Evidence map›Paper›PMID 31665441›Full record

ArticleNucleic acids research2020

CARD 2020: antibiotic resistome surveillance with the comprehensive antibiotic resistance database.

Brian P Alcock, Amogelang R Raphenya, Tammy T Y Lau, Kara K Tsang, Mégane Bouchard, Arman Edalatmand, William Huynh, Anna-Lisa V Nguyen, Annie A Cheng, Sihan Liu and 24 more

Registry-linked trialAbstract read
In one paragraph

Article in Nucleic acids research, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06566898 (Monitoring of Antimicrobial Resistance Based on Metagenomics Analyses in Pneumonia Patients), which is not on this map. Cited by 2,107 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
2,107citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT06566898 recruitingnot on this mapstarted 2024, after this paper: background citation

Monitoring of Antimicrobial Resistance Based on Metagenomics Analyses in Pneumonia Patients: a Genomic Epidemiology Study

TypeobservationalSponsorShanghai General Hospital, ChinaRan2024 to 2026Enrolled800ConditionsPneumonia, Next-generation Sequencing, Microbiome, Antimicrobial Resistance
3 · Its place in the literature

Who cites it

2,107 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
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  6. Draft genome sequence ofMicrobiology resource announcements · 2026
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  13. Microbiological safety and antimicrobial resistance in cashew-based plant-based cheese analogues.Brazilian journal of microbiology : [publication of the Brazilian Society for Microbiology] · 2026
    Article
  14. A functionally selectedApplied and environmental microbiology · 2026
    Article
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  17. ISmLife · 2026
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  18. Review
  19. Draft genome sequence ofMicrobiology resource announcements · 2026
    Article
  20. Genome sequences of sixMicrobiology resource announcements · 2026
    Article

2,047 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

34 authors.

