Trial reportAmerican journal of physiology. Regulatory, integrative and comparative physiology2019
Impact of menopausal hormone formulations on pituitary-ovarian regulatory feedback.
Trial report in American journal of physiology. Regulatory, integrative and comparative physiology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
18 citing papers in PubMed, 25 citations in OpenAlex.
- Injectable contraceptives differentially affect the hypothalamic-pituitary-gonadal axis and amenorrhea incidence†.Biology of reproduction · 2026Trial
- Efficacy and Safety of Hormone Replacement Combined With Escitalopram in the Treatment of Chronic Insomnia in Perimenopausal Women: A Randomized Controlled Trial.CNS neuroscience & therapeutics · 2025Trial
- Associations between pituitary-ovarian hormones and cognition in recently menopausal women independent of type of hormone therapy.Maturitas · 2023Trial
- Cardiometabolic measures and cognition in early menopause - Analysis of baseline data from a randomized controlled trial.Maturitas · 2022Trial
- Moderate Consumption of Beer (with and without Ethanol) and Menopausal Symptoms: Results from a Parallel Clinical Trial in Postmenopausal Women.Nutrients · 2021Trial
- Lessons from KEEPS: the Kronos Early Estrogen Prevention Study.Climacteric : the journal of the International Menopause Society · 2021Trial
- Is Follicle-Stimulating Hormone (FSH) Misnamed? Rethinking Its Role in Menopause as a Systemic Regulator of Bone, Brain, Metabolism, and Aging.Journal of clinical medicine · 2026Review
- Seawater pearl hydrolysate alleviates perimenopausal syndrome by modulating hypothalamic and uterine ERα/MAPK/CREB signaling in ovariectomized rats.Frontiers in pharmacology · 2026Article
- Hormone Replacement Therapy and Cardiovascular Health in Postmenopausal Women.International journal of molecular sciences · 2025Review
- Association of Hormonal Exposures With Grip Strength in Women >45 Years: Data From the CONSTANCES Cohort Study.Journal of the Endocrine Society · 2024Article
- Article
- Estradiol enhanced neuronal plasticity and ameliorated astrogliosis in human iPSC-derived neural models.Regenerative therapy · 2024Article
- Whole-Body Vibration Exercise Improves the Functionality in Postmenopausal Women: A Systematic Review.Iranian journal of public health · 2023Review
- Extracellular matrix-derived scaffolds in constructing artificial ovaries for ovarian failure: a systematic methodological review.Human reproduction open · 2023Review
- Associations of reproductive factors with postmenopausal follicle stimulating hormone.Women's midlife health · 2022Article
- The Anti-Inflammatory and Uric Acid Lowering Effects of Si-Miao-San on Gout.Frontiers in immunology · 2021Article
- Characterizing the effects of tonic 17β-estradiol administration on spatial learning and memory in the follicle-deplete middle-aged female rat.Hormones and behavior · 2020Article
- Associations of pituitary-ovarian hormones and white matter hyperintensities in recently menopausal women using hormone therapy.Menopause (New York, N.Y.) · 2020Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
15 authors at 12 institutions in 1 country.
Funding
Abstract
Changes in pituitary-ovarian hormones across the menopausal transition have multiple physiological consequences. However, little is known about how the major types of postmenopausal hormone therapy (HT) affect pituitary-ovarian hormonal relationships. This study evaluated these relationships in recently menopausal women (52.45 ± 2.49 yr of age) in the Kronos Early Estrogen Prevention Study (KEEPS) who were compliant to randomized, double-blinded treatment with oral conjugated equine estrogen (o-CEE;
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.