Evidence map›Paper›PMID 31665023›Full record

ArticleEnvironmental health : a global access science source2019

Does the oxidative stress play a role in the associations between outdoor air pollution and persistent asthma in adults? Findings from the EGEA study.

Anaïs Havet, Zhen Li, Farid Zerimech, Margaux Sanchez, Valérie Siroux, Nicole Le Moual, Bert Brunekreef, Nino Künzli, Bénédicte Jacquemin, Raphaëlle Varraso and 2 more

Open access · goldAbstract read
In one paragraph

Article in Environmental health : a global access science source, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
1.5field-weighted citation impact, top 20% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 24 citations in OpenAlex.

  1. Trial
  2. Review
  3. Review
  4. Article
  5. Active Aging and Smart Public Parks.Geriatrics (Basel, Switzerland) · 2023
    Review
  6. Review
  7. Review
  8. Article
  9. External Environmental Pollution as a Risk Factor for Asthma.Clinical reviews in allergy & immunology · 2022
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 8 institutions in 5 countries.

Anaïs HavetINSERM U1168, VIMA: Aging and chronic diseases. Epidemiological and public health approaches, Villejuif, France. anais.havet@gmail.com.ORCID 0000-0002-5474-2064
Zhen LiKey Laboratory of Obstetric & Gynecologic and Pediatric Diseases and Birth Defects, Ministry of Education, West China Second University Hospital, Sichuan University, Chengdu, China.
Farid ZerimechCHU de Lille, Laboratoire de Biochimie et Biologie Moléculaire, Pôle de Biologie Pathologie Génétique, Lille, France.
Margaux SanchezISGlobal, Centre for Research in Environmental Epidemiology, Universitat Pompeu Fabra, CIBER Epidemiología y Salud Pública, Barcelona, Spain.
Valérie SirouxInstitute for Advanced Biosciences, Centre de recherche UGA-Inserm U1209 CNRS UMR 5309, équipe d'épidémiologie environnementale, Site Santé, Allée des Alpes, Grenoble, France.
Nicole Le MoualINSERM U1168, VIMA: Aging and chronic diseases. Epidemiological and public health approaches, Villejuif, France.
Bert BrunekreefInstitute for Risk Assessment Sciences, University Utrecht, Utrecht, the Netherlands.
Nino KünzliSwiss Tropical and Public Health Institute, Basel, Switzerland.
Bénédicte JacqueminINSERM U1168, VIMA: Aging and chronic diseases. Epidemiological and public health approaches, Villejuif, France.
Raphaëlle VarrasoINSERM U1168, VIMA: Aging and chronic diseases. Epidemiological and public health approaches, Villejuif, France.
Régis MatranUniv Lille et CHU de Lille, Lille, France.
Rachel NadifINSERM U1168, VIMA: Aging and chronic diseases. Epidemiological and public health approaches, Villejuif, France.ORCID 0000-0003-4938-9339
Inserm · FRCentre Hospitalier Universitaire de Lille · FRCentre National de la Recherche Scientifique · FRSichuan University · CNSwiss Tropical and Public Health Institute · CHUniversitat Pompeu Fabra · ESUniversité de Lille · FRUtrecht University · NL

Funding

ESCAPE [FP7/2007-2011, Grant Nr.211250].the National Hospital program of clinical research PHRC-national 2012, EvAdA
6 · The paper itself

Abstract

backgroundEvidences that oxidative stress plays a role in the associations between outdoor air pollution and asthma are growing. We aimed to study the role of plasma fluorescent oxidation products levels (FlOPs; an oxidative stress-related biomarker), as potential mediators, in the associations between outdoor air pollution and persistent asthma.

methodsAnalyses were conducted in 204 adult asthmatics followed up in the French case-control and family study on asthma (EGEA; the Epidemiological study of the Genetic and Environmental factors of Asthma). Persistent asthma was defined as having current asthma at EGEA2 (baseline, 2003-2007) and EGEA3 (follow-up, 2011-2013). Exposures to nitrogen dioxide, nitrogen oxides, road traffic, particulate matter with a diameter ≤ 10 μm (PM

resultsFlOPs levels increased with PM

conclusionsOur results add insights on the role of oxidative stress in the association between air pollution and persistent asthma.

Indexed as

Oxidative StressAdolescentAdultAgedAged, 80 and overAir PollutantsAir PollutionAsthmaBiomarkersCase-Control StudiesChronic DiseaseEnvironmental ExposureFemaleFollow-Up StudiesFranceHumansAir PollutantsBiomarkersEpidemiologyFluorescent oxidation productsMediation analysisOutdoor air pollutionOxidative stressPersistent asthma

Identifiers

PMID31665023
PMCPMC6819357
OpenAlexW2982362299

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.