Evidence map›Paper›PMID 31664180›Full record

ArticleScientific reports2019

Allogeneic dendritic cells induce potent antitumor immunity by activating KLRG1

Chao Wang, Zhengyuan Li, Zhongli Zhu, Yijie Chai, Yiqing Wu, Zhenglong Yuan, Zhijie Chang, Zhao Wang, Minghui Zhang

Open access · goldAbstract read
In one paragraph

Article in Scientific reports, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
0.4field-weighted citation impact, top 37% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 17 citations in OpenAlex.

  1. The theory of the inflammatory ecosystem.Science China. Life sciences · 2026
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  5. Human γδ T cells induce CD8Cancer immunology, immunotherapy : CII · 2023
    Article
  6. Article
  7. Review
  8. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 3 institutions in 1 country.

Chao WangSchool of Medicine, Tsinghua University, Beijing, 100084, China.
Zhengyuan LiSchool of Medicine, Tsinghua University, Beijing, 100084, China.
Zhongli ZhuDepartment of Clinical Laboratory, The Second Affiliated Hospital of Shandong First Medical University, Tai'an, Shandong, 271000, China.
Yijie ChaiSchool of Medicine, Tsinghua University, Beijing, 100084, China.
Yiqing WuSchool of Medicine, Tsinghua University, Beijing, 100084, China.
Zhenglong YuanSchool of Medicine, Tsinghua University, Beijing, 100084, China.
Zhijie ChangState Key Laboratory of Biomembrane and Membrane Biotechnology, School of Medicine, School of Life Sciences, Tsinghua University, Beijing, 100084, China. zhijiec@tsinghua.edu.cn.ORCID http://orcid.org/0000-0003-1567-3227
Zhao WangProtein Science Key Laboratory of the Ministry of Education, School of Pharmaceutical Sciences, Tsinghua University, Beijing, 100084, China. zwang@tsinghua.edu.cn.
Minghui ZhangSchool of Medicine, Tsinghua University, Beijing, 100084, China. mh-zhang@mail.tsinghua.edu.cn.
Tsinghua University · CNAffiliated Hospital of Taishan Medical University · CNBeijing Hua Xin Hospital · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The graft-versus-leukemia effect reminds us to observe the allogeneic cell elicited anti-tumor immune responses. Here we immunized recipient B6 mice with different types of allogenic leukocytes and found that vaccination with allogenic dendritic cells (alloDC) elicited the most efficient protection against broad-spectrum tumors. The recipient lymphocytes were analyzed and the data showed that CD8 T cells increased significantly after immunization and expressed effector memory T cell marker KLRG1. Functional evaluation demonstrated that these KLRG1

Indexed as

Adoptive TransferDendritic CellsImmunity, CellularAllograftsAnimalsCD8-Positive T-LymphocytesCell Line, TumorLectins, C-TypeMiceMice, KnockoutNeoplasms, ExperimentalReceptors, ImmunologicKlrg1 protein, mouseLectins, C-TypeReceptors, Immunologic

Identifiers

PMID31664180
PMCPMC6820535
OpenAlexW2982323204

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.