ArticleScience advances2019
Cryo-electron microscopy structure and analysis of the P-Rex1-Gβγ signaling scaffold.
Open access · goldAbstract read
In one paragraph
Article in Science advances, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
0numbers the graph read from it
0cells of the map it votes in
24citing papers in PubMed
1.8field-weighted citation impact, top 14% of its field
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
24 citing papers in PubMed, 43 citations in OpenAlex.
- The Rho guanine-nucleotide exchange factor P-Rex2 exhibits structural and regulatory features distinct from the related RhoGEF P-Rex1.The Journal of biological chemistry · 2026Article
- P-Rex2 exhibits unique structural features and regulatory mechanisms distinct from the closely related RhoGEF P-Rex1.bioRxiv : the preprint server for biology · 2026Article
- Mutagenesis-Centered Integrative Approaches for Identifying Binding Sites in Ion Channels and Uncovering Modulatory Mechanisms.Advances in experimental medicine and biology · 2026Review
- Direct crosstalk between GPCRs and ion channels via G proteins.Experimental & molecular medicine · 2025Review
- P-Rex1 limits the agonist-induced internalization of GPCRs independently of its Rac-GEF activity.Cell reports · 2025Article
- Understanding P-Rex regulation: structural breakthroughs and emerging perspectives.Biochemical Society transactions · 2024Review
- New Mechanisms Underlying Oncogenesis in Dbl Family Rho Guanine Nucleotide Exchange Factors.Molecular pharmacology · 2024Review
- Molecular basis for Gβγ-mediated activation of phosphoinositide 3-kinase γ.Nature structural & molecular biology · 2024Article
- Structure of adenylyl cyclase 5 in complex with Gβγ offers insights into ADCY5-related dyskinesia.Nature structural & molecular biology · 2024Article
- Article
- Structural and dynamic changes in P-Rex1 upon activation by PIPbioRxiv : the preprint server for biology · 2024Article
- New biochemistry in the Rhodanese-phosphatase superfamily: emerging roles in diverse metabolic processes, nucleic acid modifications, and biological conflicts.NAR genomics and bioinformatics · 2023Article
- Cryo-EM structures of orphan GPR21 signaling complexes.Nature communications · 2023Article
- Quantitative analysis of protein dynamics using a deep learning technique combined with experimental cryo-EM density data and MD simulations.Biophysics and physicobiology · 2023Article
- Cryo-EM samples of gas-phase purified protein assemblies using native electrospray ion-beam deposition.Faraday discussions · 2022Article
- Structure of the metastatic factor P-Rex1 reveals a two-layered autoinhibitory mechanism.Nature structural & molecular biology · 2022Article
- GPCRs thatSmall GTPases · 2022Review
- Small-molecule inhibitors of P-Rex guanine-nucleotide exchange factors.Small GTPases · 2022Article
- Tools for visualizing and analyzing Fourier space sampling in Cryo-EM.Progress in biophysics and molecular biology · 2021Review
- Molecular basis for protein-protein interactions.Beilstein journal of organic chemistry · 2021Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
9 authors at 4 institutions in 1 country.
Jennifer N CashDepartment of Biological Chemistry & Life Sciences Institute, University of Michigan, Ann Arbor, MI, USA.ORCID 0000-0002-0277-7652
Sarah UrataDepartment of Medicine, University of California, San Diego, San Diego, CA, USA.ORCID 0000-0001-7512-4081
Sheng LiDepartment of Medicine, University of California, San Diego, San Diego, CA, USA.ORCID 0000-0002-9073-6809
Sandeep K RavalaDepartments of Biological Sciences and of Medicinal Chemistry and Molecular Pharmacology, Purdue University, West Lafayette, IN, USA.
Larisa V AvramovaDepartments of Biological Sciences and of Medicinal Chemistry and Molecular Pharmacology, Purdue University, West Lafayette, IN, USA.
Michael D ShostDepartment of Biological Chemistry & Life Sciences Institute, University of Michigan, Ann Arbor, MI, USA.ORCID 0000-0003-1833-0342
J Silvio GutkindDepartment of Pharmacology and Moores Cancer Center, University of California, San Diego, San Diego, CA, USA.ORCID 0000-0002-5150-4482
John J G TesmerDepartments of Biological Sciences and of Medicinal Chemistry and Molecular Pharmacology, Purdue University, West Lafayette, IN, USA.ORCID 0000-0003-1125-3727
Michael A CianfroccoDepartment of Biological Chemistry & Life Sciences Institute, University of Michigan, Ann Arbor, MI, USA.ORCID 0000-0002-2067-4999
Purdue University West Lafayette · USUniversity of Michigan · USUniversity of California San Diego · USUniversity of San Diego · US
Funding
Structure, function, and inhibition of G protein-coupled receptor kinasesR01HL071818 · NHLBI · UNIVERSITY OF TEXAS AUSTIN · PI TESMER, JOHN · 2004 to 2023
$7.1MStructure and Function of the LPLA2/LCAT Acyltransferase FamilyR01HL122416 · NHLBI · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI TESMER, JOHN · 2015 to 2018
$1.9MGPCR - Linked RhoGEFs in Tumor Growth and MetastasisR01CA221289 · NCI · PURDUE UNIVERSITY · PI TESMER, JOHN · 2018 to 2022
$1.9MSilicon Mechanics Compute ClusterS10OD020011 · OD · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI SKINIOTIS, GEORGIOS · 2015 to 2015
$490kNCI NIH HHS R01 CA221289NHLBI NIH HHS R01 HL071818NHLBI NIH HHS R01 HL122416NIH HHS S10 OD020011
Abstract
PIP
Indexed as
Amino Acid SequenceBinding SitesCell MembraneCell MovementCryoelectron MicroscopyGuanine Nucleotide Exchange FactorsHumansProtein BindingProtein DomainsPTEN PhosphohydrolaseSequence AlignmentSignal TransductionGuanine Nucleotide Exchange FactorsPREX1 protein, humanPTEN Phosphohydrolase
Identifiers
What OpenQuestion holds
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LicenceCC BY
Read underepoch 390
Registered trials
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.