Evidence map›Paper›PMID 31665028›Full record

ArticleParticle and fibre toxicology2019

Safer-by-design flame-sprayed silicon dioxide nanoparticles: the role of silanol content on ROS generation, surface activity and cytotoxicity.

Laura Rubio, Georgios Pyrgiotakis, Juan Beltran-Huarac, Yipei Zhang, Joshi Gaurav, Glen Deloid, Anastasia Spyrogianni, Kristopher A Sarosiek, Dhimiter Bello, Philip Demokritou

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Particle and fibre toxicology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers.

0numbers the graph read from it
0cells of the map it votes in
30citing papers in PubMed
4.0field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

30 citing papers in PubMed, 75 citations in OpenAlex.

  1. Article
  2. Article
  3. Antioxidant Activity of SiOLangmuir : the ACS journal of surfaces and colloids · 2025
    Article
  4. Article
  5. SiOScientific reports · 2025
    Article
  6. Article
  7. Silicosis: from pathogenesis to therapeutics.Frontiers in pharmacology · 2025
    Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 3 institutions in 2 countries.

Laura RubioCenter for Nanotechnology and Nanotoxicology, HSPH-NIEHS Nanosafety Center, Department of Environmental Health, Harvard T. H. Chan School of Public School, Harvard University, 665 Huntington, Boston, MA, 02115, USA.
Georgios PyrgiotakisCenter for Nanotechnology and Nanotoxicology, HSPH-NIEHS Nanosafety Center, Department of Environmental Health, Harvard T. H. Chan School of Public School, Harvard University, 665 Huntington, Boston, MA, 02115, USA.
Juan Beltran-HuaracCenter for Nanotechnology and Nanotoxicology, HSPH-NIEHS Nanosafety Center, Department of Environmental Health, Harvard T. H. Chan School of Public School, Harvard University, 665 Huntington, Boston, MA, 02115, USA.
Yipei ZhangDepartment of Biomedical and Nutritional Sciences, Zuckerberg College of Health Sciences, University of Massachusetts Lowell, Lowell, MA, 01854, USA.
Joshi GauravJohn B. Little Center for Radiation Sciences, Department of Environmental Health, Harvard T.H. Chan School of Public Health, Boston, MA, 02115, USA.
Glen DeloidCenter for Nanotechnology and Nanotoxicology, HSPH-NIEHS Nanosafety Center, Department of Environmental Health, Harvard T. H. Chan School of Public School, Harvard University, 665 Huntington, Boston, MA, 02115, USA.
Anastasia SpyrogianniParticle Technology Laboratory, Institute of Process Engineering, Department of Mechanical and Process Engineering, ETH Zurich, Sonneggstrasse 3, CH-8092, Zurich, Switzerland.
Kristopher A SarosiekJohn B. Little Center for Radiation Sciences, Department of Environmental Health, Harvard T.H. Chan School of Public Health, Boston, MA, 02115, USA.
Dhimiter BelloDepartment of Biomedical and Nutritional Sciences, Zuckerberg College of Health Sciences, University of Massachusetts Lowell, Lowell, MA, 01854, USA.
Philip DemokritouCenter for Nanotechnology and Nanotoxicology, HSPH-NIEHS Nanosafety Center, Department of Environmental Health, Harvard T. H. Chan School of Public School, Harvard University, 665 Huntington, Boston, MA, 02115, USA. pdemokri@hsph.harvard.edu.
Harvard University · USUniversity of Massachusetts Lowell · USETH Zurich · CH

Funding

Translational Research Support CoreP30ES000002 · NIEHS · HARVARD UNIVERSITY (SCH OF PUBLIC HLTH) · PI JAIME ELIZABETH HART · 1985 to 2026
$44.6M
Engineered Nanomaterial Synthesis, Characterization and Method Development Center for Nano-safety ResearchU24ES026946 · NIEHS · HARVARD SCHOOL OF PUBLIC HEALTH · PI DEMOKRITOU, PHILIP · 2016 to 2020
$3.8M
NIEHS NIH HHS P30 ES000002NIEHS NIH HHS U24 ES026946NIH HHS U24ES026946
6 · The paper itself

Abstract

backgroundAmorphous silica nanoparticles (SiO2 NPs) have been regarded as relatively benign nanomaterials, however, this widely held opinion has been questioned in recent years by several reports on in vitro and in vivo toxicity. Surface chemistry, more specifically the surface silanol content, has been identified as an important toxicity modulator for SiO2 NPs. Here, quantitative relationships between the silanol content on SiO

resultsConsistent and statistically significant trends were seen between the total silanol content, cell membrane damage, and cell viability, but not with intracellular reactive oxygen species (ROS), in the macrophages RAW264.7. SiO

conclusionSurface silanol content plays an important role in cellular toxicity and surface reactivity, although it might not be the sole factor influencing fumed silica NP toxicity. It was demonstrated that synthesis conditions for SiO

Indexed as

AnimalsCell Culture TechniquesCell MembraneCell SurvivalDose-Response Relationship, DrugMacrophagesMiceNanoparticlesOxidative StressRAW 264.7 CellsReactive Oxygen SpeciesSilanesSilicon DioxideSurface PropertiesReactive Oxygen SpeciesSilanessilanolSilicon DioxideAmorphous silicaFlame spray pyrolysisSilanol groupsSurface reactivityToxicity

Identifiers

PMID31665028
PMCPMC6819463
OpenAlexW2982379185

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.