ArticleJapanese journal of radiology2020
Early volume reduction of the hippocampus after whole-brain radiation therapy: an automated brain structure segmentation study.
Article in Japanese journal of radiology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed.
- Association of regional specificity of blood-brain barrier permeability with pathological subtypes in cerebral white matter of patients with non-brain metastatic lung cancer.Frontiers in oncology · 2026Article
- Hippocampal Atrophy Following Therapeutic Irradiation of Intracranial and Nasopharyngeal Tumors.Cureus · 2025Review
- Ex vivo brain MRI to assess conventional and FLASH brain irradiation effects.Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology · 2025Article
- Central Nervous System Response Against Ionizing Radiation Exposure: Cellular, Biochemical, and Molecular Perspectives.Molecular neurobiology · 2025Review
- Differentiating unirradiated mice from those exposed to conventional or FLASH radiotherapy using MRI.bioRxiv : the preprint server for biology · 2025Article
- Partial hippocampal avoidance whole brain radiotherapy in a patient with metastatic infiltration of the left hippocampus.BMJ case reports · 2023Article
- Article
- Salvage craniospinal irradiation for recurrent intracranial germinoma: a single institution analysis.Journal of radiation research · 2023Article
- Clinical Application of MPRAGE Wave Controlled Aliasing in Parallel Imaging (Wave-CAIPI): A Comparative Study with MPRAGE GRAPPA.Magnetic resonance in medical sciences : MRMS : an official journal of Japan Society of Magnetic Resonance in Medicine · 2022Article
- Time- and dose-dependent volume decreases in subcortical grey matter structures of glioma patients after radio(chemo)therapy.Clinical and translational radiation oncology · 2022Article
- Overestimation of grey matter atrophy in glioblastoma patients following radio(chemo)therapy.Magma (New York, N.Y.) · 2022Article
- Early postnatal irradiation-induced age-dependent changes in adult mouse brain: MRI based characterization.BMC neuroscience · 2021Article
- Review
- Review
- Optimizing Adjuvant Stereotactic Radiotherapy of Motor-Eloquent Brain Metastases: Sparing the nTMS-Defined Motor Cortex and the Hippocampus.Frontiers in oncology · 2021Article
- Late toxicity in the brain after radiotherapy for sinonasal cancer: Neurocognitive functioning, MRI of the brain and quality of life.Clinical and translational radiation oncology · 2020Article
- Precision Radiotherapy for Gliomas: Implementing Novel Imaging Biomarkers to Improve Outcomes With Patient-Specific Therapy.Cancer journal (Sudbury, Mass.)Article
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Authors and funding
10 authors.
Funding
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Abstract
purposeTo assess atrophy differences among brain regions and time-dependent changes after whole-brain radiation therapy (WBRT). MATERIALS AND
methodsTwenty patients with lung cancer who underwent both WBRT and chemotherapy (WBRT group) and 18 patients with lung cancer who underwent only chemotherapy (control group) were recruited. Three-dimensional T1WI were analyzed to calculate volume reduction ratio after WBRT in various brain structures. The volume reduction ratio of the hippocampus was compared among following 3 periods: 0-3, 4-7, and 8-11 months after WBRT.
resultsThe volume reduction ratio of the hippocampus was significantly higher in the WBRT group than in the control group (p < 0.05). In WBRT group, the volume reduction ratio of the hippocampus was significantly higher than that of the cortex and white matter (p < 0.05). There were significant differences in the volume reduction ratio between of 0-3 months and that of 4-7 months (p = 0.02) and between 4-7 months and that of 8-11 months (p = 0.01).
conclusionThe hippocampus is more vulnerable to the radiation compared with other brain regions and may become atrophic even in the early stage after WBRT.
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