ArticleeLife2019
Lactate-mediated epigenetic reprogramming regulates formation of human pancreatic cancer-associated fibroblasts.
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Article in eLife, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 116 papers.
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116citing papers in PubMed
6.3field-weighted citation impact, top 3% of its field
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Who cites it
116 citing papers in PubMed, 163 citations in OpenAlex.
- Gut Microbiota-Derived Extracellular Vesicles in Cancer: Friends or Foes?Probiotics and antimicrobial proteins · 2026Review
- Metabolic reprogramming in cancer-associated fibroblasts: orchestrating the tumor immune microenvironment and response to immune checkpoint blockade.Experimental hematology & oncology · 2026Review
- The tumor microenvironment in pancreatic cancer: from composition to therapeutic targeting.Biochemical Society transactions · 2026Review
- Review
- Stem cells as an essential mediator of the exercise-tumorigenesis link.Nature reviews. Cancer · 2026Review
- Targeting Lactate and Lactylation in Cancer Metabolism and Immunotherapy.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Review
- PKM2-Mediated Glycolytic Reprogramming in Thyroid Cancer: Mechanistic Insights and Therapeutic Potential.Molecules (Basel, Switzerland) · 2026Review
- Immune cross talk and therapeutic advances in lactate metabolism in the tumor microenvironment (Review).Experimental and therapeutic medicine · 2026Review
- Identification of Key Genes Regulated by Lactylation Modification and Associated with Tumor Immune Microenvironment in Breast Cancer.Current issues in molecular biology · 2026Article
- Microbiota in pancreatic ductal adenocarcinoma progression and therapy: The hidden players.Chinese medical journal · 2026Review
- Mechanistic insights into pancreatic cancer progression from circadian rhythm disruption and gut microbiota dysbiosis (Review).International journal of molecular medicine · 2026Review
- Ability of lactylation-related genes to stratify patients with ovarian cancer and predict immunotherapy response.Translational cancer research · 2026Article
- Epigenetic modulation to overcome immune suppression in pancreatic cancer.Clinical epigenetics · 2026Review
- Lactate, a Spearhead of Cancer Aggressiveness: Metabolic Reprogramming, Immune Suppression, and Metastatic Progression.Medical principles and practice : international journal of the Kuwait University, Health Science Centre · 2026Review
- The Heterogeneity and Function of Stromal Cells in the Tumor Microenvironment.Research (Washington, D.C.) · 2026Review
- Tumor-stromal metabolic crosstalk in pancreatic cancer.Trends in cell biology · 2025Review
- Lactate as a metabolic-epigenetic signal linking high-intensity interval training (HIIT) to miRNA-Centered remodeling of the skeletal muscle methylome and transcriptome.Redox biology · 2025Article
- The tumour microenvironment in pancreatic cancer - new clinical challenges, but more opportunities.Nature reviews. Clinical oncology · 2025Review
- FBLN2 promoter hypermethylation: a negative prognostic biomarker and anti-PD-1 response predictor in clear cell renal cell carcinoma via high-throughput CpG Island screening.Clinical epigenetics · 2025Article
- Significance of Epigenetic Alteration in Cancer-Associated Fibroblasts on the Development of Carcinoma.International journal of molecular sciences · 2025Review
56 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
33 authors at 8 institutions in 1 country.
Tushar D BhagatAlbert Einstein College of Medicine, Montefiore Medical Center, New York, United States.ORCID 0000-0002-4527-5505
Dagny Von AhrensAlbert Einstein College of Medicine, Montefiore Medical Center, New York, United States.
Meelad DawlatyAlbert Einstein College of Medicine, Montefiore Medical Center, New York, United States.
Yiyu ZouAlbert Einstein College of Medicine, Montefiore Medical Center, New York, United States.
Joelle BaddourDepartment of Biomedical Engineering, University of Michigan, Ann Arbor, United States.
Abhinav AchrejaDepartment of Biomedical Engineering, University of Michigan, Ann Arbor, United States.
Hongyun ZhaoDepartment of Biomedical Engineering, University of Michigan, Ann Arbor, United States.
Lifeng YangDepartment of Biomedical Engineering, University of Michigan, Ann Arbor, United States.
Brijesh PatelRutgers University, New Brunswick, United States.
Changsoo KwakDepartment of Pathology, Sheikh Ahmed Pancreatic Cancer Research Center, UT MD Anderson Cancer Center, Houston, United States.
Gaurav S ChoudharyAlbert Einstein College of Medicine, Montefiore Medical Center, New York, United States.
Shanisha Gordon-MitchellAlbert Einstein College of Medicine, Montefiore Medical Center, New York, United States.
Srinivas AluriAlbert Einstein College of Medicine, Montefiore Medical Center, New York, United States.
Sanchari BhattacharyyaAlbert Einstein College of Medicine, Montefiore Medical Center, New York, United States.
Srabani SahuAlbert Einstein College of Medicine, Montefiore Medical Center, New York, United States.
Prafulla BhagatAlbert Einstein College of Medicine, Montefiore Medical Center, New York, United States.
Yiting YuAlbert Einstein College of Medicine, Montefiore Medical Center, New York, United States.
Matthias BartensteinAlbert Einstein College of Medicine, Montefiore Medical Center, New York, United States.ORCID 0000-0002-0908-770X
Orsi GiriczAlbert Einstein College of Medicine, Montefiore Medical Center, New York, United States.
Masako SuzukiAlbert Einstein College of Medicine, Montefiore Medical Center, New York, United States.
