ArticleScientific reports2019
Polymer-Salt Aqueous Two-Phase System (ATPS) Micro-Droplets for Cell Encapsulation.
Article in Scientific reports, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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Who cites it
18 citing papers in PubMed.
- Aqueous Two-Phase Bioinks for Discrete Packing and Compartmentalization of 3D Bioprinted Cells.Advanced healthcare materials · 2026Article
- Multicompartment hydrogel microcapsules for creating spatially patterned cell co-cultures.Microsystems & nanoengineering · 2026Article
- Gelatin Methacrylate Macroporous Cell Scaffold Fabrication via One-Pot Aqueous Two-Phase Separation.Journal of biomedical materials research. Part B, Applied biomaterials · 2025Article
- Smart coacervate microdroplets: biomimetic design, material innovations, and emerging applications in biomacromolecule delivery.Bioactive materials · 2025Review
- High-throughput cultivation and isolation of environmental anaerobes using selectively permeable hydrogel capsules.ISME communications · 2025Article
- Advancements in Aqueous Two-Phase Systems for Enzyme Extraction, Purification, and Biotransformation.Molecules (Basel, Switzerland) · 2024Review
- Self-assembly of stabilized droplets from liquid-liquid phase separation for higher-order structures and functions.Communications chemistry · 2024Review
- Review
- Direct imaging of micrometer-thick interfaces in salt-salt aqueous biphasic systems.Proceedings of the National Academy of Sciences of the United States of America · 2023Article
- Biomolecular Liquid-Liquid Phase Separation for Biotechnology.Biotech (Basel (Switzerland)) · 2023Review
- Aqueous Two-Phase Interfacial Assembly of COF Membranes for Water Desalination.Nano-micro letters · 2022Article
- A novel method for double encapsulation of C-phycocyanin using aqueous two phase systems for extension of shelf life.Journal of food science and technology · 2021Article
- Connecting primitive phase separation to biotechnology, synthetic biology, and engineering.Journal of biosciences · 2021Review
- Aqueous Triple-Phase System in Microwell Array for Generating Uniform-Sized DNA Hydrogel Particles.Frontiers in genetics · 2021Article
- Enhanced single-cell encapsulation in microfluidic devices: From droplet generation to single-cell analysis.Biomicrofluidics · 2020Review
- Immobilization of FGF on Poly(xylitol dodecanedioic Acid) Polymer for Tissue Regeneration.Scientific reports · 2020Article
- A Droplet Microfluidic System to Fabricate Hybrid Capsules Enabling Stem Cell Organoid Engineering.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2020Article
- Patterning of Particles and Live Cells at Single Cell Resolution.Micromachines · 2020Article
Corrections and comments
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Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Biosample encapsulation is a critical step in a wide range of biomedical and bioengineering applications. Aqueous two-phase system (ATPS) droplets have been recently introduced and showed a great promise to the biological separation and encapsulation due to their excellent biocompatibility. This study shows for the first time the passive generation of salt-based ATPS microdroplets and their biocompatibility test. We used two ATPS including polymer/polymer (polyethylene glycol (PEG)/dextran (DEX)) and polymer/salt (PEG/Magnesium sulfate) for droplet generation in a flow-focusing geometry. Droplet morphologies and monodispersity in both systems are studied. The PEG/salt system showed an excellent capability of uniform droplet formation with a wide range of sizes (20-60 μm) which makes it a suitable candidate for encapsulation of biological samples. Therefore, we examined the potential application of the PEG/salt system for encapsulating human umbilical vein endothelial cells (HUVECs). A cell viability test was conducted on MgSO
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