Evidence map›Paper›PMID 31665069›Full record

ArticleActa neuropathologica communications2019

Fragile X-associated tremor ataxia syndrome with co-occurrent progressive supranuclear palsy-like neuropathology.

Amanda N Sacino, Stefan Prokop, Meggen A Walsh, Jennifer Adamson, S H Subramony, Amy Krans, Peter K Todd, Benoit I Giasson, Anthony T Yachnis

Open access · goldAbstract readCase Reports
PubMed Full text at PMC Publisher
In one paragraph

Article in Acta neuropathologica communications, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
1.3field-weighted citation impact, top 18% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 10 citations in OpenAlex.

  1. Neurodegeneration of White and Gray Matter in the Hippocampus with FXTAS.International journal of molecular sciences · 2023
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 3 institutions in 1 country.

Amanda N SacinoDepartment of Neuroscience, College of Medicine, University of Florida, Gainesville, FL, USA.
Stefan ProkopCenter for Translational Research in Neurodegenerative Disease, University of Florida, Gainesville, FL, USA. sprokop@ufl.edu.ORCID 0000-0002-5633-2149
Meggen A WalshDepartment of Pathology, College of Medicine, University of Florida, Gainesville, FL, USA.
Jennifer AdamsonCenter for Translational Research in Neurodegenerative Disease, University of Florida, Gainesville, FL, USA.
S H SubramonyDepartment of Neurology, College of Medicine, University of Florida, Gainesville, USA.
Amy KransVA Ann Arbor Healthcare Center, Ann Arbor, MI, USA.
Peter K ToddVA Ann Arbor Healthcare Center, Ann Arbor, MI, USA.
Benoit I GiassonDepartment of Neuroscience, College of Medicine, University of Florida, Gainesville, FL, USA.
Anthony T YachnisDepartment of Pathology, College of Medicine, University of Florida, Gainesville, FL, USA.
University of Florida · USUniversity of Michigan · USVA Ann Arbor Healthcare System · US

Funding

University of Florida - Mt. Sinai Medical Center AD Research CenterP50AG047266 · NIA · UNIVERSITY OF FLORIDA · PI LOEWENSTEIN, DAVID · 2015 to 2019
$7.3M
Hexanucleotide repeat translation in ALS and Frontotemporal DementiaR01NS099280 · NINDS · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI Peter K Todd · 2016 to 2026
$4.9M
CGG repeat associated translation in Fragile X-associated Tremor/Ataxia Syndrome-Diversity SupplementR01NS086810 · NINDS · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI TODD, PETER K · 2014 to 2024
$4.1M
NIA NIH HHS P50 AG047266NIA NIH HHS P50 AG047266-01A1NINDS NIH HHS R01 NS086810NINDS NIH HHS R01 NS099280
6 · The paper itself

Abstract

Co-occurrence of multiple neuropathologic changes is a common phenomenon, most prominently seen in Alzheimer's disease (AD) and Parkinson's disease (PD), complicating clinical diagnosis and patient management. Reports of co-occurring pathological processes are emerging in the group of genetically defined repeat-associated non-AUG (RAN)-translation related diseases. Here we report a case of Fragile X-associated tremor-ataxia syndrome (FXTAS) with widespread and abundant nuclear inclusions of the RAN-translation related FMRpolyG-peptide. In addition, we describe prominent neuronal and glial tau pathology representing changes seen in progressive supranuclear palsy (PSP). The highest abundance of the respective pathological changes was seen in distinct brain regions indicating an incidental, rather than causal correlation.

Indexed as

AgedAtaxiaBrainFragile X Messenger Ribonucleoprotein 1Fragile X SyndromeHumansIntranuclear Inclusion BodiesMaleNeurogliaNeuronsSupranuclear Palsy, ProgressiveTremorFMR1 protein, humanFragile X Messenger Ribonucleoprotein 1FXTASPSPRAN-translation

Identifiers

PMID31665069
PMCPMC6820960
OpenAlexW2982492211

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.