Evidence map›Paper›PMID 31663906›Full record

Trial reportClinical and translational gastroenterology2019

Influence of Gastric Emptying and Gut Transit Testing on Clinical Management Decisions in Suspected Gastroparesis.

William L Hasler, Satish S C Rao, Richard W McCallum, Richard A Krause, Linda A Nguyen, Michael I Schulman, Allen A Lee, Baharak Moshiree, John M Wo, Henry P Parkman and 3 more

Open access · goldAbstract readClinical TrialMulticenter Study
In one paragraph

Trial report in Clinical and translational gastroenterology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
1.8field-weighted citation impact, top 15% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 24 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Article
  6. Review
  7. Review
  8. Article
  9. Baseline Predictors of Longitudinal Changes in Symptom Severity and Quality of Life in Patients With Suspected Gastroparesis.Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association · 2022
    Observational
  10. Article
  11. Review
  12. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 10 institutions in 1 country.

William L HaslerDivision of Gastroenterology, University of Michigan Health System, Ann Arbor, Michigan, USA.
Satish S C RaoDivision of Gastroenterology and Hepatology, Medical College of Georgia, Augusta, Georgia, USA.
Richard W McCallumSection of Gastroenterology, Texas Tech University, El Paso, Texas, USA.
Richard A KrauseClin Search, LLC, Chattanooga, Tennessee, USA.
Linda A NguyenDivision of Gastroenterology, Stanford University, Palo Alto, California, USA.
Michael I SchulmanFlorida Digestive Health Associates, Largo, Florida, USA.
Allen A LeeDivision of Gastroenterology, University of Michigan Health System, Ann Arbor, Michigan, USA.
Baharak MoshireeAtrium Health Gastroenterology and Hepatology, Carolinas HealthCare System Digestive Health-Morehead Medical Plaza, Charlotte, North Carolina, USA.
John M WoDivision of Gastroenterology and Hepatology, Indiana University, Indianapolis, Indiana, USA.
Henry P ParkmanSection of Gastroenterology, Temple University, Philadelphia, Pennsylvania, USA.
Irene SarosiekSection of Gastroenterology, Texas Tech University, El Paso, Texas, USA.
Gregory E WildingDepartment of Biostatistics, University of Buffalo, Buffalo, New York, USA.
Braden KuoDivision of Gastroenterology, Massachusetts General Hospital, Boston, Massachusetts, USA.
Texas Tech University · USUniversity of Michigan–Ann Arbor · USAugusta University · USCarolinas Healthcare System · USIndiana University – Purdue University Indianapolis · USMassachusetts General Hospital · USSearch · USStanford University · USTemple University · USUniversity at Buffalo, State University of New York · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

introductionGastric emptying scintigraphy (GES) or wireless motility capsules (WMCs) can evaluate upper gastrointestinal symptoms in suspected gastroparesis; WMC tests can also investigate lower gut symptoms. We aimed to determine whether these tests impact treatment plans and needs for additional diagnostic evaluation.

methodsIn a prospective, multicenter study, 150 patients with gastroparesis symptoms simultaneously underwent GES and WMC testing. Based on these results, investigators devised management plans to recommend changes in medications, diet, and surgical therapies and order additional diagnostic tests.

resultsTreatment changes were recommended more often based on the WMC vs GES results (68% vs 48%) (P < 0.0001). Ordering of additional test(s) was eliminated more often with WMC vs GES (71% vs 31%) (P < 0.0001). Prokinetics (P = 0.0007) and laxatives (P < 0.0001) were recommended more often based on the WMC vs GES results. Recommendations for prokinetics and gastroparesis diets were higher and neuromodulators lower in subjects with delayed emptying on both tests (all P ≤ 0.0006). Laxatives and additional motility tests were ordered more frequently for delayed compared with normal WMC colonic transit (P ≤ 0.02). Multiple motility tests were ordered more often on the basis of GES vs WMC findings (P ≤ 0.004). Antidumping diets and transit slowing medications were more commonly recommended for rapid WMC gastric emptying (P ≤ 0.03). DISCUSSION: WMC transit results promote medication changes and eliminate additional diagnostic testing more often than GES because of greater detection of delayed gastric emptying and profiling the entire gastrointestinal tract in patients with gastroparesis symptoms. TRANSLATIONAL IMPACT: Gastric scintigraphy and WMCs have differential impact on management decisions in suspected gastroparesis.

Indexed as

AdolescentAdultAgedAged, 80 and overCapsule EndoscopyClinical Decision-MakingFemaleGastric EmptyingGastrointestinal TransitGastroparesisHumansMaleMiddle AgedProspective StudiesRadionuclide ImagingStomach

Identifiers

PMID31663906
PMCPMC6919448
OpenAlexW2982362527

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.