ArticleJournal of veterinary internal medicine2019
Estimation of glomerular filtration rate by plasma clearance of iohexol in healthy horses of various ages.
Article in Journal of veterinary internal medicine, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 3 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
3 citing papers in PubMed, 5 citations in OpenAlex.
- Advanced Strategies of Drug Delivery via Oral, Topical, and Parenteral Administration Routes: Where Do Equine Medications Stand?Pharmaceutics · 2023Review
- Population Pharmacokinetic Model of Iohexol in Dogs to Estimate Glomerular Filtration Rate and Optimize Sampling Time.Frontiers in pharmacology · 2021Article
- Estimation of glomerular filtration rate by plasma clearance of iohexol in healthy horses of various ages.Journal of veterinary internal medicine · 2019Article
Corrections and comments
- Erratum issued
Authors and funding
5 authors at 2 institutions in 2 countries.
Funding
Abstract
backgroundPlasma clearance of iohexol is a reliable method to assess the glomerular filtration rate (GFR). The relationship between aging and GFR in horses is unclear. HYPOTHESIS/
objectivesTo compare GFR estimated by iohexol clearance in horses of different ages. ANIMALS: Twenty-one clinically healthy horses were enrolled.
methodsProspective study. Groups: (A) composed by 8 young horses (≤14 years old) with serum creatinine <1.5 mg/dL, (B) by 7 aged horses (≥20 years old) with serum creatinine <1.5 mg/dL, and (C) by 6 aged horses (≥20 years old) with serum creatinine ≥1.5 mg/dL. Iohexol was injected (75.5 mg/kg) through an IV catheter, and plasma samples were collected 5, 30, and 90 minutes later. Plasma clearance of iohexol was obtained by the high-performance liquid chromatography-ultraviolet method.
resultsThe GFR was 2.6, 2.1, and 1.45 mL/min/kg (median value) in Groups A, B, and C, respectively. Statistical analysis showed differences between Group A versus B and A versus C for urea, and A versus C for creatinine and GFR. CONCLUSIONS AND CLINICAL IMPORTANCE: Glomerular filtration rate was significantly reduced in aged horses with serum creatinine ≥1.5 mg/dL compared to young horses with creatinine <1.5 mg/dL; no differences were obtained between young and aged horses with creatinine <1.5 mg/dL. Glomerular filtration rate evaluation should be considered in aged horses even if the plasma creatinine values are normal.
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