SynthesisRespiratory research2019
BMI is associated with FEV
Synthesis in Respiratory research, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 72 papers, 4 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
72 citing papers in PubMed, 4 syntheses or guidelines pooled it, 139 citations in OpenAlex.
- The impact of body mass index on mortality in COPD: an updated dose-response meta-analysis.European respiratory review : an official journal of the European Respiratory Society · 2024Pooled it
- Temporal Associations Among Body Mass Index, Fasting Insulin, and Systemic Inflammation: A Systematic Review and Meta-analysis.JAMA network open · 2021Pooled it
- Effects of Exercise Intervention on Peripheral Skeletal Muscle in Stable Patients With COPD: A Systematic Review and Meta-Analysis.Frontiers in medicine · 2021Pooled it
- Pooled it
- Efficacy and safety of physical therapy in patients with stage III COPD during ambulatory rehabilitation.Journal of medicine and life · 2023Trial
- Obesity in Chronic Obstructive Pulmonary Disease (COPD): Effects on Inflammation, Immune System, Susceptibility to Viral Infections, and Mortality.Pathogens (Basel, Switzerland) · 2026Article
- Long-term lung function decline from chronic workplace exposure in roadside vendors of Peshawar, Pakistan.Journal of public health research · 2026Article
- Change of frailty index and anthropometric indices in patients with chronic obstructive pulmonary disease.BMC pulmonary medicine · 2026Article
- From China's Multicenter Prospective Cohort: Right Ventricular Afterload and Prognosis in Hospitalized Patients with Acute Exacerbation of COPD.International journal of chronic obstructive pulmonary disease · 2026Article
- Comparison of Tools for Nutrition Assessment in Stable Subjects with Chronic Obstructive Pulmonary Disease: Which is the Best Mortality Predictor in Real Clinical Practice?International journal of chronic obstructive pulmonary disease · 2026Observational
- Article
- Leveraging Subjective Parameters and Biomarkers in Machine Learning Models: The Feasibility ofDiagnostics (Basel, Switzerland) · 2025Article
- Multimorbidity and its correlates in middle-aged and older adults in a city of North India.Journal of family medicine and primary care · 2025Article
- Therapeutic Management in Patients with Chronic Obstructive Pulmonary Disease Who Are Overweight or Obese: A Systematic Review and Meta-Analysis.Journal of clinical medicine · 2025Review
- Spirometric pattern and cardiovascular risk: a prospective study of 0.3 million Chinese never-smokers.The Lancet regional health. Western Pacific · 2025Article
- Canonical correlation analysis on the association between pulmonary function and obesity in early-onset COPD: CT-based body composition analysis.Frontiers in medicine · 2025Article
- Association Between Advanced Lung Cancer Inflammation Index and Mortality in US Adults with Chronic Obstructive Pulmonary Disease.International journal of chronic obstructive pulmonary disease · 2025Article
- Body Mass Index and Lung Function in Hospitalized Severe AECOPD Patients: Investigating Nonlinear Associations and the Role of Hemoglobin.International journal of chronic obstructive pulmonary disease · 2025Article
- Association between advanced lung cancer inflammation index and all-cause and cause-specific mortality among asthma patients: a cohort study.Frontiers in nutrition · 2025Article
- Association between body mass index and chronic obstructive pulmonary disease in young individuals: a nationwide population‑based cohort study.Scientific reports · 2024Article
12 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThere is considerable heterogeneity in the rate of lung function decline in chronic obstructive pulmonary disease (COPD), the determinants of which are largely unknown. Observational studies in COPD indicate that low body mass index (BMI) is associated with worse outcomes, and overweight/obesity has a protective effect - the so-called "obesity paradox". We aimed to determine the relationship between BMI and the rate of FEV
methodsWe performed a systematic review of the literature, and identified 5 randomized controlled trials reporting the association between BMI and FEV
resultsThe estimated rate of FEV
conclusionsThese novel findings support the obesity paradox in COPD: compared to normal BMI, low BMI is a risk factor for accelerated lung function decline, whilst high BMI has a protective effect. The relationship may be due to common but as-of-yet unknown causative factors; further investigation into which may reveal novel endotypes or targets for therapeutic intervention.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.