ArticleScience advances2019
Epigenetic dynamics in infancy and the impact of maternal engagement.
Article in Science advances, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05412524 (Impact of Reading on Endogenous Oxytocin System of Preterm Infants), which is not on this map. Cited by 45 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Impact of Reading on Endogenous Oxytocin System of Preterm Infants
Who cites it
45 citing papers in PubMed, 74 citations in OpenAlex.
- Maternal care is associated with neural and behavioral effects of oxytocin administration during empathic accuracy in schizophrenia and controls.Psychoneuroendocrinology · 2025Trial
- Variation in oxytocin receptor DNA methylation in female chickens are associated with age, genetics, laying intensity, and housing conditions.Poultry science · 2026Article
- SLC6A4 Gene Methylation in Premature Infants Undergoing Kangaroo Mother Care: A Prospective Longitudinal Study.Biomedicines · 2026Article
- An epigenetic framework for understanding contextual influences on neural and socio-emotional development: Narrative review and case-study of the oxytocin receptor.Developmental cognitive neuroscience · 2026Review
- Predicting Positive Affect in Infancy.Developmental science · 2026Article
- Experience-dependent maturation of somatosensory parvalbumin interneurons during social development in prairie voles.Cerebral cortex (New York, N.Y. : 1991) · 2026Article
- Parental behavior, adult attachment, and DNA methylation of the MT2 oxytocin receptor gene region - The moderating role of neuroticism.PloS one · 2026Article
- Exploring the relationship betweenFrontiers in psychology · 2026Article
- Prematurity and Epigenetic Regulation ofBiomedicines · 2025Article
- Epigenetics, Resilience, Protective Factors and Factors Promoting Positive Outcomes: A Scoping Review.International journal of developmental neuroscience : the official journal of the International Society for Developmental Neuroscience · 2025Article
- Dissecting the heterogeneity of autism spectrum disorder with sensory behavior, brain, and epigenetic factors.Translational psychiatry · 2025Article
- Interplay of plasma Oxytocin and oxytocin receptor gene methylation levels on empathy in older adults.Scientific reports · 2025Article
- The impact of the early environment on oxytocin receptor epigenetics and potential therapeutic implications.Pediatric research · 2025Review
- Grandmotherhood is associated with reduced OXTR DNA methylation.Psychoneuroendocrinology · 2024Article
- Critical Windows: Exploring the Association Between Perinatal Trauma, Epigenetics, and Chronic Pain.The Neuroscientist : a review journal bringing neurobiology, neurology and psychiatry · 2024Review
- Epigenetic regulation of the oxytocin system as an indicator of adaptation to over-controlling parenting and psychosocial functioning in adulthood.Psychoneuroendocrinology · 2024Article
- Is Oxytocin Induction at Labor a Risk Factor for Developmental Hip Dysplasia?Journal of clinical medicine · 2024Article
- Oxytocin Exhibits Neuroprotective Effects on Hippocampal Cultures under Severe Oxygen-Glucose Deprivation Conditions.Current issues in molecular biology · 2024Article
- Mother adversity and co-residence time impact mother-child similarity in genome-wide and gene-specific methylation profiles.Clinical epigenetics · 2024Article
- The relationships between the family impact and distress of the coronavirus disease-19 pandemic, parent insomnia, infant temperamental negative affectivity, and parent-reported infant sleep: a path analysis.Sleep advances : a journal of the Sleep Research Society · 2024Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 2 institutions in 2 countries.
Funding
Abstract
The contribution of nature versus nurture to the development of human behavior has been debated for centuries. Here, we offer a piece to this complex puzzle by identifying the human endogenous oxytocin system-known for its critical role in mammalian sociality-as a system sensitive to its early environment and subject to epigenetic change. Recent animal work suggests that early parental care is associated with changes in DNA methylation of conserved regulatory sites within the oxytocin receptor gene (
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.