Evidence map›Paper›PMID 31664630›Full record

ArticleJapanese journal of ophthalmology2019

Clinical characteristics of cuticular drusen in the Japanese population.

Yoichi Sakurada, Koji Tanaka, Akiko Miki, Hidetaka Matsumoto, Akiyuki Kawamura, Ryo Mukai, Hideo Akiyama, Shigeru Honda, Ryusaburo Mori, Hiroyuki Iijima

Abstract readMulticenter Study
PubMed Publisher
In one paragraph

Article in Japanese journal of ophthalmology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
1.7field-weighted citation impact, top 17% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 10 citations in OpenAlex.

  1. Cuticular drusen in Asian neovascular age-related macular degeneration: Clinical features and polypoidal choroidal vasculopathy association.Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie · 2026
    Article
  2. Bilateral multiple retinal pigment epithelial detachments.Documenta ophthalmologica. Advances in ophthalmology · 2025
    Article
  3. Article
  4. Clinical Manifestations of Cuticular Drusen: Current Perspectives.Clinical ophthalmology (Auckland, N.Z.) · 2021
    Review
  5. Article
  6. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 5 institutions in 1 country.

Yoichi SakuradaDepartment of Ophthalmology, Faculty of Medicine, University of Yamanashi, Shimokato 1110, Chuo, Yamanashi, 409-3821, Japan. sakurada@yamanashi.ac.jp.
Koji TanakaDivision of Ophthalmology, Department of Visual Sciences, Nihon University School of Medicine, Tokyo, Japan.
Akiko MikiDivision of Ophthalmology, Department of Surgery, Kobe University Graduate School of Medicine, Hyogo, Japan.
Hidetaka MatsumotoDepartment of Ophthalmology, Gunma University School of Medicine, Gunma, Japan.
Akiyuki KawamuraDivision of Ophthalmology, Department of Visual Sciences, Nihon University School of Medicine, Tokyo, Japan.
Ryo MukaiDepartment of Ophthalmology, Gunma University School of Medicine, Gunma, Japan.
Hideo AkiyamaDepartment of Ophthalmology, Gunma University School of Medicine, Gunma, Japan.
Shigeru HondaDepartment of Ophthalmology and Visual Sciences, Osaka City University, Graduate School of Medicine, Osaka, Japan.
Ryusaburo MoriDivision of Ophthalmology, Department of Visual Sciences, Nihon University School of Medicine, Tokyo, Japan.
Hiroyuki IijimaDepartment of Ophthalmology, Faculty of Medicine, University of Yamanashi, Shimokato 1110, Chuo, Yamanashi, 409-3821, Japan.
Gunma University · JPNihon University · JPUniversity of Yamanashi Hospital · JPKobe University · JPOsaka City University · JP

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeTo investigate the clinical characteristics of eyes with cuticular drusen in Japanese individuals, while paying special attention to large colloid drusen (LCD). STUDY

designRetrospective case series.

methodsEyes with cuticular drusen, from patients of 4 medical institutes in Japan, were investigated. Multimodal imaging findings were used to diagnose cuticular drusen. LCD was defined as cuticular drusen > 200 µm.

resultsTwenty-four eyes from 12 patients (8 women, 4 men) were diagnosed with cuticular drusen. The mean age of all patients (n = 12) was 60.8 years. The mean age of patients without additional macular pathology (n = 5) was 55.4 years. Of the 7 patients with additional macular pathology, 6 (85.7%) exhibited age-related macular degeneration-associated macular pathology, including drusenoid pigment epithelial detachment (PED) (8 eyes from 4 patients), geographic atrophy (2 eyes from 1 patient), and occult choroidal neovascularization (1 eye). LCD were found in 6 eyes of 3 patients (25%), those with LCD were on average 53.7 ± 8.7 years old and those without 69.9 ± 14.1 years of age (P = 0.064, Mann-Whitney U test).

conclusionsCuticular drusen were predominantly seen in females, and drusenoid PED was most frequently seen in eyes with additional macular pathology. LCD were seen in 25% of eyes with cuticular drusen.

Indexed as

AdultAgedAged, 80 and overFemaleFluorescein AngiographyFundus OculiHumansIncidenceJapanMaleMiddle AgedRetinaRetinal DrusenRetrospective StudiesSex FactorsTomography, Optical CoherenceAge-related macular degenerationCuticular drusenDrusenoid pigment epithelial detachmentLarge colloid drusen

Identifiers

PMID31664630
OpenAlexW2982582842

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.