ArticleScientific reports2019
Dynamically changing neuronal activity supporting working memory for predictable and unpredictable durations.
Article in Scientific reports, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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Who cites it
18 citing papers in PubMed.
- Prefrontal parvalbumin neurons mediate working memory in a task demand-dependent manner.Nature communications · 2026Article
- Contextual inference through flexible integration of environmental features and behavioural outcomes.PLoS computational biology · 2026Article
- Hippocampal sequences represent working memory and implicit timing.Cell reports · 2025Article
- Cortical VIP neurons as a critical node for dopamine actions.Science advances · 2025Article
- Automating licking bias correction in a two-choice delayed match-to-sample task to accelerate learning.Scientific reports · 2023Article
- Time for Memories.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2023Article
- Striatum-projecting prefrontal cortex neurons support working memory maintenance.Nature communications · 2023Article
- Multiplexing working memory and time in the trajectories of neural networks.Nature human behaviour · 2023Article
- Distinct hippocampal-prefrontal neural assemblies coordinate memory encoding, maintenance, and recall.Current biology : CB · 2023Article
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- Slow manifolds within network dynamics encode working memory efficiently and robustly.PLoS computational biology · 2021Article
- Parallel processing of working memory and temporal information by distinct types of cortical projection neurons.Nature communications · 2021Article
- Neural Substrates of Visual Perception and Working Memory: Two Sides of the Same Coin or Two Different Coins?Frontiers in neural circuits · 2021Review
- Modeling Working Memory in a Spiking Neuron Network Accompanied by Astrocytes.Frontiers in cellular neuroscience · 2021Article
- Active maintenance of eligibility trace in rodent prefrontal cortex.Scientific reports · 2020Article
- Using rat operant delayed match-to-sample task to identify neural substrates recruited with increased working memory load.Learning & memory (Cold Spring Harbor, N.Y.) · 2020Article
- [Review of cognitive enhancement techniques based on the combination of cognitive training and transcranial direct current stimulation].Sheng wu yi xue gong cheng xue za zhi = Journal of biomedical engineering = Shengwu yixue gongchengxue zazhi · 2020Review
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Authors and funding
4 authors.
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No grant is acknowledged in the PubMed record.
Abstract
Diverse neural processes have been proposed as the neural basis of working memory. To investigate whether the medial prefrontal cortex (mPFC) relies on different neural processes to mediate working memory depending on the predictability of delay duration, we examined mPFC neural activity in mice performing a delayed response task with fixed (4 s) or random (between 1-7 s) delay durations. mPFC neural activity was strongly influenced by the predictability of delay duration. Nevertheless, mPFC neurons seldom showed persistent activity spanning the entire delay period and instead showed dynamically-changing delay-period activity under both the fixed-delay and random-delay conditions. mPFC neurons conveyed higher working memory information under the random-delay than fixed-delay conditions, possibly due to a higher demand for stable working memory maintenance. Our results suggest that the rodent mPFC may rely on dynamically-changing neuronal activity to maintain working memory regardless of the predictability of delay duration.
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