Evidence map›Paper›PMID 31664867›Full record

ArticleAmerican journal of physiology. Regulatory, integrative and comparative physiology2019

Investigating the utility of adult zebrafish ex vivo whole hearts to pharmacologically screen hERG channel activator compounds.

Christina M Hull, Christine E Genge, Yuki Hobbs, Kaveh Rayani, Eric Lin, Marvin Gunawan, Sanam Shafaattalab, Glen F Tibbits, Tom W Claydon

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in American journal of physiology. Regulatory, integrative and comparative physiology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. Article
  2. Frontiers in physiology · 2022
    Article
  3. Review
  4. The zebrafishProceedings of the National Academy of Sciences of the United States of America · 2021
    Article
  5. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Christina M HullDepartment of Biomedical Physiology and Kinesiology, Simon Fraser University, Burnaby, British Columbia, Canada.
Christine E GengeDepartment of Biomedical Physiology and Kinesiology, Simon Fraser University, Burnaby, British Columbia, Canada.
Yuki HobbsDepartment of Biomedical Physiology and Kinesiology, Simon Fraser University, Burnaby, British Columbia, Canada.
Kaveh RayaniDepartment of Biomedical Physiology and Kinesiology, Simon Fraser University, Burnaby, British Columbia, Canada.
Eric LinDepartment of Biomedical Physiology and Kinesiology, Simon Fraser University, Burnaby, British Columbia, Canada.
Marvin GunawanDepartment of Biomedical Physiology and Kinesiology, Simon Fraser University, Burnaby, British Columbia, Canada.
Sanam ShafaattalabDepartment of Biomedical Physiology and Kinesiology, Simon Fraser University, Burnaby, British Columbia, Canada.
Glen F TibbitsDepartment of Biomedical Physiology and Kinesiology, Simon Fraser University, Burnaby, British Columbia, Canada.
Tom W ClaydonDepartment of Biomedical Physiology and Kinesiology, Simon Fraser University, Burnaby, British Columbia, Canada.

Funding

CIHR
6 · The paper itself

Abstract

There is significant interest in the potential utility of small-molecule activator compounds to mitigate cardiac arrhythmia caused by loss of function of hERG1a voltage-gated potassium channels. Zebrafish (

Indexed as

AnimalsChlorobenzenesCresolsEther-A-Go-Go Potassium ChannelsGene Expression RegulationHeartHistamine H1 Antagonists, Non-SedatingOocytesortho-AminobenzoatesPhenethylaminesPhenylurea CompoundsPiperidinesPotassium Channel BlockersQuinolinesSulfonamidesTerfenadine1,3-bis(2-hydroxy-5-trifluoromethylphenyl)urea2-(4-(2-(3,4-dichlorophenyl)ethyl)phenylamino)benzoic acidChlorobenzenesCresolsdofetilideErg protein, zebrafishEther-A-Go-Go Potassium ChannelsHistamine H1 Antagonists, Non-Sedatingortho-AminobenzoatesPhenethylaminesPhenylurea CompoundsPiperidinesPotassium Channel BlockersQuinolinesRPR260243SulfonamidesTerfenadineZebrafish ProteinsactivatorshERGoptical mappingzebrafishzERGzkcnh6

Identifiers

PMID31664867
PMCPMC6962622

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.