ArticleScientific reports2019
NEMA Performance Evaluation of CareMiBrain dedicated brain PET and Comparison with the whole-body and dedicated brain PET systems.
Article in Scientific reports, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.
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Who cites it
28 citing papers in PubMed, 62 citations in OpenAlex.
- Performance evaluation of a dedicated brain PET scanner with octagonal detector arrangement using a modified NEMA NU2 2018 protocol.Medical physics · 2026Article
- First-in-Human Imaging Results of PHAROS: A Versatile High-Resolution TOF/DOI PET Scanner for Brain, Breast, and Extremity Imaging.Journal of nuclear medicine : official publication, Society of Nuclear Medicine · 2026Article
- Performance Evaluation of SmartBrain: A Wearable PET System for Human Brain Imaging.Journal of nuclear medicine : official publication, Society of Nuclear Medicine · 2026Article
- Beyond CT: Attenuation correction for stand-alone brain PET.Zeitschrift fur medizinische Physik · 2026Review
- Performance of detector modules designed for the NeuroSphere brain PET system.Medical physics · 2026Article
- Evaluation of a PET Insert for Trimodal Imaging: A Step Toward PET/MRI-Guided Focused Ultrasound.IEEE transactions on radiation and plasma medical sciences · 2026Article
- Review
- Impact of detector parameters and image resolution modeling on dedicated brain PET imaging.IEEE transactions on radiation and plasma medical sciences · 2025Article
- Design of a Mobile and Electromagnetic Emissions-Compliant Brain Positron Emission Tomography (PET) Scanner.Sensors (Basel, Switzerland) · 2025Article
- Multi-angle acquisition and 3D composite reconstruction for organ-targeted PET using planar detectors.Medical physics · 2025Article
- Quantitative Accuracy Assessment of the NeuroEXPLORER for Diverse Imaging Applications: Moving Beyond Standard Evaluations.Journal of nuclear medicine : official publication, Society of Nuclear Medicine · 2025Article
- PET detectors with depth-of-interaction and time-of-flight capabilities.Radiological physics and technology · 2024Review
- Performance Characteristics of the NeuroEXPLORER, a Next-Generation Human Brain PET/CT Imager.Journal of nuclear medicine : official publication, Society of Nuclear Medicine · 2024Article
- Dynamic Human Brain Imaging with a Portable PET Camera: Comparison to a Standard Scanner.Journal of nuclear medicine : official publication, Society of Nuclear Medicine · 2024Article
- New Horizons in Brain PET Instrumentation.PET clinics · 2024Review
- The quest for multifunctional and dedicated PET instrumentation with irregular geometries.Annals of nuclear medicine · 2024Review
- A conformal TOF-DOI Prism-PET prototype scanner for high-resolution quantitative neuroimaging.Medical physics · 2023Article
- Technical opportunities and challenges in developing total-body PET scanners for mice and rats.EJNMMI physics · 2023Review
- Evaluation of the performance of a high-resolution time-of-flight PET system dedicated to the head and breast according to NEMA NU 2-2012 standard.EJNMMI physics · 2022Article
- Performance evaluation of dedicated brain PET scanner with motion correction system.Annals of nuclear medicine · 2022Article
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Authors and funding
6 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
This article presents system performance studies of the CareMiBrain dedicated brain PET according to NEMA NU 2-2012 (for whole-body PETs) and NU 4-2008 (for preclinical PETs). This scanner is based on monolithic LYSO crystals coupled to silicon photomultipliers. The results obtained for both protocols are compared with current commercial whole body PETs and dedicated brain PETs found in the literature. Spatial resolution, sensitivity, NECR and scatter-fraction are characterized with NEMA standards, as well as an image quality study. A customized image quality phantom is proposed as NEMA phantoms do not fulfil the necessities of dedicated brain PETs. The full-width half maximum of the radial/tangential/axial spatial resolution of CareMiBrain reconstructed with FBP at 10 and 100 mm from the system center were, respectively, 1.87/1.68/1.39 mm and 1.86/1.91/1.40 mm (NU 2-2012) and 1.58/1.45/1.40 mm and 1.64/1.66/1.44 mm (NU 4-2008). Peak NECR was 49 kcps@287 MBq with a scatter fraction of 48% using NU 2-2012 phantom. The sensitivity was 13.82 cps/kBq at the center of the FOV (NU 2-2012) and 10% (NU 4-2008). Contrast recovery coefficients for customizing image quality phantom were 0.73/0.78/1.14/1.01 for the 4.5/6/9/12 mm diameter rods. The performance characteristics of CareMiBrain are at the top of the current technologies for PET systems. Dedicated brain PET systems significantly improve spatial resolution and sensitivity, but present worse results in count rate measurements and scatter-fraction tests. As for the comparison of preclinical and clinical standards, the results obtained for solid and liquid sources were similar.
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