Brian P AlcockDavid Braley Centre for Antibiotic Discovery, McMaster University, Hamilton, Ontario, L8S 4K1, Canada.
Amogelang R RaphenyaDavid Braley Centre for Antibiotic Discovery, McMaster University, Hamilton, Ontario, L8S 4K1, Canada.
Tammy T Y LauM.G. DeGroote Institute for Infectious Disease Research, McMaster University, Hamilton, Ontario, L8S 4K1, Canada.
Kara K TsangDavid Braley Centre for Antibiotic Discovery, McMaster University, Hamilton, Ontario, L8S 4K1, Canada.
Mégane BouchardM.G. DeGroote Institute for Infectious Disease Research, McMaster University, Hamilton, Ontario, L8S 4K1, Canada.
Arman EdalatmandM.G. DeGroote Institute for Infectious Disease Research, McMaster University, Hamilton, Ontario, L8S 4K1, Canada.
William HuynhM.G. DeGroote Institute for Infectious Disease Research, McMaster University, Hamilton, Ontario, L8S 4K1, Canada.
Anna-Lisa V NguyenM.G. DeGroote Institute for Infectious Disease Research, McMaster University, Hamilton, Ontario, L8S 4K1, Canada.
Annie A ChengM.G. DeGroote Institute for Infectious Disease Research, McMaster University, Hamilton, Ontario, L8S 4K1, Canada.
Sihan LiuM.G. DeGroote Institute for Infectious Disease Research, McMaster University, Hamilton, Ontario, L8S 4K1, Canada.
Sally Y MinM.G. DeGroote Institute for Infectious Disease Research, McMaster University, Hamilton, Ontario, L8S 4K1, Canada.
Anatoly MiroshnichenkoM.G. DeGroote Institute for Infectious Disease Research, McMaster University, Hamilton, Ontario, L8S 4K1, Canada.
Hiu-Ki TranM.G. DeGroote Institute for Infectious Disease Research, McMaster University, Hamilton, Ontario, L8S 4K1, Canada.
Rafik E WerfalliM.G. DeGroote Institute for Infectious Disease Research, McMaster University, Hamilton, Ontario, L8S 4K1, Canada.
Jalees A NasirM.G. DeGroote Institute for Infectious Disease Research, McMaster University, Hamilton, Ontario, L8S 4K1, Canada.
Martins OloniM.G. DeGroote Institute for Infectious Disease Research, McMaster University, Hamilton, Ontario, L8S 4K1, Canada.
David J SpeicherM.G. DeGroote Institute for Infectious Disease Research, McMaster University, Hamilton, Ontario, L8S 4K1, Canada.
Alexandra FlorescuM.G. DeGroote Institute for Infectious Disease Research, McMaster University, Hamilton, Ontario, L8S 4K1, Canada.
Bhavya SinghHonours Biology Program, McMaster University, Hamilton, Ontario, L8S 4K1, Canada.
Mateusz FaltynM.G. DeGroote Institute for Infectious Disease Research, McMaster University, Hamilton, Ontario, L8S 4K1, Canada.
Anastasia Hernandez-KoutouchevaCenter for Genome Sciences, National Autonomous University of Mexico, Cuernavaca, Morelos 62210, Mexico.
Arjun N SharmaM.G. DeGroote Institute for Infectious Disease Research, McMaster University, Hamilton, Ontario, L8S 4K1, Canada.
Emily BordeleauDavid Braley Centre for Antibiotic Discovery, McMaster University, Hamilton, Ontario, L8S 4K1, Canada.
Andrew C PawlowskiDepartment of Genetics, Harvard Medical School, Harvard University, Boston, MA 02115, USA.
Haley L ZubykDavid Braley Centre for Antibiotic Discovery, McMaster University, Hamilton, Ontario, L8S 4K1, Canada.
Damion DooleyDepartment of Pathology and Laboratory Medicine, University of British Columbia, Vancouver, V6T 2B5, British Columbia, Canada.
Emma GriffithsDepartment of Molecular Biology and Biochemistry, Simon Fraser University, Burnaby, British Columbia, V5A 1S6, Canada.
Finlay MaguireFaculty of Computer Science, Dalhousie University, Halifax, Nova Scotia, B3H 1W5, Canada.
Geoff L WinsorDepartment of Molecular Biology and Biochemistry, Simon Fraser University, Burnaby, British Columbia, V5A 1S6, Canada.
Robert G BeikoFaculty of Computer Science, Dalhousie University, Halifax, Nova Scotia, B3H 1W5, Canada.
Fiona S L BrinkmanDepartment of Molecular Biology and Biochemistry, Simon Fraser University, Burnaby, British Columbia, V5A 1S6, Canada.
William W L HsiaoDepartment of Pathology and Laboratory Medicine, University of British Columbia, Vancouver, V6T 2B5, British Columbia, Canada.
Gary V DomselaarNational Microbiology Laboratory, Public Health Agency of Canada, Winnipeg, Manitoba, R3E 3R2, Canada.
Andrew G McArthurDavid Braley Centre for Antibiotic Discovery, McMaster University, Hamilton, Ontario, L8S 4K1, Canada.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The Comprehensive Antibiotic Resistance Database (CARD; https://card.mcmaster.ca) is a curated resource providing reference DNA and protein sequences, detection models and bioinformatics tools on the molecular basis of bacterial antimicrobial resistance (AMR). CARD focuses on providing high-quality reference data and molecular sequences within a controlled vocabulary, the Antibiotic Resistance Ontology (ARO), designed by the CARD biocuration team to integrate with software development efforts for resistome analysis and prediction, such as CARD's Resistance Gene Identifier (RGI) software. Since 2017, CARD has expanded through extensive curation of reference sequences, revision of the ontological structure, curation of over 500 new AMR detection models, development of a new classification paradigm and expansion of analytical tools. Most notably, a new Resistomes & Variants module provides analysis and statistical summary of in silico predicted resistance variants from 82 pathogens and over 100 000 genomes. By adding these resistance variants to CARD, we are able to summarize predicted resistance using the information included in CARD, identify trends in AMR mobility and determine previously undescribed and novel resistance variants. Here, we describe updates and recent expansions to CARD and its biocuration process, including new resources for community biocuration of AMR molecular reference data.

Indexed as

Databases, GeneticDrug Resistance, BacterialGenes, BacterialSoftwareBacteriaBacterial ProteinsBacterial Proteins

Identifiers

PMID31665441
PMCPMC7145624

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.