ArticleThe journals of gerontology. Series A, Biological sciences and medical sciences2020
Uncontrolled Diabetes as an Associated Factor with Dynapenia in Adults Aged 50 Years or Older: Sex Differences.
Article in The journals of gerontology. Series A, Biological sciences and medical sciences, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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Who cites it
11 citing papers in PubMed.
- Braking Time and Cognitive, Visual, and Motor Determinants in Older Drivers With Type 2 Diabetes Mellitus With and Without Diabetic Peripheral Neuropathy: A Controlled Cross-Sectional Study.Journal of diabetes · 2026Article
- Can diabetic peripheral neuropathy influence the final outcome of physical performance after a combined training program in older adults? A double-blind quasi-experimental study.Physiological reports · 2026Article
- Glycated hemoglobin and dynapenia in community- dwelling older people with and without diabetes: A cross-sectional study.Journal of diabetes and metabolic disorders · 2026Article
- Can 12-Week Resistance Training Improve Muscle Strength, Dynamic Balance and the Metabolic Profile in Older Adults with Type 2 Diabetes Mellitus?International journal of environmental research and public health · 2025Article
- Could poor glycaemic control be a predictor of walking speed decline in older adults? Evidence from the English Longitudinal Study of Ageing.Diabetes, obesity & metabolism · 2024Article
- Dynapenia and sarcopenia: association with the diagnosis, duration and complication of type 2 diabetes mellitus in ELSA-Brasil.Cadernos de saude publica · 2024Article
- Do lifestyle, anthropometric and demographic factors associated with muscle strength differ in a UK and Japanese cohort? An exploratory analysis.Aging clinical and experimental research · 2023Article
- Does the incidence of frailty differ between men and women over time?Archives of gerontology and geriatrics · 2023Article
- Prevalence of dynapenia and overlap with disability, depression, and executive dysfunction.Revista de saude publica · 2023Article
- Predictive Models of Muscle Strength in Older People with Type 2 Diabetes Mellitus.Clinical interventions in aging · 2023Article
- Are Serum 25-Hydroxyvitamin D Deficiency and Insufficiency Risk Factors for the Incidence of Dynapenia?Calcified tissue international · 2022Article
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Authors and funding
4 authors.
Funding
Abstract
backgroundEpidemiological studies demonstrate an association between diabetes and low neuromuscular strength (NMS). However, none have grouped participants into nondiabetics (ND), undiagnosed diabetics (UDD), controlled diabetics (CD), and uncontrolled diabetics (UCD) or investigated what glycated hemoglobin levels (HbA1c) are associated with low NMS (dynapenia) by sex.
methodsWe analyzed the association between UDD, CD, and UCD and dynapenia, the extent to which the different groupings of these individuals modifies this association and the association between HbA1c levels and NMS, by sex, in a cross-sectional study involving 5,290 participants ≥50 years from the ELSA study. In the first two analyses, logistic regression models were used with dynapenia (grip strength <26 kg in men and <16 kg in women) as outcome and diabetes (ND, UDD, CD, and UCD) as exposure. Next, linear regression was performed with grip strength as the outcome, and the participants were classified based on HbA1c level as exposure. The models were adjusted by sociodemographic, behavioral, and clinical characteristics.
resultsCompared to ND, only UCD was associated with dynapenia (men OR = 2.37 95% CI 1.36-4.14; women OR = 1.67 95% CI 1.01-2.79). This association was less clear, particularly in women, when CD and UCD groups were merged. HbA1c ≥6.5% in men and ≥8.0% in women were associated with lower NMS.
conclusionsUCD increases the chance of dynapenia in both sexes. The different groupings based on diabetes status modify the association between UCD and dynapenia. The threshold of HbA1c associated with reduced NMS is lower in men compared to women.
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