Evidence map›Paper›PMID 31664621›Full record

Observational studyAnnals of surgical oncology2020

Perioperative Blood Transfusion is Associated with Postoperative Systemic Inflammatory Response and Poorer Outcomes Following Surgery for Colorectal Cancer.

Stephen T McSorley, Alexander Tham, Ross D Dolan, Colin W Steele, Jason Ramsingh, Campbell Roxburgh, Paul G Horgan, Donald C McMillan

Abstract readObservational Study
PubMed Full text at PMC Publisher
In one paragraph

Observational study in Annals of surgical oncology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 44 papers, 5 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
44citing papers in PubMed, 5 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

44 citing papers in PubMed, 5 syntheses or guidelines pooled it.

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  5. [Evidence of minimally invasive oncological surgery of the liver].Der Chirurg; Zeitschrift fur alle Gebiete der operativen Medizen · 2021
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Stephen T McSorleyAcademic Unit of Surgery, University of Glasgow, Glasgow, UK. s.mcsorley@doctors.org.uk.ORCID http://orcid.org/0000-0002-5459-8445
Alexander ThamAcademic Unit of Surgery, University of Glasgow, Glasgow, UK.
Ross D DolanAcademic Unit of Surgery, University of Glasgow, Glasgow, UK.
Colin W SteeleAcademic Unit of Surgery, University of Glasgow, Glasgow, UK.
Jason RamsinghAcademic Unit of Surgery, University of Glasgow, Glasgow, UK.
Campbell RoxburghAcademic Unit of Surgery, University of Glasgow, Glasgow, UK.
Paul G HorganAcademic Unit of Surgery, University of Glasgow, Glasgow, UK.
Donald C McMillanAcademic Unit of Surgery, University of Glasgow, Glasgow, UK.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundThe present study investigated relationships between perioperative blood transfusion, postoperative systemic inflammatory response, and outcomes following surgery for colorectal cancer.

methodsData were recorded for patients (n = 544) undergoing potentially curative, elective surgery for colorectal cancer at a single center between 2012 and 2017. Transfusion history was obtained retrospectively from electronic records. Associations between blood transfusion, postoperative C-reactive protein (CRP), albumin, hemoglobin, complications, cancer-specific survival and overall survival (OS) were assessed using propensity score matching (n =116).

resultsOf 544 patients, the majority were male (n =294, 54%), over 65 years of age (n =350, 64%), and with colonic (n =347, 64%) node-negative disease (n =353, 65%). Eighty-six patients (16%) required perioperative blood transfusion. In the unmatched cohort, blood transfusion was associated with higher median postoperative day (POD) 3 CRP {143 [interquartile range (IQR) 96-221 mg/L] vs. 120 (IQR 72-188 mg/L); p = 0.004}, lower median POD 3 albumin [24 (IQR 20-26 g/L) vs. 27 (IQR 24-30 g/L); p < 0.001], more postoperative complications [odds ratio (OR) 3.28, 95% confidence interval (CI) 2.03-5.29] and poorer OS [hazard ratio (HR) 3.18, 95% CI 2.08-4.84]. In the propensity score matched cohort, blood transfusion was similarly associated with higher median POD 3 CRP [130 (IQR 93-196 mg/L) vs. 113 (IQR 66-173 mg/L); p = 0.046], lower median POD 3 albumin [24 (IQR 20-26 g/L) vs. 26 (IQR 24-30 g/L); p < 0.001], more postoperative complications (OR 2.91, 95% CI 1.36-6.20) and poorer OS (HR 2.38, 95% CI 0.99-5.73).

conclusionsPerioperative blood transfusion was associated with postoperative inflammation, complications, and poorer survival in patients undergoing colorectal cancer surgery, with and without propensity score techniques.

Indexed as

AgedBlood TransfusionColorectal NeoplasmsColorectal SurgeryFemaleFollow-Up StudiesHumansMalePostoperative ComplicationsPrognosisRetrospective StudiesSurvival RateSystemic Inflammatory Response SyndromeUnited Kingdom

Identifiers

PMID31664621
PMCPMC7000540

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.