Proceedings of SPIE--the International Society for Optical Engineering
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Yunhe XieDepartment of Radiation Oncology, University of Pennsylvania, Philadelphia, PA, 19104, USA.
Heather PetrocciaDepartment of Radiation Oncology, University of Pennsylvania, Philadelphia, PA, 19104, USA.
Amit MaityDepartment of Radiation Oncology, University of Pennsylvania, Philadelphia, PA, 19104, USA.
Tianshun MiaoThayer School of Engineering, Dartmouth College, Hanover, NH, 03755, USA.
Yihua ZhuDepartment of Radiation Oncology, University of Pennsylvania, Philadelphia, PA, 19104, USA.
Petr BruzaThayer School of Engineering, Dartmouth College, Hanover, NH, 03755, USA.
Brian W PogueThayer School of Engineering, Dartmouth College, Hanover, NH, 03755, USA.
John P PlastarasDepartment of Radiation Oncology, University of Pennsylvania, Philadelphia, PA, 19104, USA.
Lei DongDepartment of Radiation Oncology, University of Pennsylvania, Philadelphia, PA, 19104, USA.
Timothy C ZhuDepartment of Radiation Oncology, University of Pennsylvania, Philadelphia, PA, 19104, USA.

Funding

Cherenkov imaging of Total Skin Electron Therapy (TSET)R21CA239127 · NCI · UNIVERSITY OF PENNSYLVANIA · PI ZHU, TIMOTHY C. · 2020 to 2021
$386k
NCI NIH HHS R21 CA239127
6 · The paper itself

Abstract

backgroundTotal skin electron therapy (TSET) utilizes high-energy electrons to treat malignancies on the entire body surface. The otherwise invisible radiation beam can be observed via the optical Cherenkov photons emitted from interactions between the high-energy electron beam and tissue. METHODS AND MATERIALS: With a time-gated intensified camera system, the Cherenkov emission can be used to evaluate the dose uniformity on the surface of the patient in real time. Fifteen patients undergoing TSET in various conditions (whole body and half body) were imaged and analyzed. Each patient was monitored during TSET via in vivo detectors (IVD) in nine locations. For accurate Cherenkov imaging, a comparison between IVD and Cherenkov profiles was conducted using a polyvinyl chloride board to establish the perspective corrections. RESULTS AND DISCUSSION: With proper corrections developed in this study including the perspective and inverse square corrections, the Cherenkov imaging provided two-dimensional maps proportional to dose and projected on patient skin. The results of ratio between chest and umbilicus points were in good agreement with in vivo point dose measurements, with a standard deviation of 2.4% compared to OSLD measurements.

conclusionsCherenkov imaging is a viable tool for validating patient-specific dose distributions during TSET.

Indexed as

Optical ImagingAdultAgedAged, 80 and overElectronsFemaleHumansMaleMiddle AgedRadiotherapy DosageSkin Neoplasmsbiomedical opticscherenkov imagingradiation therapytotal skin electron therapy

Identifiers

PMID31665544
PMCPMC7050296

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.