Evidence map›Paper›PMID 31663033›Full record

ArticleAIMS genetics2019

Alena V Malakhova, Olga I Rudko, Vladimir V Sobolev, Artemii V Tretiakov, Elena A Naumova, Zarema G Kokaeva, Julia E Azimova, Eugene A Klimov

Open access · diamondAbstract read
In one paragraph

Article in AIMS genetics, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed, 1 pooled it
0.3field-weighted citation impact, top 44% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 1 synthesis or guideline pooled it, 4 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Review
  4. Frontiers in genetics · 2021
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 4 institutions in 1 country.

Alena V MalakhovaLomonosov Moscow State University, Faculty of Biology, Moscow, Russia.
Olga I RudkoLomonosov Moscow State University, Faculty of Biology, Moscow, Russia.
Vladimir V SobolevI.I. Mechnikov Research Institute for Vaccines and Sera, Laboratory of molecular immunology, Moscow, Russia.
Artemii V TretiakovLomonosov Moscow State University, Faculty of Biology, Moscow, Russia.
Elena A NaumovaLomonosov Moscow State University, Faculty of Biology, Moscow, Russia.
Zarema G KokaevaLomonosov Moscow State University, Faculty of Biology, Moscow, Russia.
Julia E AzimovaUniversity headache clinic LLC, Moscow, Russia.
Eugene A KlimovLomonosov Moscow State University, Faculty of Biology, Moscow, Russia.
Lomonosov Moscow State University · RUConsultative and Diagnostic Center · RUResearch Institute of General Pathology and Pathophysiology, the Russian Academy of Medical Sciences · RURussian Academy of Sciences · RU

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundPanic disorder is a complex disease of unclear etiology but with an apparent genetic component.

aimsThe goal of our study was to evaluate the role of 3 SNPs in the

methods94 patients diagnosed with panic disorder according to the DSM-IV criteria were enrolled in the study. The population control group included 192 subjects. Genotyping was carried out by real-time PCR with TaqMan probes.

resultsThe investigated substitutions are not associated with panic disorder in general and in female/male cohorts (p > 0.05). The analysis of complex genotypes demonstrated two protective complex genotypes (rs1040716:A, T + rs10454453:A + rs502958:A and rs1040716:A, T + rs502958:A) associated with panic disorder in general regardless of the patient's gender (p < 0.05). These genotypes did not correlate with the patient's sex.

conclusionsWe found two complex protective genotypes associated with panic disorder. This can be due to the fact that predisposition to the disease are associated with other genes, while

Indexed as

genetic associationpanic disorderPDE4B geners1040716rs10454453rs502958

Identifiers

PMID31663033
PMCPMC6803789
OpenAlexW2969478063

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.