Evidence map›Paper›PMID 31663232›Full record

ArticleHuman brain mapping2020

Sensorimotor and pain-related alterations of the gray matter and white matter in Type 2 diabetic patients with peripheral neuropathy.

Youming Zhang, Minli Qu, Xiaoping Yi, Pei Zhuo, Jingyi Tang, Xin Chen, Gaofeng Zhou, Ping Hu, Ting Qiu, Wu Xing and 5 more

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Human brain mapping, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
31citing papers in PubMed, 1 pooled it
2.7field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

31 citing papers in PubMed, 1 synthesis or guideline pooled it, 50 citations in OpenAlex.

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  12. Novel insights into the nervous system affected by prolonged hyperglycemia.Journal of molecular medicine (Berlin, Germany) · 2023
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors at 2 institutions in 2 countries.

Youming ZhangDepartment of Radiology, Xiangya Hospital, Central South University, Changsha, China.ORCID 0000-0001-5350-2598
Minli QuDepartment of Endocrinology, Xiangya Hospital, Central South University, Changsha, China.
Xiaoping YiDepartment of Radiology, Xiangya Hospital, Central South University, Changsha, China.
Pei ZhuoDepartment of Radiology, Xiangya Hospital, Central South University, Changsha, China.
Jingyi TangDepartment of Radiology, Xiangya Hospital, Central South University, Changsha, China.
Xin ChenDepartment of Endocrinology, Xiangya Hospital, Central South University, Changsha, China.
Gaofeng ZhouDepartment of Radiology, Xiangya Hospital, Central South University, Changsha, China.
Ping HuDepartment of Radiology, Xiangya Hospital, Central South University, Changsha, China.
Ting QiuKey Laboratory for NeuroInformation of Ministry of Education, School of Life Science and Technology, University of Electronic Science and Technology of China, Chengdu, China.
Wu XingDepartment of Radiology, Xiangya Hospital, Central South University, Changsha, China.
Yitao MaoDepartment of Radiology, Xiangya Hospital, Central South University, Changsha, China.
Bihong T ChenDepartment of Diagnostic Radiology, City of Hope National Medical Center, Duarte, California.
Jing WuDepartment of Endocrinology, Xiangya Hospital, Central South University, Changsha, China.
Yuanchao ZhangKey Laboratory for NeuroInformation of Ministry of Education, School of Life Science and Technology, University of Electronic Science and Technology of China, Chengdu, China.ORCID 0000-0001-8191-4899
Weihua LiaoDepartment of Radiology, Xiangya Hospital, Central South University, Changsha, China.ORCID 0000-0002-1926-3527
Central South University · CNCity Of Hope National Medical Center · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Although diabetic peripheral neuropathy (DPN) has long been considered a disease of the peripheral nervous system, recent neuroimaging studies have shown that alterations in the central nervous system may play a crucial role in its pathogenesis. Here, we used surface-based morphometry (SBM) and tract-based spatial statistics (TBSS) to investigate gray matter (GM) and white matter (WM) differences between patients with DPN (n = 67, 44 painless and 23 painful) and healthy controls (HCs; n = 88). Compared with HCs, patients with DPN exhibited GM abnormalities in the pre- and postcentral gyrus and in several deep GM nuclei (caudate, putamen, medial pallidum, thalamus, and ventral nuclear). They also exhibited altered WM tracts (corticospinal tract, spinothalamic tract, and thalamocortical projecting fibers). These findings suggest impaired motor and somatosensory pathways in DPN. Further, patients with DPN (particularly painful DPN) exhibited morphological differences in the cingulate, insula, prefrontal cortex, and thalamus, as well as impaired WM integrity in periaqueductal WM and internal and external capsules. This suggests pain-perception/modulation pathways are altered in painful DPN. Intermodal correlation analyses found that the morphological indices of the brain regions identified by the SBM analysis were significantly correlated with the fractional anisotropy of brain regions identified by the TBSS analysis, suggesting that the GM and WM alterations were tightly coupled. Overall, our study showed sensorimotor and pain-related GM and WM alterations in patients with DPN, which might be involved in the development of DPN.

Indexed as

Motor ActivityAdultAgedCerebral CortexDiabetes Mellitus, Type 2Diabetic NeuropathiesFemaleGray MatterHumansMagnetic Resonance ImagingMaleMiddle AgedNeuralgiaNeural PathwaysNeuroimagingSomatosensory Disorderscortical thicknessdeep gray matter nucleidiabetic peripheral neuropathyshape analysissurface area

Identifiers

PMID31663232
PMCPMC7268085
OpenAlexW2982413677

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.