ArticleNeuro-oncology2020
Lack of association between modifiable exposures and glioma risk: a Mendelian randomization analysis.
Article in Neuro-oncology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers, 4 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
27 citing papers in PubMed, 4 syntheses or guidelines pooled it, 32 citations in OpenAlex.
- Vitamin D and human health: evidence from Mendelian randomization studies.European journal of epidemiology · 2024Pooled it
- Serum 25-Hydroxyvitamin D and Cancer Risk: A Systematic Review of Mendelian Randomization Studies.Nutrients · 2023Pooled it
- Systematic review of Mendelian randomization studies on risk of cancer.BMC medicine · 2022Pooled it
- Causal role of high body mass index in multiple chronic diseases: a systematic review and meta-analysis of Mendelian randomization studies.BMC medicine · 2021Pooled it
- Impact of postoperative blood pressure management on postoperative hemorrhage after resection of intraparenchymal brain tumors.Acta neurochirurgica · 2026Article
- TTF2 as a potential biomarker and immunotherapy target in glioma diagnosis and prognosis.Scientific reports · 2026Article
- Injectable microgels loaded with programmable WELNs based on mendelian randomization macroanalysis alleviate osteoarthritis by restoring the circadian rhythm.Bioactive materials · 2026Article
- Imaging-mediated genetic effects link brain microstructure, metabolic profiles, and regional transcription to glioma susceptibility.Frontiers in immunology · 2026Article
- Machine learning-based construction of Immunogenic cell death-related score for improving prognosis and personalized treatment in glioma.Scientific reports · 2025Article
- Glioma raises periodontitis risk via CD8 upregulation on NKT cells: a Mendelian randomization study.Discover oncology · 2025Article
- The role of postoperative blood pressure management in early postoperative hemorrhage in awake craniotomy glioma patients.Neurosurgical review · 2024Article
- The non-causative role of abnormal serum uric acid in intervertebral disc degeneration: A Mendelian randomization study.JOR spine · 2024Article
- Assessing causal association of circulating micronutrients and systemic lupus erythematosus susceptibility: a Mendelian randomization study.Frontiers in nutrition · 2024Article
- Relationships among gut microbiota, plasma metabolites, and juvenile idiopathic arthritis: a mediation Mendelian randomization study.Frontiers in microbiology · 2024Article
- TGIF2 is a potential biomarker for diagnosis and prognosis of glioma.Frontiers in immunology · 2024Article
- Aminopeptidase O Protein mediates the association betweenFrontiers in microbiology · 2024Article
- Association between viral infections and glioma risk: a two-sample bidirectional Mendelian randomization analysis.BMC medicine · 2023Article
- Causal effects of potential risk factors on postpartum depression: a Mendelian randomization study.Frontiers in psychiatry · 2023Article
- Prediagnostic biomarkers for early detection of glioma-using case-control studies from cohorts as study approach.Neuro-oncology advances · 2022Article
- A combined healthy lifestyle score in relation to glioma: a case-control study.Nutrition journal · 2022Article
Corrections and comments
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Authors and funding
20 authors at 13 institutions in 5 countries.
Funding
Abstract
backgroundThe etiological basis of glioma is poorly understood. We have used genetic markers in a Mendelian randomization (MR) framework to examine if lifestyle, cardiometabolic, and inflammatory factors influence the risk of glioma. This methodology reduces bias from confounding and is not affected by reverse causation.
methodsWe identified genetic instruments for 37 potentially modifiable risk factors and evaluated their association with glioma risk using data from a genome-wide association study of 12 488 glioma patients and 18 169 controls. We used the estimated odds ratio of glioma associated with each of the genetically defined traits to infer evidence for a causal relationship with the following exposures:Lifestyle and dietary factors-height, plasma insulin-like growth factor 1, blood carnitine, blood methionine, blood selenium, blood zinc, circulating adiponectin, circulating carotenoids, iron status, serum calcium, vitamins (A1, B12, B6, E, and 25-hydroxyvitamin D), fatty acid levels (monounsaturated, omega-3, and omega-6) and circulating fetuin-A;Cardiometabolic factors-birth weight, high density lipoprotein cholesterol, low density lipoprotein cholesterol, total cholesterol, total triglycerides, basal metabolic rate, body fat percentage, body mass index, fasting glucose, fasting proinsulin, glycated hemoglobin levels, diastolic and systolic blood pressure, waist circumference, waist-to-hip ratio; andInflammatory factors- C-reactive protein, plasma interleukin-6 receptor subunit alpha and serum immunoglobulin E.
resultsAfter correction for the testing of multiple potential risk factors and excluding associations driven by one single nucleotide polymorphism, no significant association with glioma risk was observed (ie, PCorrected > 0.05).
conclusionsThis study did not provide evidence supporting any of the 37 factors examined as having a significant influence on glioma risk.
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Registered trials
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