Evidence map›Paper›PMID 31663690›Full record

Trial reportCancer medicine2019

Effects of serum from breast cancer surgery patients receiving perioperative dexmedetomidine on breast cancer cell malignancy: A prospective randomized controlled trial.

Yan Liu, Jiaxin Sun, Tong Wu, Xiaoying Lu, Yueyao Du, Hongwei Duan, Weifeng Yu, Diansan Su, Jinsong Lu, Jie Tian

Registry-linked trialOpen access · goldAbstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Cancer medicine, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05742438 (Effect of Dexmedetomidine Infusion, Lidocaine Infusion, and Intrathecal Morphine Injection on Biomarker for Perioperative Stress and Immune Response, and Cancer Progression and Metastasis in Colorectal Cancer Surgery), which is not on this map. Cited by 23 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
23citing papers in PubMed, 2 pooled it
1.8field-weighted citation impact, top 15% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT05742438 nacompletednot on this mapstarted 2023, after this paper: background citation

Effect of Dexmedetomidine Infusion, Lidocaine Infusion, and Intrathecal Morphine Injection on Biomarker for Perioperative Stress and Immune Response, and Cancer Progression and Metastasis in Colorectal Cancer Surgery

TypeinterventionalSponsorSamsung Medical CenterRan2023 to 2023Enrolled114ConditionsColorectal Cancer, Anesthesia, Cancer Metastatic, InflammationArmsLidocaine IV, Dexmedetomidine IV, intrathecal morphine
3 · Its place in the literature

Who cites it

23 citing papers in PubMed, 2 syntheses or guidelines pooled it, 29 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Trial
  4. Key role of the autonomic nervous system in breast cancer (Review).Experimental and therapeutic medicine · 2026
    Review
  5. Article
  6. Cancer and neurotransmitter receptors.Chinese medical journal · 2025
    Review
  7. Review
  8. Article
  9. Article
  10. Review
  11. Article
  12. Article
  13. Anesthesia and cancer recurrence: a narrative review.Anesthesia and pain medicine · 2024
    Review
  14. Review
  15. Article
  16. Review
  17. Article
  18. Review
  19. Article
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 2 institutions in 1 country.

Yan LiuDepartment of Anesthesiology, Renji Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.ORCID 0000-0002-9361-5017
Jiaxin SunDepartment of Anesthesiology, Renji Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
Tong WuDepartment of Anesthesiology, Renji Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
Xiaoying LuDepartment of Anesthesiology, Shanghai Pudong Hospital, Fudan University Pudong Medical Center, Shanghai, China.
Yueyao DuDepartment of Breast, Renji Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
Hongwei DuanDepartment of Anesthesiology, Shanghai Pudong Hospital, Fudan University Pudong Medical Center, Shanghai, China.
Weifeng YuDepartment of Anesthesiology, Renji Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
Diansan SuDepartment of Anesthesiology, Renji Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.ORCID 0000-0001-9755-1025
Jinsong LuDepartment of Breast, Renji Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.ORCID 0000-0003-3147-0702
Jie TianDepartment of Anesthesiology, Renji Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.ORCID 0000-0001-9642-2440
Shanghai Jiao Tong University · CNFudan University · CN

Funding

Renji Hospital Innovation Cultivating Research Funding PYMDT-006Shanghai Municipal Commission of Health and Family Planning Funding for Key Developing Disciplines 2015ZB0101Shanghai Pudong New Area Municipal Commission of Health and Family Planning Funding PW2016D-4
6 · The paper itself

Abstract

Adrenergic receptors (ARs) have gained attention for their involvement in breast cancer (BC) progression. Dexmedetomidine, a selective α

Indexed as

Perioperative PeriodAdrenergic alpha-2 Receptor AgonistsAdultAnalgesics, Non-NarcoticBiomarkers, TumorBreast NeoplasmsCell Line, TumorCell MovementCell ProliferationCombined Modality TherapyDexmedetomidineFemaleHumansMiddle AgedNeoplasm StagingAdrenergic alpha-2 Receptor AgonistsAnalgesics, Non-NarcoticBiomarkers, TumorDexmedetomidinebreast cancercell malignancydexmedetomidinegeneral anesthesia

Identifiers

PMID31663690
PMCPMC6912063
OpenAlexW2982632454

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.