ArticleAnnals of clinical and translational neurology2019
Cardiovascular factors are related to dopamine integrity and cognition in aging.
Article in Annals of clinical and translational neurology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
What it found
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Who cites it
13 citing papers in PubMed, 22 citations in OpenAlex.
- Fronto-striatal dopamine D2 receptor availability is associated with cognitive variability in older individuals with low dopamine integrity.Scientific reports · 2021Trial
- Article
- Associations between inflammation and striatal dopamine D2-receptor availability in aging.Journal of neuroinflammation · 2025Article
- White matter lesion load determines exercise-induced dopaminergic plasticity and working memory gains in aging.Translational psychiatry · 2023Article
- Cerebrovascular integrity affects gradients of aging-related dopamine D1 differences in the striatum.Aging brain · 2023Article
- Dopamine D1-signaling modulates maintenance of functional network segregation in aging.Aging brain · 2023Article
- Longitudinal stability in working memory and frontal activity in relation to general brain maintenance.Scientific reports · 2022Article
- Article
- Dopamine D2/3-receptor availability and its association with autonomous motivation to exercise in older adults: An exploratory [Frontiers in human neuroscience · 2022Article
- Cerebral arterial pulsatility is linked to hippocampal microvascular function and episodic memory in healthy older adults.Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism · 2021Article
- Multimodal Image Analysis of Apparent Brain Age Identifies Physical Fitness as Predictor of Brain Maintenance.Cerebral cortex (New York, N.Y. : 1991) · 2021Article
- The Longitudinal Association Between Cardiovascular Risk and Cognitive Function in Middle-Aged and Older Adults in China: A Nationally Representative Cohort Study.Frontiers in cardiovascular medicine · 2020Article
- Five-year associations among dopamine D2-like receptor loss, cognitive decline, education, and self-reported leisure activities in healthy older adults.Imaging neuroscience (Cambridge, Mass.)Article
Corrections and comments
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Authors and funding
17 authors at 3 institutions in 3 countries.
Funding
Abstract
objectiveThe aging brain undergoes several changes, including reduced vascular, structural, and dopamine (DA) system integrity. Such brain changes have been associated with age-related cognitive deficits. However, their relative importance, interrelations, and links to risk factors remain elusive.
methodsThe present work used magnetic resonance imaging and positron emission tomography with
resultsCovariance was found among several brain indicators, where top predictors of cognitive performance included caudate and hippocampal integrity (D2DR availability and volumes), and cortical blood flow and regional volumes. White-matter lesion burden was negatively correlated with caudate DA D2-receptor availability and white-matter microstructure. Compared to individuals with smaller lesions, individuals with confluent lesions (exceeding 20 mm in diameter) had reductions in cortical and hippocampal perfusion, striatal and hippocampal D2-receptor availability, white-matter microstructure, and reduced performance on tests of episodic memory, sequence learning, and processing speed. Higher cardiovascular risk as assessed by treatment for hypertension, systolic blood pressure, overweight, and smoking was associated with lower frontal cortical perfusion, lower putaminal D2DR availability, smaller grey-matter volumes, a larger number of white-matter lesions, and lower episodic memory performance.
interpretationTaken together, these findings suggest that reduced cardiovascular health is associated with poorer status for brain variables that are central to age-sensitive cognitive functions, with emphasis on DA integrity.
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