ArticleAdvanced healthcare materials2019
3D Printed Microheater Sensor-Integrated, Drug-Encapsulated Microneedle Patch System for Pain Management.
Article in Advanced healthcare materials, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
18 citing papers in PubMed, 1 synthesis or guideline pooled it.
- The Efficacy of Intravenous Analgesia and Various Nerve Blocks for Pain Management in Elderly Patients With Hip Fractures: A Meta-Analysis.Orthopaedic surgery · 2025Pooled it
- Lab to Fab Process Using Ablation Lasers: A Lightweight, Flexible, and Biocompatible Microheater for Wearable Therapy Applications.ACS applied bio materials · 2025Article
- Progressive microneedles for targeting and intelligent drug delivery.Asian journal of pharmaceutical sciences · 2025Review
- Stretchable multifunctional wearable system for real-time and on-demand thermotherapy of arthritis.Microsystems & nanoengineering · 2025Article
- A bio-feedback-mimicking electrode combining real-time monitoring and drug delivery.Innovation (Cambridge (Mass.)) · 2024Article
- High-Performance, Easy-to-Fabricate, Nanocomposite Heater for Life Sciences and Biomedical Applications.Polymers · 2024Article
- Advancements in Skin-Mediated Drug Delivery: Mechanisms, Techniques, and Applications.Advanced healthcare materials · 2024Review
- Design and fabrication of customizable microneedles enabled by 3D printing for biomedical applications.Bioactive materials · 2024Review
- Development and Prospective Applications of 3D Membranes as a Sensor for Monitoring and Inducing Tissue Regeneration.Membranes · 2023Review
- Recent Advances in Bioinspired Hydrogels: Materials, Devices, and Biosignal Computing.ACS biomaterials science & engineering · 2023Review
- 3D-Printed Microinjection Needle Arrays via a Hybrid DLP-Direct Laser Writing Strategy.Advanced materials technologies · 2023Article
- 3D printing and 3D-printed electronics: Applications and future trends in smart drug delivery devices.International journal of bioprinting · 2023Article
- Recent Progress of Triboelectric Nanogenerators for Biomedical Sensors: From Design to Application.Biosensors · 2022Review
- 3D-Printed Microneedles for Point-of-Care Biosensing Applications.Micromachines · 2022Article
- Design and fabrication of r-hirudin loaded dissolving microneedle patch for minimally invasive and long-term treatment of thromboembolic disease.Asian journal of pharmaceutical sciences · 2022Article
- Microheater: material, design, fabrication, temperature control, and applications-a role in COVID-19.Biomedical microdevices · 2021Review
- Polyvinylpyrrolidone microneedles for localized delivery of sinomenine hydrochloride: preparation, release behavior ofDrug delivery · 2020Article
- Microneedle-based bioassays.Nanoscale advances · 2020Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
9 authors.
Funding
Abstract
Microneedle patch devices have been widely utilized for transdermal drug delivery in pain management, but is challenged by accurate control of drug release and subsequent diffusion to human body. The recent emerging wearable electronics that could be integrated with microneedle devices offer a facile approach to address such a challenge. Here a 3D-printed microheater integrated drug-encapsulated microneedle patch system for drug delivery is presented. The ink solution comprised polydimethylsiloxane (PDMS) and multiwalled carbon nanotubes (MWCNTs) with a mass concentration of up to 45% (≈10 times higher of existing ones) is prepared and used to print crack-free stretchable microheaters on substrates with a broad range of materials and geometric curves. The adhesion strength of the printed microheater on the microneedle patch in elevated temperatures is measured to evaluate their integration performance. Assessments of encapsulated drug release into rat's skin are confirmed by examining degradation of microneedles, skin morphologies, and released fluorescent signals. Results and demonstrations established here creates a new opportunity for developing sensor controlled smart microneedle patch systems by integrating with wearable electronics, potentially useful in clinical and biomedical research.
Indexed as
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.