Evidence map›Paper›PMID 31663080›Full record

ArticleMatter2019

An Antimicrobial Dental Light Curable Bioadhesive Hydrogel for Treatment of Peri-Implant Diseases.

Ehsan Shirzaei Sani, Roberto Portillo Lara, Zahra Aldawood, Seyed Hossein Bassir, Daniel Nguyen, Alpdogan Kantarci, Giuseppe Intini, Nasim Annabi

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Matter, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 39 papers.

0numbers the graph read from it
0cells of the map it votes in
39citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

39 citing papers in PubMed.

  1. Chiral FeBioactive materials · 2026
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  15. Nano selenium-doped TiOFrontiers in bioengineering and biotechnology · 2023
    Article
  16. Review
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  18. Review
  19. Cohesion mechanisms for bioadhesives.Bioactive materials · 2022
    Review
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Ehsan Shirzaei SaniChemical and Biomolecular Engineering Department, University of California -Los Angeles, Los Angeles, CA 90095, USA.
Roberto Portillo LaraTecnologico de Monterrey, Escuela de Ingeniería y Ciencias, Zapopan, JAL 44-49, México.
Zahra AldawoodDepartment of Oral Medicine, Infection, and Immunity, Harvard School of Dental Medicine, Boston, MA 02115, USA.
Seyed Hossein BassirDepartment of Oral Medicine, Infection, and Immunity, Harvard School of Dental Medicine, Boston, MA 02115, USA.
Daniel NguyenDepartment of Applied Oral Sciences, The Forsyth Institute, Cambridge, MA 02142, USA.
Alpdogan KantarciDepartment of Applied Oral Sciences, The Forsyth Institute, Cambridge, MA 02142, USA.
Giuseppe IntiniDepartment of Periodontics and Preventive Dentistry, University of Pittsburgh, School of Dental Medicine, Pittsburgh, PA 15213, USA.
Nasim AnnabiChemical and Biomolecular Engineering Department, University of California -Los Angeles, Los Angeles, CA 90095, USA.

Funding

Engineering highly elastic surgical sealants with hemostatic propertiesR01HL140618 · NHLBI · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI ANNABI, NASIM, KHADEMHOSSEINI, ALI · 2018 to 2021
$2.8M
Engineering a naturally derived and highly adhesive surgical sealantR01EB023052 · NIBIB · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI ANNABI, NASIM, KHADEMHOSSEINI, ALI · 2017 to 2022
$2.4M
NHLBI NIH HHS R01 HL140618NIBIB NIH HHS R01 EB023052
6 · The paper itself

Abstract

Dental implants constitute the standard of care to replace the missing teeth, which has led to an increase in the number of patients affected by peri-implant diseases (PIDs). Here, we report the development of an antimicrobial bioadhesive, GelAMP, for the treatment of PIDs. The hydrogel is based on a visible light-activated naturally-derived polymer (gelatin) and an antimicrobial peptide (AMP). The optimized formulation of GelAMP could be rapidly crosslinked using commercial dental curing systems. When compared to commercial adhesives, the bioadhesives exhibited significantly higher adhesive strength to physiological tissues and titanium. Moreover, the bioadhesive showed high cytocompatibility and could efficiently promote cell proliferation and migration

Indexed as

antimicrobial hydrogelsPeri-implant diseasestissue adhesive

Identifiers

PMID31663080
PMCPMC6818244

What OpenQuestion holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.