Evidence map›Paper›PMID 31663850›Full record

ArticleeLife2019

Kv2.1 mediates spatial and functional coupling of L-type calcium channels and ryanodine receptors in mammalian neurons.

Nicholas C Vierra, Michael Kirmiz, Deborah van der List, L Fernando Santana, James S Trimmer

Abstract read
In one paragraph

Article in eLife, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 69 papers.

0numbers the graph read from it
0cells of the map it votes in
69citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

69 citing papers in PubMed.

  1. CaThe Journal of physiology · 2026
    Article
  2. Review
  3. Review
  4. Article
  5. Nanoscale CabioRxiv : the preprint server for biology · 2026
    Article
  6. Review
  7. Nanoscale architecture and dynamics of CaJournal of molecular and cellular cardiology plus · 2025
    Article
  8. Ion channels and actin: A tale of two friends.Histology and histopathology · 2025
    Review
  9. Article
  10. Article
  11. Review
  12. Article
  13. Article
  14. Article
  15. The Electrically Silent Kv5.1 Subunit Forms Heteromeric Kv2 Channels in Cortical Neurons and Confers Distinct Functional Properties.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2025
    Article
  16. Article
  17. Glucocorticoids Rapidly Modulate CaThe Journal of neuroscience : the official journal of the Society for Neuroscience · 2024
    Article
  18. The Endoplasmic Reticulum and Its Contacts: Emerging Roles in Axon Development, Neurotransmission, and Degeneration.The Neuroscientist : a review journal bringing neurobiology, neurology and psychiatry · 2024
    Review
  19. Review
  20. Article

9 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Nicholas C VierraDepartment of Physiology and Membrane Biology, School of Medicine, University of California, Davis, Davis, United States.ORCID 0000-0001-7269-5399
Michael KirmizDepartment of Neurobiology, Physiology, and Behavior, University of California, Davis, Davis, United States.
Deborah van der ListDepartment of Physiology and Membrane Biology, School of Medicine, University of California, Davis, Davis, United States.
L Fernando SantanaDepartment of Physiology and Membrane Biology, School of Medicine, University of California, Davis, Davis, United States.ORCID 0000-0002-4297-8029
James S TrimmerDepartment of Physiology and Membrane Biology, School of Medicine, University of California, Davis, Davis, United States.ORCID 0000-0002-6117-3912

Funding

UC Davis MCB T32 Administrative Supplement to Recognize Excellence in Diversity, Equity, Inclusion, and Accessibility (DEIA) MentorshipT32GM007377 · NIGMS · UNIVERSITY OF CALIFORNIA DAVIS · PI CHEDIN, FREDERIC LOUIS · 1985 to 2023
$9.9M
Genetically Encoded Localization Modules for Targeting Activity Probes to Specific Subcellular Sites in Brain NeuronsU01NS099714 · NINDS · UNIVERSITY OF CALIFORNIA AT DAVIS · PI TRIMMER, JAMES S · 2016 to 2018
$3.4M
Tuning L-Type Ca Channel Activity in Arterial Smooth Muscle by Kv Channel-Mediated ClusteringR01HL144071 · NHLBI · UNIVERSITY OF CALIFORNIA AT DAVIS · PI SANTANA, LUIS F, TRIMMER, JAMES S · 2018 to 2021
$2.0M
Defining the Proteomic Composition of ER:Plasma Membrane Junctions in Brain NeuronsR21NS101648 · NINDS · UNIVERSITY OF CALIFORNIA AT DAVIS · PI TRIMMER, JAMES S · 2018 to 2019
$348k
Dynamic modulation of ionic and lipid signaling by neuronal Kv2 channelsF32NS108519 · NINDS · UNIVERSITY OF CALIFORNIA AT DAVIS · PI VIERRA, NICHOLAS CATIN · 2018 to 2020
$168k
NHLBI NIH HHS R01 HL144071NIGMS NIH HHS T32 GM007377NINDS NIH HHS F32 NS108519NINDS NIH HHS R21 NS101648NINDS NIH HHS U01 NS099714
6 · The paper itself

Abstract

The voltage-gated K

Indexed as

AnimalsCalcium Channels, L-TypeCells, CulturedHumansMice, Inbred C57BLNeuronsRats, Sprague-DawleyRyanodine Receptor Calcium Release ChannelShab Potassium ChannelsCalcium Channels, L-TypeRyanodine Receptor Calcium Release ChannelShab Potassium Channelscalcium signalingion channelmembrane contact sitesmolecular biophysicsmouseneuroscienceratstructural biology

Identifiers

PMID31663850
PMCPMC6839919

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.