ArticleNucleic acids research2020
BacFITBase: a database to assess the relevance of bacterial genes during host infection.
Article in Nucleic acids research, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
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Who cites it
9 citing papers in PubMed, 15 citations in OpenAlex.
- Time-resolved dual transcriptomics ofBiofilm · 2025Article
- Towards interoperability in infection control: a standard data model for microbiology.Scientific data · 2023Article
- HPIPred: Host-pathogen interactome prediction with phenotypic scoring.Computational and structural biotechnology journal · 2022Article
- Bile Salts Regulate Zinc Uptake and Capsule Synthesis in a Mastitis-Associated Extraintestinal Pathogenic Escherichia coli Strain.Infection and immunity · 2021Article
- Time-Resolved Transcriptional Profiling of Epithelial Cells Infected by IntracellularMicroorganisms · 2021Article
- Pangenome Analytics Reveal Two-Component Systems as Conserved Targets in ESKAPEE Pathogens.mSystems · 2021Article
- DualSeqDB: the host-pathogen dual RNA sequencing database for infection processes.Nucleic acids research · 2021Article
- Bacteria use structural imperfect mimicry to hijack the host interactome.PLoS computational biology · 2020Article
- A global data-driven census ofmicroLife · 2020Article
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Authors and funding
4 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Bacterial infections have been on the rise world-wide in recent years and have a considerable impact on human well-being in terms of attributable deaths and disability-adjusted life years. Yet many mechanisms underlying bacterial pathogenesis are still poorly understood. Here, we introduce the BacFITBase database for the systematic characterization of bacterial proteins relevant for host infection aimed to enable the identification of new antibiotic targets. BacFITBase is manually curated and contains more than 90 000 entries with information on the contribution of individual genes to bacterial fitness under in vivo infection conditions in a range of host species. The data were collected from 15 different studies in which transposon mutagenesis was performed, including top-priority pathogens such as Acinetobacter baumannii and Campylobacter jejuni, for both of which increasing antibiotic resistance has been reported. Overall, BacFITBase includes information on 15 pathogenic bacteria and 5 host vertebrates across 10 different tissues. It is freely available at www.tartaglialab.com/bacfitbase.
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