ArticleMolecular biotechnology2019
Structural Characterization of Open Reading Frame-Encoded Functional Genes from Tilapia Lake Virus (TiLV).
Article in Molecular biotechnology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed, 51 citations in OpenAlex.
- Uncovering host transcriptional responses to tilapia lake virus (TiLV) through De novo RNA-seq assembly in Nile tilapia, Oreochromis niloticus.Archives of virology · 2026Article
- Phylogenetic and Proteomic Analyses of Segment 2 Sequence Reveals the Presence of Two Variants of a Divergent Amnoonvirus (Family:Microorganisms · 2026Article
- Genome sequencing and analysis of kuchijirosho virus identify it as a novel member of the family Amnoonviridae within the order Articulavirales.Archives of virology · 2026Article
- Characterisation of the tilapia lake virus proteome and identification of an 11th protein, S9-F3.Npj viruses · 2026Article
- Design of antibody structure-guided epitope vaccinesJournal of virology · 2025Article
- Exploring the Virome of Nile Tilapia (Pathogens (Basel, Switzerland) · 2025Article
- Evolution and Comparative Genomics of the Transforming Growth Factor-β-Related Proteins in Nile Tilapia.Molecular biotechnology · 2025Article
- Pathological effects and immune modulation in host during Tilapia Parvovirus (TiPV) outbreak in cage and wetland Tilapia farms.Scientific reports · 2024Article
- ICTV Virus Taxonomy Profile:The Journal of general virology · 2023Article
- Immune responses to Tilapia lake virus infection: what we know and what we don't know.Frontiers in immunology · 2023Review
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- AttenuatedFrontiers in microbiology · 2022Article
- Combining segments 9 and 10 in DNA and recombinant protein vaccines conferred superior protection against tilapia lake virus in hybrid red tilapia (Frontiers in immunology · 2022Article
- Sterile alpha and TIR motif-containing protein 1 is a negative regulator in the anti-bacterial immune responses in nile tilapia (Frontiers in immunology · 2022Article
- Rapid genotyping of tilapia lake virus (TiLV) using Nanopore sequencing.Journal of fish diseases · 2021Article
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Corrections and comments
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Authors and funding
6 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
In recent years, large-scale mortalities are observed in tilapia due to infection with a novel orthomyxo-like virus named, tilapia lake virus (TiLV) which is marked to be a severe threat to universal tilapia industry. Currently, there are knowledge gaps relating to the antiviral peptide as well as there are no affordable vaccines or drugs available against TiLV yet. To understand the spreading of infection of TiLV in different organs of Oreochromis niloticus, RT-PCR analysis has been carried out. The gene segments of TiLV were retrieved from the NCBI database for computational biology analysis. The 14 functional genes were predicted from the 10 gene segments of TiLV. Phylogenetic analysis was employed to find out a better understanding for the evolution of tilapia lake virus genes. Out of 14 proteins, only six proteins show transmembrane helix region. Moreover, molecular modeling and molecular dynamics simulations of the predicted proteins revealed structural stability of the protein stabilized after 10-ns simulation. Overall, our study provided a basic bioinformatics on functional proteome of TiLV. Further, this study could be useful for development of novel peptide-based therapeutics to control TiLV infection.
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