ReviewScience advances2019
The treatment of cocaine use disorder.
Review in Science advances, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 124 papers, 6 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
124 citing papers in PubMed, 6 syntheses or guidelines pooled it, 242 citations in OpenAlex.
- Pooled it
- Effects of different exercise types on craving in substance use disorder patients with drug dependence -network meta-analysis and dose-response relationships based on frequentist and Bayesian models.Addiction science & clinical practice · 2025Pooled it
- Prevalence of Dropout and Influencing Factors in Digital Psychosocial Intervention Trials for Adult Illicit Substance Users: Systematic Review and Meta-Analysis.Journal of medical Internet research · 2025Pooled it
- Peripheral neurotrophin levels during controlled crack/cocaine abstinence: a systematic review and meta-analysis.Scientific reports · 2024Pooled it
- Prescription psychostimulants for the treatment of stimulant use disorder: a systematic review and meta-analysis.Psychopharmacology · 2020Pooled it
- The Evolving Overdose Epidemic: Synthetic Opioids and Rising Stimulant-Related Harms.Epidemiologic reviews · 2020Pooled it
- Attenuating trauma- and cocaine-related intrusions by blocking memory reconsolidation with minocycline: protocol for a transdiagnostic randomized controlled trial.European journal of psychotraumatology · 2026Trial
- Quality-of-life improvements associated with reductions in cocaine-positive urine drug screens.Psychology of addictive behaviors : journal of the Society of Psychologists in Addictive Behaviors · 2026Trial
- A single-blind, randomized, controlled contingency management trial on physiological indices and biomarkers of cardiovascular health in people with cocaine use disorder.Drug and alcohol dependence · 2025Trial
- A randomized clinical trial of disulfiram at higher doses for the treatment of cocaine use disorder among methadone-stabilized patients.Journal of psychiatric research · 2025Trial
- Vitamin D's Capacity to Increase Amphetamine-Induced Dopamine Release in Healthy Humans: A Clinical Translational [Biological psychiatry · 2025Trial
- The role of Iowa gambling task performance in response to citalopram treatment for cocaine use disorder.The American journal of drug and alcohol abuse · 2025Trial
- Influence of cocaine use reduction on markers of immune function.Journal of neuroimmunology · 2024Trial
- Examining cocaine use reductions and long-term outcomes in two clinical trials of continuing care for cocaine dependence.Journal of substance use and addiction treatment · 2024Trial
- Cortical and subcortical microstructure integrity changes after repetitive transcranial magnetic stimulation therapy in cocaine use disorder and relates to clinical outcomes.Addiction biology · 2024Trial
- Repeated measures latent class analysis identifies unique daily cocaine-use patterns and associated clinical characteristics: A timeline followback-based analytic approach.Drug and alcohol dependence reports · 2026Article
- Substance-related intrusive memories in cocaine use disorder are different from but associated with craving.Addiction (Abingdon, England) · 2026Article
- Preliminary Evidence of Inhibitory and Error-Related Neural Alterations Associated with Early Relapse in Cocaine Use Disorder: A Retrospective Go/No-Go Event-Related Potential Study.European addiction research · 2026Article
- Service utilization patterns in cocaine use disorder: A data-driven study.Drug and alcohol dependence reports · 2026Article
- The role of nucleus accumbens Fos expression in sex-dependent cocaine-induced locomotion, cocaine self-administration, and primed cocaine seeking in rats.Behavioural brain research · 2026Article
64 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
1 author at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Cocaine use continues to be a serious worldwide public health problem. Cocaine abuse is associated with substantial morbidity and mortality. Cocaine overdose deaths are increasing in the United States and, in certain populations, outnumber heroin and opiate overdose deaths. Psychosocial treatments remain the treatments of choice for cocaine use disorder (CUD), with standard approaches including contingency management and cognitive behavioral therapy. However, the effect sizes of these treatments are not large, and they are not effective for most patients. Consequently, investigators have sought to develop pharmacological agents to augment the efficacy of psychosocial treatments. Despite these efforts, no medications have yet been proven to be safe and effective for the treatment of CUD. The most promising pharmacological strategies for CUD treatment thus far include the use of dopamine agonists, such as long-acting amphetamine and modafinil or glutamatergic and GABAergic agents such as topiramate. Combination drugs may be especially promising.
Indexed as
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.