Evidence map›Paper›PMID 31664501›Full record

Observational studyIntensive care medicine2019

Epidemiology of intra-abdominal infection and sepsis in critically ill patients: "AbSeS", a multinational observational cohort study and ESICM Trials Group Project.

Stijn Blot, Massimo Antonelli, Kostoula Arvaniti, Koen Blot, Ben Creagh-Brown, Dylan de Lange, Jan De Waele, Mieke Deschepper, Yalim Dikmen, George Dimopoulos and 16 more

Registry-linked trialOpen access · hybridAbstract readMulticenter StudyObservational Study
PubMed Full text at PMC Publisher
In one paragraph

Observational study in Intensive care medicine, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT07167173 (Predictive Model for Multidrug Resistance in Patients Admitted to the Emergency Department With Sepsis), which is not on this map. Cited by 91 papers, 7 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
91citing papers in PubMed, 7 pooled it
12.0field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT07167173 not yet recruitingnot on this mapstarted 2025, after this paper: background citation

Predictive Model for Multidrug Resistance in Patients Admitted to the Emergency Department With Sepsis

TypeobservationalSponsorHospital Italiano de Buenos AiresRan2025 to 2025Enrolled10,000ConditionsSepsis, Septic Shock
3 · Its place in the literature

Who cites it

91 citing papers in PubMed, 7 syntheses or guidelines pooled it, 190 citations in OpenAlex.

  1. Pooled it
  2. [Early source control of infection in patients seen in the emergency department: a systematic review].Revista espanola de quimioterapia : publicacion oficial de la Sociedad Espanola de Quimioterapia · 2024
    Pooled it
  3. Pooled it
  4. Pooled it
  5. Guideline
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  7. Pooled it
  8. Trial
  9. Article
  10. Article
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  12. Article
  13. Observational
  14. Article
  15. Prognostic impact ofAnnals of intensive care · 2026
    Article
  16. Review
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  18. Article
  19. Article
  20. Article

31 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

26 authors at 16 institutions in 13 countries.

