Evidence map›Paper›PMID 31663297›Full record

SynthesisMolecular genetics & genomic medicine2019

Association of MTHFR C677T polymorphism and type 2 diabetes mellitus (T2DM) susceptibility.

Yanzi Meng, Xiaoling Liu, Kai Ma, Lili Zhang, Mao Lu, Minsu Zhao, Min-Xin Guan, Guijun Qin

Abstract readMeta-Analysis
PubMed Full text at PMC Publisher
In one paragraph

Synthesis in Molecular genetics & genomic medicine, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
21citing papers in PubMed, 3 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

21 citing papers in PubMed, 3 syntheses or guidelines pooled it.

  1. Cross-Study Meta-Analysis of Blood Transcriptomes in Type 2 Diabetes.International journal of molecular sciences · 2025
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Yanzi MengDepartment of Endocrinology and Metabolism, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan, China.
Xiaoling LiuEndocrinology Department, Affiliated Hospital of Guilin Medical University, Guilin, Guangxi, China.
Kai MaHematology Department, Jincheng People's Hospital, Jincheng, Shannxi, China.
Lili ZhangEndocrinology Department, Jincheng General Hospital, Jincheng Coal General Hospital, Jincheng, Shannxi, China.
Mao LuLaboratory Medicine Department, Jincheng General Hospital, Jincheng Coal General Hospital, Jincheng, Shannxi, China.
Minsu ZhaoEndocrinology Department, Jincheng People's Hospital, Jincheng, Shannxi, China.
Min-Xin GuanInstitute of Genetics, Zhejiang University, Hangzhou, Zhejiang, China.
Guijun QinDepartment of Endocrinology and Metabolism, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan, China.ORCID 0000-0002-0533-9981

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

introductionMethylenetetrahydrofolate reductase (MTHFR) is essential in mediating folate metabolism, and thus plays an important role in diabetes and diabetic complications. MTHFR C677T (rs1801133 C>T) polymorphism has been proposed to be linked with type 2 diabetes mellitus (T2DM) susceptibility. However, the conclusions are inconsistent. Therefore, we rechecked their linkage aiming to obtain a more reliable estimation by performing an updated meta-analysis.

methodsWe searched electronic databases PubMed, EMBASE, CNKI, and Wanfang to obtain studies updated to October 2019.

resultsAfter carefully screening, we finally incorporated 68 studies with 10,812 cases and 8,745 controls. The genotype frequency of C677T polymorphism was analyzed pooled to generate odds ratios (ORs) and 95% confidence intervals (CIs). Pooled results presented that MTHFR C677T polymorphism was significantly associated with T2DM under homozygous (OR = 1.64, 95% CI = 1.39-1.94), heterozygous (OR = 1.38, 95% CI = 1.20-1.59), recessive (OR = 1.41, 95% CI = 1.23-1.61), dominant (OR = 1.47, 95% CI = 1.27-1.70), and allele (OR = 1.37, 95% CI = 1.23-1.52) genetic models. Stratified analysis demonstrated that C677T genotype was associated with T2DM in Asian populations, but not Caucasian and African populations.

conclusionOur results indicated that MTHFR C677T polymorphism confers to T2DM, especially in Asian populations. Much more large-scale case-control studies are needed to strengthen such conclusion in the future.

Indexed as

Polymorphism, Single NucleotideAsian PeopleDiabetes Mellitus, Type 2Genetic Association StudiesGenetic Predisposition to DiseaseGenotypeHumansMethylenetetrahydrofolate Reductase (NADPH2)Odds RatioMethylenetetrahydrofolate Reductase (NADPH2)MTHFR protein, humanC677Tmeta-analysisMTHFRpolymorphismT2DM

Identifiers

PMID31663297
PMCPMC6900375

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.