Evidence map›Paper›PMID 31665018›Full record

ArticleMicrobial cell factories2019

A metabolic reconstruction of Lactobacillus reuteri JCM 1112 and analysis of its potential as a cell factory.

Thordis Kristjansdottir, Elleke F Bosma, Filipe Branco Dos Santos, Emre Özdemir, Markus J Herrgård, Lucas França, Bruno Ferreira, Alex T Nielsen, Steinn Gudmundsson

Open access · goldAbstract read
In one paragraph

Article in Microbial cell factories, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.

0numbers the graph read from it
0cells of the map it votes in
22citing papers in PubMed
2.1field-weighted citation impact, top 12% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

22 citing papers in PubMed, 41 citations in OpenAlex.

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  6. Fermentative production of vitamin BFood science & nutrition · 2024
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  10. NAR genomics and bioinformatics · 2024
    Article
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  15. Review
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  18. Probiogenomics ofMicroorganisms · 2021
    Article
  19. Review
  20. Two-species community design of lactic acid bacteria for optimal production of lactate.Computational and structural biotechnology journal · 2021
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 4 institutions in 4 countries.

Thordis KristjansdottirCenter for Systems Biology, School of Engineering and Natural Sciences, University of Iceland, Dunhagi 5, 107, Reykjavik, Iceland.ORCID http://orcid.org/0000-0003-2244-1723
Elleke F BosmaThe Novo Nordisk Foundation Center for Biosustainability, Technical University of Denmark, Building 220, Kemitorvet, 2800 Kgs., Lyngby, Denmark.ORCID http://orcid.org/0000-0001-6189-7753
Filipe Branco Dos SantosMolecular Microbial Physiology Group of the Swammerdam Institute for Life Sciences, University of Amsterdam, Science Park 904, 1098 XH, Amsterdam, The Netherlands.
Emre ÖzdemirThe Novo Nordisk Foundation Center for Biosustainability, Technical University of Denmark, Building 220, Kemitorvet, 2800 Kgs., Lyngby, Denmark.
Markus J HerrgårdThe Novo Nordisk Foundation Center for Biosustainability, Technical University of Denmark, Building 220, Kemitorvet, 2800 Kgs., Lyngby, Denmark.
Lucas FrançaBiotrend SA - Biocant Park, Núcleo 04, Lote 2, 3060-197, Cantanhede, Portugal.
Bruno FerreiraBiotrend SA - Biocant Park, Núcleo 04, Lote 2, 3060-197, Cantanhede, Portugal.
Alex T NielsenThe Novo Nordisk Foundation Center for Biosustainability, Technical University of Denmark, Building 220, Kemitorvet, 2800 Kgs., Lyngby, Denmark.
Steinn GudmundssonCenter for Systems Biology, School of Engineering and Natural Sciences, University of Iceland, Dunhagi 5, 107, Reykjavik, Iceland. steinng@hi.is.
Novo Nordisk Foundation · DKBiocant · PTUniversity of Iceland · ISUniversity of Amsterdam · NL

Funding

Horizon 2020 Research and Innovation 686070Marine Biotechnology ERA-NET 5178-00003BTechnology development fund in Iceland 159004-0612
6 · The paper itself

Abstract

backgroundLactobacillus reuteri is a heterofermentative Lactic Acid Bacterium (LAB) that is commonly used for food fermentations and probiotic purposes. Due to its robust properties, it is also increasingly considered for use as a cell factory. It produces several industrially important compounds such as 1,3-propanediol and reuterin natively, but for cell factory purposes, developing improved strategies for engineering and fermentation optimization is crucial. Genome-scale metabolic models can be highly beneficial in guiding rational metabolic engineering. Reconstructing a reliable and a quantitatively accurate metabolic model requires extensive manual curation and incorporation of experimental data.

resultsA genome-scale metabolic model of L. reuteri JCM 1112

conclusionWe have constructed a manually curated genome-scale metabolic model of L. reuteri JCM 1112

Indexed as

Limosilactobacillus reuteriMetabolic EngineeringFermentationProbioticsCell factoryGenome-scale metabolic modelLactobacillus reuteri

Identifiers

PMID31665018
PMCPMC6821008
OpenAlexW2982564330

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.