ArticleThe Journal of antimicrobial chemotherapy2020
Persistent circulation of a fluoroquinolone-resistant Salmonella enterica Typhi clone in the Indian subcontinent.
Article in The Journal of antimicrobial chemotherapy, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers, 2 of them syntheses that pooled it.
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Who cites it
22 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Geographic and genomic determinants of antimicrobial resistance in indian children: a systematic review and meta-analysis.BMC pediatrics · 2026Pooled it
- Pooled it
- A contemporary genomic snapshot ofMicrobial genomics · 2025Article
- The molecular mechanisms of quinolone resistance in Salmonella: a review.Archives of microbiology · 2025Review
- The origins of haplotype 58 (H58) Salmonella enterica serovar Typhi.Communications biology · 2024Article
- Novel Fluoroquinolones with Possible Antibacterial Activity in Gram-Negative Resistant Pathogens: In Silico Drug Discovery.Molecules (Basel, Switzerland) · 2023Article
- Article
- A Ten-Year Retrospective Survey of Antimicrobial Susceptibility Patterns among Salmonella enterica subsp.Microbiology spectrum · 2023Article
- Paratype: a genotyping tool for Salmonella Paratyphi A reveals its global genomic diversity.Nature communications · 2022Article
- Article
- Hotspots sequences of gyrA, gyrB, parC, and parE genes encoded for fluoroquinolones resistance from local Salmonella Typhi strains in Jakarta.BMC microbiology · 2022Article
- The international and intercontinental spread and expansion of antimicrobial-resistant Salmonella Typhi: a genomic epidemiology study.The Lancet. Microbe · 2022Article
- Circulation of Third-Generation Cephalosporin Resistant Salmonella Typhi in Mumbai, India.Clinical infectious diseases : an official publication of the Infectious Diseases Society of America · 2022Article
- Whole genome sequence analysis of Salmonella Typhi in Papua New Guinea reveals an established population of genotype 2.1.7 sensitive to antimicrobials.PLoS neglected tropical diseases · 2022Review
- Antimicrobial resistance among GLASS priority pathogens from Pakistan: 2006-2018.BMC infectious diseases · 2021Article
- Genomic Epidemiology and Antimicrobial Resistance Mechanisms of Imported Typhoid in Australia.Antimicrobial agents and chemotherapy · 2021Article
- A genomic data resource for predicting antimicrobial resistance from laboratory-derived antimicrobial susceptibility phenotypes.Briefings in bioinformatics · 2021Article
- Article
- A global resource for genomic predictions of antimicrobial resistance and surveillance of Salmonella Typhi at pathogenwatch.Nature communications · 2021Article
- Article
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9 authors.
Funding
Abstract
backgroundThe molecular structure of circulating enteric fever pathogens was studied using hospital-based genomic surveillance in a tertiary care referral centre in South India as a first genomic surveillance study, to our knowledge, of blood culture-confirmed enteric fever in the region.
methodsBlood culture surveillance was conducted at St John's Medical College Hospital, Bengaluru, between July 2016 and June 2017. The bacterial isolates collected were linked to demographic variables of patients and subjected to WGS. The resulting pathogen genomic data were also globally contextualized to gauge possible phylogeographical patterns.
resultsHospital-based genomic surveillance for enteric fever in Bengaluru, India, identified 101 Salmonella enterica Typhi and 14 S. Paratyphi A in a 1 year period. Ninety-six percent of isolates displayed non-susceptibility to fluoroquinolones. WGS showed the dominant pathogen was S. Typhi genotype 4.3.1.2 (H58 lineage II). A fluoroquinolone-resistant triple-mutant clone of S. Typhi 4.3.1.2 previously associated with gatifloxacin treatment failure in Nepal was implicated in 18% of enteric fever cases, indicating ongoing inter-regional circulation.
conclusionsEnteric fever in South India continues to be a major public health issue and is strongly associated with antimicrobial resistance. Robust microbiological surveillance is necessary to direct appropriate treatment and preventive strategies. Of particular concern is the emergence and expansion of the highly fluoroquinolone-resistant triple-mutant S. Typhi clone and its ongoing inter- and intra-country transmission in South Asia, which highlights the need for regional coordination of intervention strategies, including vaccination and longer-term strategies such as improvements to support hygiene and sanitation.
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