ArticleScientific reports2019
Extreme sampling design in genetic association mapping of quantitative trait loci using balanced and unbalanced case-control samples.
Article in Scientific reports, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers, 1 of them a synthesis that pooled it.
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Who cites it
28 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Genome-wide association studies for canine hip dysplasia in single and multiple populations - implications and potential novel risk loci.BMC genomics · 2021Pooled it
- Charting the Phenotypic Landscape of FBN1 Variants in Marfan Syndrome With Ectopia Lentis Through Extreme Phenotype Sampling.Investigative ophthalmology & visual science · 2026Article
- Bayesian Genome-Wide Association Study of Feed Efficiency Traits in Pigs.Animals : an open access journal from MDPI · 2026Article
- Wild genes to the rescue: high-throughput genomics reveals the wild source of broomrape resistance in sunflower.Journal of experimental botany · 2026Article
- Genotype subtyping approach to identify unnoticed variants in diseases from GWAS data.BioData mining · 2026Article
- Mathematical bounds on rTheoretical population biology · 2025Article
- Clinical validation of an integrated risk assessment test incorporating genomic and non-genomic data for sporadic breast cancer in Colombia.Frontiers in genetics · 2025Article
- Mathematical bounds onbioRxiv : the preprint server for biology · 2024Article
- The effects of case/control ratio and sample size on genome-wide association studies: A simulation study.Veterinary medicine and science · 2024Article
- Extreme trait GWAS (Et-GWAS): Unraveling rare variants in the 3,000 rice genome.Life science alliance · 2024Article
- The genetic architecture of youth anxiety: a study protocol.BMC psychiatry · 2024Article
- Variants of IL6, IL10, FCN2, RNASE3, IL12B and IL17B loci are associated with Schistosoma mansoni worm burden in the Albert Nile region of Uganda.PLoS neglected tropical diseases · 2023Article
- Genome-Wide Association Study of Fiber Diameter in Alpacas.Animals : an open access journal from MDPI · 2023Article
- Genome-wide association and genomic prediction for a reproductive index summarizing fertility outcomes in U.S. Holsteins.G3 (Bethesda, Md.) · 2023Article
- Genomic prediction of growth in a commercially, recreationally, and culturally important marine resource, the Australian snapper (Chrysophrys auratus).G3 (Bethesda, Md.) · 2022Article
- The statistical power of genome-wide association studies for threshold traits with different frequencies of causal variants.Genetica · 2022Article
- Genetic susceptibility loci forFrontiers in immunology · 2022Article
- Quantitative Trait Loci Identification by Estimating the Genetic Model based on the Extremal Samples.Current genomics · 2021Review
- Fine dissection of limber pine resistance to Cronartium ribicola using targeted sequencing of the NLR family.BMC genomics · 2021Article
- Review
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Authors and funding
6 authors.
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Abstract
It is extremely expensive to conduct large sample size array- or sequencing based genome scale association studies. For a quantitative trait, an extreme case-control study design may improve the power and reduce the cost of variant calling. We investigated the performance of extreme study design when various proportions of samples are selected from the tails of phenotype distribution. Using simulations, we show that when risk genotypes become rare in the population and effect size is relatively small, it is beneficial to carry out an extreme sampling study. In particular, the number of selected cases and controls can even be unbalanced such that power is further increased, compared with a balanced selection. Our application to two data sets: methadone dose data and yearling weight data, demonstrated that similar results for full data analysis can be obtained using extreme sampling with only a fraction of the data. Using power analysis with simulated data and an experimental data application, we conclude that when full data is unavailable due to restricted budget, it is rewarding to employ an extreme sampling design in the sense that there can be immense cost reductions and qualitatively similar power as in the full data analysis.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.