ArticleAmerican journal of physiology. Regulatory, integrative and comparative physiology2020
The magnitude of the exercise pressor reflex is influenced by the active skeletal muscle mass in the decerebrate rat.
Article in American journal of physiology. Regulatory, integrative and comparative physiology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed.
- Lactate and hydrogen ions play a predominant role in evoking the exercise pressor reflex during ischaemic contractions but not during freely perfused contractions.The Journal of physiology · 2025Article
- Mechanism of heat treatment on exercise pressor reflex in hindlimb ischemia-reperfusion: Does the temperature gradient matter?Autonomic neuroscience : basic & clinical · 2025Article
- Dissecting the exercise pressor reflex in heart failure: A multi-step failure.Autonomic neuroscience : basic & clinical · 2025Review
- Abnormal cardiovascular control during exercise: Role of insulin resistance in the brain.Autonomic neuroscience : basic & clinical · 2025Review
- Hypertension restricts leg blood flow and aggravates neuromuscular fatigue during human locomotion in males.American journal of physiology. Regulatory, integrative and comparative physiology · 2024Article
- Hemodynamic responses to the cold pressor test in individuals with metabolic syndrome: a case-control study in a multiracial sample of adults.Journal of human hypertension · 2024Article
- Lower middle cerebral artery blood velocity during low-volume high-intensity interval exercise in chronic stroke.Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism · 2024Article
- Fat-free mass is associated with exercise pressor responses, but not cold pressor responses, in humans: influence of maximal voluntary contraction.Frontiers in sports and active living · 2024Article
- Various modalities of resistance exercise promote similar acute cognitive improvements and hemodynamic increases in young, healthy adults.Cerebral circulation - cognition and behavior · 2024Article
- The exercise pressor reflex - a pressure-raising mechanism with a limited role in regulating leg perfusion during locomotion in young healthy men.The Journal of physiology · 2023Article
- Neural discharge of muscle afferents and pressor response to mechanical stimulation are associated with muscle deformation velocity in rats.American journal of physiology. Regulatory, integrative and comparative physiology · 2023Article
- Age-related alterations in the cardiovascular responses to acute exercise in males and females: role of the exercise pressor reflex.Frontiers in physiology · 2023Review
- Exaggerated exercise pressor reflex in male UC Davis type 2 diabetic rats is due to the pathophysiology of the disease and not aging.Frontiers in physiology · 2022Article
- Muscle metaboreflex adaptations to exercise training in health and disease.European journal of applied physiology · 2021Review
- The muscle reflex and chemoreflex interaction: ventilatory implications for the exercising human.Journal of applied physiology (Bethesda, Md. : 1985) · 2020Article
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Authors and funding
3 authors.
Funding
Abstract
The exercise pressor reflex is composed of two components, namely the muscle mechanoreflex and the muscle metaboreflex. The afferents evoking the two components are either thinly myelinated (group III) or unmyelinated (group IV); in combination they are termed "thin fiber afferents." The exercise pressor reflex is often studied in unanesthetized, decerebrate rats. However, the relationship between the magnitude of this reflex and the number of thin fiber afferents stimulated by muscle contraction is unknown. This lack of knowledge prompted us to test the hypothesis that the magnitude of the exercise pressor reflex was directly proportional to the amount of muscle mass activated. Muscle mechanoreceptors were stimulated by stretching the calcaneal tendon. Likewise, muscle metaboreceptors were stimulated by injecting lactic acid into the arterial supply of the hindlimb muscles. In addition, both muscle mechanoreceptors and metaboreceptors were stimulated by statically contracting the hindlimb muscles. We found that simultaneous bilateral (both hindlimbs) stimulation of thin fiber afferents with stretch, lactic acid, and static contraction evoked significantly greater pressor responses than did unilateral (one hindlimb) stimulation of these afferents. In addition, the magnitude of the pressor responses to bilateral simultaneous stimulation of thin fiber afferents evoked by stretch, lactic acid, and contraction was not significantly different from the magnitude of the sum of the pressor responses evoked by unilateral stimulation of these afferents by stretch, lactic acid, and contraction. We conclude that the magnitude of the exercise pressor reflex and its two components is dependent on the number of afferents stimulated.
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