Evidence map›Paper›PMID 31665035›Full record

ArticleHealth and quality of life outcomes2019

Parent proxy assessment of sibling quality of life following pediatric hematopoietic cell transplantation.

David Buchbinder, Sunita K Patel, Jacqueline N Casillas, Diane J Nugent, Steven Neudorf, Leonard S Sender, Lilibeth Torno, Heather Huszti, Lonnie K Zeltzer, Susan K Parsons

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In one paragraph

Article in Health and quality of life outcomes, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Guideline
  2. Article
  3. Review
  4. Article
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

David BuchbinderDepartment of Pediatrics and Division of Pediatric Hematology, CHOC Children's Hospital and University of California at Irvine's Chao Family Comprehensive Cancer Center, Irvine, California, USA. dbuchbinder@choc.org.ORCID http://orcid.org/0000-0002-9470-3473
Sunita K PatelDepartment of Cancer Control and Population Sciences, City of Hope, Duarte, California, USA.
Jacqueline N CasillasDepartment of Pediatrics and Division of Pediatric Hematology and Oncology, David Geffen School of Medicine at University of California at Los Angeles and University of California at Los Angeles's Jonsson Comprehensive Cancer Center, Los Angeles, California, USA.
Diane J NugentDepartment of Pediatrics and Division of Hematology at CHOC Children's Hospital, Orange, California, USA.
Steven NeudorfDepartment of Pediatrics and Division of Oncology at CHOC Children's Hospital, Orange, California, USA.
Leonard S SenderDepartment of Pediatrics and Division of Oncology at CHOC Children's Hospital, Orange, California, USA.
Lilibeth TornoDepartment of Pediatrics and Division of Oncology at CHOC Children's Hospital, Orange, California, USA.
Heather HusztiDepartment of Pediatrics and Division of Psychology at CHOC Children's Hospital, Orange, California, USA.
Lonnie K ZeltzerPsychiatry / Biobehavioral Science, and Division of Cancer Prevention and Control Research, David Geffen School of Medicine at University of California at Los Angeles and University of California at Los Angeles's Jonsson Comprehensive Cancer Center, Los Angeles, California, USA.
Susan K ParsonsInstitute of Clinical Research and Health Policy Studies at Tufts Medical Center and Departments of Medicine and Pediatrics, at Tufts University School of Medicine, Boston, Massachusetts, USA.

Funding

American Society of Clinical Oncology Career Development AwardPSF Tithe Grant
6 · The paper itself

Abstract

backgroundWhen a child undergoes hematopoietic cell transplantation (HCT), the impact extends to the entire family, including siblings. Assessment of the quality of life (QoL) of siblings is challenged by their general lack of availability for regular assessment by clinical providers. Thus, the use of parent proxy reporting may be useful. Our aim was to describe the QoL of siblings of HCT survivors, as reported by their parents, as well as to identify parent and family factors associated with lower sibling QoL.

methodsA cross-sectional study was utilized to assess parent-reported QoL of the HCT recipient's sibling (Short Form (SF)-10 Health Survey for Children and the Pediatric Symptom Checklist (PSC)-17). Parent QoL was assessed using the SF-12. Multivariable linear regression was used to explore hypothesized predictors of sibling QoL, including parent QoL, family impact/function (Impact on Family Scale, Family Adaptability and Cohesion Evaluation Scales, IV, and a question asking about financial problems) while adjusting for demographic and HCT characteristics.

resultsNinety-seven siblings (55% males) with a mean age of 12 years (standard deviation [SD] 4 years) were assessed, representing HCT survivors, who were an average of 5 years (SD 4 years) post-HCT. Neither sibling psychosocial (mean 49.84, SD 10.70, p = 0.87) nor physical health scores (mean 51.54, SD 8.42, p = 0.08) differed from norms. Parent proxies reported behavioral/emotional problems (PSC-17 total score > 15) in 24% of siblings. While parental ratings of their own physical health (SF-12 were higher than norms (mean 53.04, SD 8.17, p = 0.0005), mental health scores were lower (mean 45.48, SD 10.45, p < 0.0001). In multivariable analysis, lower parent emotional functioning and adverse family function were associated with lower sibling QoL, as reported by parents.

conclusionsWhile proxy-reported QoL of siblings did not differ significantly from normative data, both parent QoL and family function were associated with sibling QoL. Future research is needed to understand how siblings themselves perceive their QoL following HCT.

Indexed as

AdolescentAdultChildChild, PreschoolCross-Sectional StudiesFamily RelationsFemaleHematopoietic Stem Cell TransplantationHumansMaleMental DisordersMiddle AgedParentsQuality of LifeSiblingsSurveys and QuestionnairesFamilyHematopoietic stem cell transplantationQuality of lifeSibling

Identifiers

PMID31665035
PMCPMC6819636

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LicenceCC BY
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.