Evidence map›Paper›PMID 31664978›Full record

ArticleBMC public health2019

Inequality in uptake of isoniazid prevention therapy and Mantoux test among pregnant women with HIV in the Eastern Cape, South Africa.

Oladele Vincent Adeniyi, Nonkosi Selanto-Chairman, Eyitayo Omolara Owolabi, Anthony Idowu Ajayi, Dominique Kabengele Kayembe, Daniel Ter Goon, Avramovic Gordana, John Lambert

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in BMC public health, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
0.7field-weighted citation impact, top 29% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 7 citations in OpenAlex.

  1. Review
  2. Tuberculosis Preventive Treatment for Pregnant People With HIV in South Africa: A Modeling Analysis of Clinical Benefits and Risks.Clinical infectious diseases : an official publication of the Infectious Diseases Society of America · 2025
    Article
  3. Article
  4. Article
  5. Article
  6. Coverage of isoniazid preventive therapy among people living with HIV; A retrospective cohort study in Tanzania (2012-2016).International journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases · 2021
    Article
  7. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 3 institutions in 3 countries.

Oladele Vincent AdeniyiDepartment of Family Medicine & Rural Health, Faculty of Health Sciences, Walter Sisulu University, Mthatha/East London Hospital Complex, Cecilia Makiwane Hospital, East London, South Africa. vincoladele@gmail.com.
Nonkosi Selanto-ChairmanDepartment of Public Health, Faculty of Health Sciences, University of Fort Hare, East London, South Africa.
Eyitayo Omolara OwolabiDepartment of Nursing Sciences, Faculty of Health Sciences, University of Fort Hare, East London, South Africa.
Anthony Idowu AjayiDepartment of Sociology, Faculty of Social Sciences & Humanities, University of Fort Hare, East London, South Africa. ajayianthony@gmail.com.ORCID http://orcid.org/0000-0002-6004-3972
Dominique Kabengele KayembeDepartment of Family Medicine & Rural Health, Faculty of Health Sciences, Walter Sisulu University, Mthatha/East London Hospital Complex, Cecilia Makiwane Hospital, East London, South Africa.
Daniel Ter GoonDepartment of Nursing Sciences, Faculty of Health Sciences, University of Fort Hare, East London, South Africa.
Avramovic GordanaDepartment of Infectious Diseases, Medicine and Sexual Health. Mater, Rotunda and University College, Dublin, Ireland.
John LambertDepartment of Infectious Diseases, Medicine and Sexual Health. Mater, Rotunda and University College, Dublin, Ireland.
University of Fort Hare · ZACecilia Makiwane Hospital · ZAUniversity College Dublin · IE

Funding

Universiteit Stellenbosch Collaborative Capacity Enhancement through Engagement with Districts (SUCCEED)ViiV Healthcare The Positive Action Grant from ViiV Healthcare Limited granted to CC, JL & OVA
6 · The paper itself

Abstract

backgroundHIV-associated tuberculosis (TB) is a major cause of death among pregnant women in South Africa. Isoniazid prevention therapy (IPT) strategy was implemented in South Africa concurrently with life-long antiretroviral therapy (ART) to reduce the TB-associated morbidity and mortality in individuals living with HIV. This study assessed the extent of the implementation of IPT and the performance of the Mantoux test by geographic settings of health facilities and residences of pregnant women living with HIV in the Eastern Cape, South Africa.

methodsWe conducted a data analysis of 1709 pregnant women enrolled in the new electronic database of the prevention of mother-to-child transmission programme of the East London Prospective Cohort Study. Relevant data on place of residence and antenatal care, performance of the Mantoux test and subsequent initiation of IPT were obtained. Descriptive and inferential statistics were employed to analyse the geographical variations and accessibility to Mantoux test and IPT.

resultsThe analysis shows that Mantoux test was performed on 803 pregnant women (47%) with significant geographical variation. After controlling for relevant covariates, pregnant women who resided in rural areas (AOR:0.63; CI: 0.47-0.84) compared to those who resided in urban areas were significantly less likely to receive Mantoux test. The rate of uptake of IPT was 79% with significant geographic variations. In the unadjusted model, rural place of residence (UOR:0.68; CI: 0.49-0.96) was independently associated with lower likelihood of uptake of INH prophylaxis; however, the effect was not significant after controlling for important covariates.

conclusionsThe high uptake rate of isoniazid prevention therapy in pregnant women living with HIV at the study sites is commendable; however, concerted efforts are needed to address the inequality gaps in the roll-out of IPT. Poor performance of Mantoux test is a serious concern and requires the attention of TB programme managers and other relevant authorities.

Indexed as

Healthcare DisparitiesAdolescentAdultFemaleHIV InfectionsHumansInfectious Disease Transmission, VerticalIsoniazidMiddle AgedPregnancyPregnancy Complications, InfectiousProspective StudiesSouth AfricaTuberculin TestYoung AdultIsoniazidHIV-associated tuberculosisIsoniazid prevention therapyMantoux testMaternal mortalityTuberculosis-associated morbidityTuberculosis-associated mortality

Identifiers

PMID31664978
PMCPMC6819455
OpenAlexW2982469723

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.