Evidence map›Paper›PMID 31663117›Full record

ArticleClinical and experimental immunology2020

Antibodies against neo-epitope of microbial and human transglutaminase complexes as biomarkers of childhood celiac disease.

D Agardh, T Matthias, P Wusterhausen, S Neidhöfer, A Heller, A Lerner

Open access · bronzeAbstract read
In one paragraph

Article in Clinical and experimental immunology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
1.3field-weighted citation impact, top 19% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 25 citations in OpenAlex.

  1. Article
  2. Article
  3. Review
  4. Article
  5. Article
  6. Review
  7. Review
  8. Article
  9. Review
  10. Review
  11. Article
  12. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 1 institution in 1 country.

D AgardhDiabetes and Celiac Disease Unit, Department of Clinical Sciences, Lund University, Malmö, Sweden.ORCID 0000-0003-1435-1234
T MatthiasAESKU.KIPP Institute, Wendelsheim, Germany.
P WusterhausenAESKU.KIPP Institute, Wendelsheim, Germany.
S NeidhöferAESKU.KIPP Institute, Wendelsheim, Germany.
A HellerAESKU.KIPP Institute, Wendelsheim, Germany.
A LernerAESKU.KIPP Institute, Wendelsheim, Germany.ORCID 0000-0002-6779-4090
Lund University · SE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Tissue transglutaminase (tTG) and microbial transglutaminase (mTG) cross-link gliadins to form complexes that expose immunogenic neo-epitopes to produce tTG and mTG-neo-epitope antibodies. The aim of this study was to test the diagnostic performance of antibodies against non-complexed and complexed forms of transglutaminases, to correlate their activities to the intestinal damage and to explore age group dependency in celiac disease (CD). A total of 296 children with untreated CD and 215 non-celiac disease controls were checked by in-house enzyme-linked immunosorbent assays detecting immunoglobulin (Ig)A, IgG or combined detection of IgA and IgG (check) against tTG, AESKULISA

Indexed as

AdolescentAutoantibodiesBacterial ProteinsBiomarkersCeliac DiseaseChildChild, PreschoolEnzyme-Linked Immunosorbent AssayEpitopesFemaleGliadinGTP-Binding ProteinsHumansImmunoglobulin AImmunoglobulin GInfantAutoantibodiesBacterial ProteinsBiomarkersEpitopesGliadinGTP-Binding ProteinsImmunoglobulin AImmunoglobulin GProtein Glutamine gamma Glutamyltransferase 2Transglutaminasesantibodiesautoantibodiesceliac diseasediagnosishuman tissue transglutaminasemicrobial transglutaminaseserological markers

Identifiers

PMID31663117
PMCPMC7008223
OpenAlexW2982518479

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.