Single-nucleotide polymorphisms in the coding region of a disintegrin and metalloproteinase with thrombospondin motifs 4 and hepatocellular carcinoma: A retrospective case-control study.
Xing-Zhizi Wang, Wei-Zhong Tang, Qun-Ying Su, Jin-Guang Yao, Xiao-Ying Huang, Qin-Qin Long, Xue-Min Wu, Qiang Xia, Xi-Dai Long
Article in Cancer medicine, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact, top 82% of its field
1 · What the graph read from it
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
2 · The registry
The trial behind it
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3 · Its place in the literature
Who cites it
2 citing papers in PubMed, 2 citations in OpenAlex.
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5 · Who and what money
Authors and funding
9 authors at 3 institutions in 1 country.
Xing-Zhizi WangDepartment of Pathology, The Affiliated Hospital of Youjiang Medical University for Nationalities, Baise, P.R. China.
Wei-Zhong TangDepartment of Gastrointestinal Surgery, The Affiliated Tumor Hospital, Guangxi Medical University, Nanning, P.R. China.
Qun-Ying SuDepartment of Pathology, The Affiliated Hospital of Youjiang Medical University for Nationalities, Baise, P.R. China.
Jin-Guang YaoDepartment of Pathology, The Affiliated Hospital of Youjiang Medical University for Nationalities, Baise, P.R. China.
Xiao-Ying HuangDepartment of Pathology, The Affiliated Hospital of Youjiang Medical University for Nationalities, Baise, P.R. China.
Qin-Qin LongDepartment of Pathology, The Affiliated Hospital of Youjiang Medical University for Nationalities, Baise, P.R. China.
Xue-Min WuDepartment of Pathology, The Affiliated Hospital of Youjiang Medical University for Nationalities, Baise, P.R. China.
Qiang XiaDepartment of Liver Surgery, School of Medicine, Ren Ji Hospital, Shanghai Jiao Tong University, Shanghai, P.R. China.
Xi-Dai LongDepartment of Pathology, The Affiliated Hospital of Youjiang Medical University for Nationalities, Baise, P.R. China.ORCID 0000-0003-0960-0689
Affiliated Hospital of Youjiang Medical University for Nationalities · CNShanghai Jiao Tong University · CNTumor Hospital of Guangxi Medical University · CN
Funding
'12th Five' Planning Program of Guangxi Education Science 2015C397Guangxi Clinic Research Center of Hepatobiliary Diseases AD17129025Innovation Program of Guangxi Health Department Z2013781Innovation Program of Guangxi Municipal Education Department 201204LX324Innovation Program of Guangxi Municipal Education Department 201204LX674Innovative Program of Guangxi Graduate Education JGY2015139Molecular Immunity Study Room Involving in Acute & Severe Diseases in Guangxi Colleges and Universities kfkt20160062Molecular Immunity Study Room Involving in Acute & Severe Diseases in Guangxi Colleges and Universities kfkt20160063National Natural Science Foundation of China 81372639National Natural Science Foundation of China 81460423National Natural Science Foundation of China 81472243National Natural Science Foundation of China 81572353National Natural Science Foundation of China 81660495National Natural Science Foundation of China 81760502National Natural Science Foundation of China 81860489Natural Science Foundation of Guangxi 2013GXNSFAA019251Natural Science Foundation of Guangxi 2014GXNSFAA118144Natural Science Foundation of Guangxi 2014GXNSFDA118021Natural Science Foundation of Guangxi 2015GXNSFAA139223Natural Science Foundation of Guangxi 2016GXNSFDA380003Natural Science Foundation of Guangxi 2017GXNSFAA198002Natural Science Foundation of Guangxi 2017GXNSFGA198002Natural Science Foundation of Guangxi 2018GXNSFAA281043Research Program of Guangxi Specially-invited Expert 2017-6thResearch Program of Guangxi "Zhouyue Scholar" 2017-38
6 · The paper itself
Abstract
Previous studies have shown that single-nucleotide polymorphisms (SNPs) of a disintegrin and metalloproteinase with thrombospondin type 1 motif 4 (ADAMTS4) may involve in the pathogenesis of some diseases. However, it is not clear whether they are associated with hepatocellular carcinoma (HCC). A hospital-based case-control study, including 862 cases with HCC and 1120 controls, was conducted to assess the effects of 258 SNPs in the coding regions of ADAMTS4 on HCC risk and prognosis. We found that six SNPs in ADAMTS4 were differential distribution between cases and controls via the primary screening analyses; however, only rs538321148 and rs1014509103 polymorphisms were further identified to modify the risk of HCC (odds ratio: 2.73 and 2.95; 95% confidence interval, 2.28-3.29 and 2.43-3.58; P-value, 5.73 × 10
Indexed as
Genetic Predisposition to DiseasePolymorphism, Single NucleotideADAMTS4 ProteinAllelesCarcinoma, HepatocellularCase-Control StudiesDisintegrinsFemaleGene Expression Regulation, NeoplasticGenotypeHumansKaplan-Meier EstimateLiver NeoplasmsOdds RatioPrognosisADAMTS4 ProteinADAMTS4 protein, humanDisintegrinsADAMTS4HCCprognosisriskSNPs
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.
Single-nucleotide polymorphisms in the coding region of a disintegrin and metalloproteinase with thrombospondin motifs 4 and hepatocellular carcinoma: A retrospective case-control study. · full record | OpenQuestion