Davendra SohalDepartment of Medicine, Cleveland Clinic, Cleveland, United States.
Sonal GuptaDepartment of Pathology, Sheikh Ahmed Pancreatic Cancer Research Center, UT MD Anderson Cancer Center, Houston, United States.
Paola A GuerreroDepartment of Pathology, Sheikh Ahmed Pancreatic Cancer Research Center, UT MD Anderson Cancer Center, Houston, United States.
Surinder BatraUniversity of Nebraska Medical Center, Omaha, United States.
Michael GogginsJohns Hopkins, Baltimore, United States.
Ulrich SteidlAlbert Einstein College of Medicine, Montefiore Medical Center, New York, United States.
John GreallyAlbert Einstein College of Medicine, Montefiore Medical Center, New York, United States.ORCID 0000-0001-6069-7960
Beamon AgarwalGenomeRxUs LLC, Secane, United States.
Kith PradhanAlbert Einstein College of Medicine, Montefiore Medical Center, New York, United States.
Debabrata BanerjeeRutgers University, New Brunswick, United States.
Deepak NagrathBiointerfaces Institute, University of Michigan, Ann Arbor, United States.ORCID 0000-0002-8999-2282
Anirban MaitraDepartment of Pathology, Sheikh Ahmed Pancreatic Cancer Research Center, UT MD Anderson Cancer Center, Houston, United States.
Amit VermaAlbert Einstein College of Medicine, Montefiore Medical Center, New York, United States.ORCID 0000-0001-7592-7693
Albert Einstein College of Medicine · USUniversity of Michigan · USThe University of Texas MD Anderson Cancer Center · USRutgers, The State University of New Jersey · USCaerus Molecular Diagnostics (United States) · USCleveland Clinic · USJohns Hopkins University · USUniversity of Nebraska Medical Center · US
Funding
The RAS and P13K Pathways in Pancreatic AdenocarcinomaP01CA117969 · NCI · UNIVERSITY OF TX MD ANDERSON CAN CTR · PI DEPINHO, RONALD ANTHONY · 2006 to 2025
$41.7MTranslational Research Enhancement CoreP30DK089502 · NIDDK · JOHNS HOPKINS UNIVERSITY · PI ZACHOS, NICHOLAS CONSTANTINE · 2011 to 2020
$12.0MPancreatic Ductal Adenocarcinoma Translational Resource Center (PATReC)U24CA224020 · NCI · UNIVERSITY OF TX MD ANDERSON CAN CTR · PI MAITRA, ANIRBAN, SEN, SUBRATA · 2017 to 2021
$2.8MTraining of Surgeons for Studies of the Tumor MicroenvironmentT32CA200561 · NCI · ALBERT EINSTEIN COLLEGE OF MEDICINE, INC · PI MCAULIFFE, JOHN · 2015 to 2024
$2.7MTranslational Applications in an Animal Model of Pancreatic Cystic Neoplasm and CancerR01CA218004 · NCI · UNIVERSITY OF TX MD ANDERSON CAN CTR · PI MAITRA, ANIRBAN · 2018 to 2021
$2.4MTargeting Stromal Influences on Glutamine Addiction in Ovarian CancerR01CA227622 · NCI · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI MOK, SAMUEL C, NAGRATH, DEEPAK · 2018 to 2022
$2.3MWnt/?-catenin Signaling in Pancreatic OncogenesisR01CA220236 · NCI · UNIVERSITY OF TX MD ANDERSON CAN CTR · PI MAITRA, ANIRBAN · 2017 to 2023
$1.8MIdentification of USP13 as a therapeutic target for ovarian cancerR01CA222251 · NCI · INDIANA UNIVERSITY INDIANAPOLIS · PI LU, XIONGBIN, NAGRATH, DEEPAK · 2018 to 2022
$1.8MUncovering Role of Exosomes in Regulating Pancreatic Cancer Cell MetabolismR01CA204969 · NCI · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI NAGRATH, DEEPAK · 2017 to 2021
$1.7MNCI NIH HHS P01 CA117969NCI NIH HHS P01CA117969NCI NIH HHS R01 CA204969NCI NIH HHS R01CA204969NCI NIH HHS R01 CA218004NCI NIH HHS R01CA218004NCI NIH HHS R01 CA220236NCI NIH HHS R01CA220236NCI NIH HHS R01 CA222251NCI NIH HHS R01CA222251NCI NIH HHS R01 CA227622NCI NIH HHS R01CA227622NCI NIH HHS T32 CA200561NCI NIH HHS U24 CA224020NCI NIH HHS U24CA224020NIDDK NIH HHS P30 DK089502
Abstract
Even though pancreatic ductal adenocarcinoma (PDAC) is associated with fibrotic stroma, the molecular pathways regulating the formation of cancer associated fibroblasts (CAFs) are not well elucidated. An epigenomic analysis of patient-derived and de-novo generated CAFs demonstrated widespread loss of cytosine methylation that was associated with overexpression of various inflammatory transcripts including
Indexed as
5-MethylcytosineAnimalsCancer-Associated FibroblastsCarcinoma, Pancreatic DuctalCell Line, TumorCell ProliferationCell Transformation, NeoplasticCellular ReprogrammingDNA MethylationEpigenesis, GeneticHumansKetoglutaric AcidsLactic AcidMesenchymal Stem CellsMiceNeoplasm Invasiveness5-hydroxymethylcytosine5-MethylcytosineKetoglutaric AcidsLactic AcidReceptors, CXCR4cancer biologymethylationmousepancreasstroma
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.