Evidence map›Paper›PMID 31664127›Full record

ArticleScientific reports2019

Novel dihydroartemisinin dimer containing nitrogen atoms inhibits growth of endometrial cancer cells and may correlate with increasing intracellular peroxynitrite.

Yan Zhu, Christian Klausen, Jieyun Zhou, Xiangjie Guo, Yu Zhang, Hua Zhu, Zhao Li, Jung-Chien Cheng, Shuwu Xie, Wenjie Yang and 2 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Scientific reports, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
0.6field-weighted citation impact, top 39% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 16 citations in OpenAlex.

  1. Article
  2. Article
  3. Small molecule probes for peroxynitrite detection.Redox biochemistry and chemistry · 2024
    Article
  4. Article
  5. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 3 institutions in 2 countries.

Yan ZhuLaboratory of Reproductive Pharmacology, Shanghai Institute of Planned Parenthood Research; Key Lab. of Reproduction Regulation of NPFPC, SIPPR, IRD, Fudan University, Shanghai, 200032, China. zhuyan@sippr.org.
Christian KlausenDepartment of Obstetrics and Gynaecology, BC Children's Hospital Research Institute, University of British Columbia, Vancouver, British Columbia, V5Z 4H4, Canada.
Jieyun ZhouLaboratory of Reproductive Pharmacology, Shanghai Institute of Planned Parenthood Research; Key Lab. of Reproduction Regulation of NPFPC, SIPPR, IRD, Fudan University, Shanghai, 200032, China.
Xiangjie GuoLaboratory of Reproductive Pharmacology, Shanghai Institute of Planned Parenthood Research; Key Lab. of Reproduction Regulation of NPFPC, SIPPR, IRD, Fudan University, Shanghai, 200032, China.
Yu ZhangShanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai, 201203, China.
Hua ZhuDepartment of Obstetrics and Gynaecology, BC Children's Hospital Research Institute, University of British Columbia, Vancouver, British Columbia, V5Z 4H4, Canada.
Zhao LiLaboratory of Reproductive Pharmacology, Shanghai Institute of Planned Parenthood Research; Key Lab. of Reproduction Regulation of NPFPC, SIPPR, IRD, Fudan University, Shanghai, 200032, China.
Jung-Chien ChengDepartment of Obstetrics and Gynaecology, BC Children's Hospital Research Institute, University of British Columbia, Vancouver, British Columbia, V5Z 4H4, Canada.ORCID http://orcid.org/0000-0002-5399-9327
Shuwu XieLaboratory of Reproductive Pharmacology, Shanghai Institute of Planned Parenthood Research; Key Lab. of Reproduction Regulation of NPFPC, SIPPR, IRD, Fudan University, Shanghai, 200032, China.ORCID http://orcid.org/0000-0001-5753-6824
Wenjie YangLaboratory of Reproductive Pharmacology, Shanghai Institute of Planned Parenthood Research; Key Lab. of Reproduction Regulation of NPFPC, SIPPR, IRD, Fudan University, Shanghai, 200032, China.
Ying LiShanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai, 201203, China.
Peter C K LeungDepartment of Obstetrics and Gynaecology, BC Children's Hospital Research Institute, University of British Columbia, Vancouver, British Columbia, V5Z 4H4, Canada. peter.leung@ubc.ca.ORCID http://orcid.org/0000-0003-3152-3800
Fudan University · CNUniversity of British Columbia · CAChinese Academy of Sciences · CN

Funding

CIHR 143317
6 · The paper itself

Abstract

In the present study, a novel dimer, SM1044, selected from a series of dihydroartemisinin (DHA) derivatives containing nitrogen atoms comprising simple aliphatic amine linkers, showed strong growth inhibition in six types of human endometrial cancer (EC) cells, with half maximal inhibitory concentration (IC

Indexed as

ArtemisininsEndometrial NeoplasmsNitrogenAnimalsFemaleHumansPC12 CellsPeroxynitrous AcidRatsArtemisininsartenimolNitrogenPeroxynitrous AcidSM1044

Identifiers

PMID31664127
PMCPMC6820742
OpenAlexW2982397273

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.