Stijn BlotDepartment of Internal Medicine and Pediatrics, Ghent University, Campus UZ Gent, Corneel Heymanslaan 10, 9000, Ghent, Belgium. stijn.blot@UGent.be.ORCID http://orcid.org/0000-0003-2145-0345
Massimo AntonelliDepartment of Anesthesiology, Intensive Care and Emergency Medicine, Fondazione Policlinico Universitario A. Gemelli IRCCS, Rome, Italy.
Kostoula ArvanitiIntensive Care Unit, Papageorgiou University Affiliated Hospital, Thessaloníki, Greece.
Koen BlotDepartment of Internal Medicine and Pediatrics, Ghent University, Campus UZ Gent, Corneel Heymanslaan 10, 9000, Ghent, Belgium.
Ben Creagh-BrownSurrey Perioperative Anaesthetic Critical Care Collaborative Research Group (SPACeR), Royal Surrey County Hospital, Guildford, UK.
Dylan de LangeDepartment of Intensive Care Medicine, University Medical Center Utrecht, University Utrecht, Utrecht, The Netherlands.
Jan De WaeleDepartment of Critical Care Medicine, Ghent University Hospital, Ghent, Belgium.
Mieke DeschepperStrategic Policy Cell, Ghent University Hospital, Ghent, Belgium.
Yalim DikmenDepartment of Anesthesiology and Reanimation, Cerrahpasa School of Medicine, Istanbul University-Cerrahpasa, Istanbul, Turkey.
George DimopoulosCritical Care Department, University Hospital ATTIKON, National and Kapodistrian University of Athens, Athens, Greece.
Christian EckmannDepartment of General, Visceral and Thoracic Surgery, Klinikum Peine, Medical University Hannover, Hannover, Germany.
Guy FrancoisDivision of Scientific Affairs-Research, European Society of Intensive Care Medicine, Brussels, Belgium.
Massimo GirardisAnesthesia and Intensive Care Department, University Hospital of Modena, Modena, Italy.
Despoina KoulentiBurns, Trauma and Critical Care Research Centre, Centre for Clinical Research, Faculty of Medicine, The University of Queensland, Brisbane, Australia.
Sonia LabeauDepartment of Internal Medicine and Pediatrics, Ghent University, Campus UZ Gent, Corneel Heymanslaan 10, 9000, Ghent, Belgium.
Jeffrey LipmanRoyal Brisbane and Women's Hospital, The University of Queensland, Brisbane, Australia.
Fernando LipovestkyCritical Care Department, Hospital of the Interamerican Open University (UAI), Buenos Aires, Argentina.
Emilio MasedaSurgical Critical Care, Department of Anesthesia, Hospital Universitario La Paz-IdiPaz, Madrid, Spain.
Philippe MontraversUniversité de Paris, INSERM, UMR 1152, Paris, France.
Adam MikstackiFaculty of Health Sciences, Poznan University of Medical Sciences, Poznan, Poland.
José-Artur PaivaIntensive Care Department, Faculty of Medicine, Centro Hospitalar Universitario S. Joao, University of Porto, Grupo Infecçao e Sepsis, Porto, Portugal.
Cecilia PereyraIntensive Care Unit from Hospital Interzonal General de Agudos "Prof Dr Luis Guemes", Buenos Aires, Argentina.
Jordi RelloCiberes and Vall d'Hebron Institute of Research, Barcelona, Spain.
Jean-Francois TimsitUniversité de Paris, IAME, INSERM, Paris, 75018, France.
Dirk VogelaersGeneral Internal Medicine, Infectious Diseases, and Psychometric Medicine, Ghent University Hospital, Ghent, Belgium.
Abdominal Sepsis Study (AbSeS) group on behalf of the Trials Group of the European Society of Intensive Care Medicine
Ghent University Hospital · BEInserm · FRNational and Kapodistrian University of Athens · GRUniversity College Ghent · BEUniversity of Modena and Reggio Emilia · ITUtrecht University · NLAgostino Gemelli University Polyclinic · ITEl Hospital General de Agudos Carlos G. Durand · ARHospital Universitario La Paz · ESKlinikum Region Hannover · DEPoznan University of Medical Sciences · PLRoyal Surrey County Hospital · GBThe University of Queensland · AUUniversidade do Porto · PTUniversità Cattolica del Sacro Cuore · ITUniversité Claude Bernard Lyon 1 · FR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeTo describe the epidemiology of intra-abdominal infection in an international cohort of ICU patients according to a new system that classifies cases according to setting of infection acquisition (community-acquired, early onset hospital-acquired, and late-onset hospital-acquired), anatomical disruption (absent or present with localized or diffuse peritonitis), and severity of disease expression (infection, sepsis, and septic shock).

methodsWe performed a multicenter (n = 309), observational, epidemiological study including adult ICU patients diagnosed with intra-abdominal infection. Risk factors for mortality were assessed by logistic regression analysis.

resultsThe cohort included 2621 patients. Setting of infection acquisition was community-acquired in 31.6%, early onset hospital-acquired in 25%, and late-onset hospital-acquired in 43.4% of patients. Overall prevalence of antimicrobial resistance was 26.3% and difficult-to-treat resistant Gram-negative bacteria 4.3%, with great variation according to geographic region. No difference in prevalence of antimicrobial resistance was observed according to setting of infection acquisition. Overall mortality was 29.1%. Independent risk factors for mortality included late-onset hospital-acquired infection, diffuse peritonitis, sepsis, septic shock, older age, malnutrition, liver failure, congestive heart failure, antimicrobial resistance (either methicillin-resistant Staphylococcus aureus, vancomycin-resistant enterococci, extended-spectrum beta-lactamase-producing Gram-negative bacteria, or carbapenem-resistant Gram-negative bacteria) and source control failure evidenced by either the need for surgical revision or persistent inflammation.

conclusionThis multinational, heterogeneous cohort of ICU patients with intra-abdominal infection revealed that setting of infection acquisition, anatomical disruption, and severity of disease expression are disease-specific phenotypic characteristics associated with outcome, irrespective of the type of infection. Antimicrobial resistance is equally common in community-acquired as in hospital-acquired infection.

Indexed as

Cause of DeathAgedCohort StudiesCritical IllnessEpidemiologic StudiesFemaleHumansIntraabdominal InfectionsMaleMiddle AgedRisk FactorsSepsisIntensive careIntra-abdominal infectionMortalityMultidrug resistancePeritonitisSepsis

Identifiers

PMID31664501
PMCPMC6863788
OpenAlexW2982640231

What OpenQuestion holds

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LicenceCC BY-NC
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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.