ArticleCerebral cortex (New York, N.Y. : 1991)2020
Maternal Interleukin-6 Is Associated With Macaque Offspring Amygdala Development and Behavior.
Article in Cerebral cortex (New York, N.Y. : 1991), 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
18 citing papers in PubMed, 27 citations in OpenAlex.
- Associations between chronic placental inflammation, fetal brain development and later autism traits.Brain, behavior, & immunity - health · 2026Article
- Sex-related difference of subcortical gray matter volume associated with crystallized intelligence in young adults with obesity.Biology of sex differences · 2026Article
- Perinatal Western-style diet exposure associated with altered sensory functional connectivity in infant Japanese macaques.Physiological reports · 2025Article
- Adipokines measured during pregnancy and at birth are associated with infant negative affect.Brain, behavior, and immunity · 2024Article
- Segmenting hypothalamic subunits in human newborn magnetic resonance imaging data.Human brain mapping · 2024Article
- Early-in-life isoflurane exposure alters resting-state functional connectivity in juvenile non-human primates.British journal of anaesthesia · 2023Article
- Depression, anxiety, insomnia and interleukins in the early postpartum period.Frontiers in psychiatry · 2023Article
- Comorbidity of Anxiety and Hypertension: Common Risk Factors and Potential Mechanisms.International journal of hypertension · 2023Review
- Impact of Maternal Immune Activation on Nonhuman Primate Prefrontal Cortex Development: Insights for Schizophrenia.Biological psychiatry · 2022Review
- Carotenoids improve the development of cerebral cortical networks in formula-fed infant macaques.Scientific reports · 2022Article
- Effect of advanced parental age on pregnancy outcome and offspring health.Journal of assisted reproduction and genetics · 2022Review
- Maternal diet and obesity shape offspring central and peripheral inflammatory outcomes in juvenile non-human primates.Brain, behavior, and immunity · 2022Article
- Pubertal timing and functional neurodevelopmental alterations independently mediate the effect of family conflict on adolescent psychopathology.Developmental cognitive neuroscience · 2021Article
- Maternal Immune Activation during Pregnancy Alters Postnatal Brain Growth and Cognitive Development in Nonhuman Primate Offspring.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2021Article
- Understanding Vulnerability and Adaptation in Early Brain Development using Network Neuroscience.Trends in neurosciences · 2021Review
- Canonical TGF-β signaling regulates the relationship between prenatal maternal depression and amygdala development in early life.Translational psychiatry · 2021Article
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Corrections and comments
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Authors and funding
18 authors at 3 institutions in 1 country.
Funding
Abstract
Human and animal cross-sectional studies have shown that maternal levels of the inflammatory cytokine interleukin-6 (IL-6) may compromise brain phenotypes assessed at single time points. However, how maternal IL-6 associates with the trajectory of brain development remains unclear. We investigated whether maternal IL-6 levels during pregnancy relate to offspring amygdala volume development and anxiety-like behavior in Japanese macaques. Magnetic resonance imaging (MRI) was administered to 39 Japanese macaque offspring (Female: 18), providing at least one or more time points at 4, 11, 21, and 36 months of age with a behavioral assessment at 11 months of age. Increased maternal third trimester plasma IL-6 levels were associated with offspring's smaller left amygdala volume at 4 months, but with more rapid amygdala growth from 4 to 36 months. Maternal IL-6 predicted offspring anxiety-like behavior at 11 months, which was mediated by reduced amygdala volumes in the model's intercept (i.e., 4 months). The results increase our understanding of the role of maternal inflammation in the development of neurobehavioral disorders by detailing the associations of a commonly examined inflammatory indicator, IL-6, on amygdala volume growth over time, and anxiety-like behavior.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.