ReviewJournal of thyroid research2019
Challenges in Interpreting Thyroid Stimulating Hormone Results in the Diagnosis of Thyroid Dysfunction.
Review in Journal of thyroid research, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 39 papers, 2 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
39 citing papers in PubMed, 2 syntheses or guidelines pooled it, 87 citations in OpenAlex.
- Effectiveness of low dose thyroxine in patients with subclinical hypothyroidism and migraine; systematic review and meta-analysis.BMC neurology · 2025Pooled it
- Effect of levothyroxine replacement therapy in patients with subclinical hypothyroidism and chronic heart failure: A systematic review.Frontiers in endocrinology · 2022Pooled it
- Clinical insights into levothyroxine overdose: A systematic review.World journal of methodology · 2026Article
- Detection of previously undiagnosed conditions in midlife preventive health examinations.Scientific reports · 2026Article
- Spectral Super-Resolution Colloidal SERS Spectroscopy for Multiplexed Detection of Protein Biomarkers.Nano letters · 2026Article
- Understanding the Drivers of Hypothyroidism in Patients Undergoing Chronic Hemodialysis.Diagnostics (Basel, Switzerland) · 2026Article
- Causal Association Between Thyroid Function and Myeloproliferative Disease: A Two-Sample Mendelian Randomization Study.International journal of endocrinology · 2026Article
- Waist circumference versus BMI: A cross-sectional study comparing Cardiometabolic Risk association in the Nepalese Population.PloS one · 2026Article
- Impact of Tamoxifen on Endometrial Thickness in Women With Thin Endometrium Following Estrogen Therapy During Frozen-Thawed Embryo Transfer.Clinical case reports · 2025Article
- Review
- Review
- Hypothyroidism: playing the cardiometabolic risk concerto.Thyroid research · 2025Review
- Women-specific reference ranges for serum TSH in Liguria: the impact of age and year of collection in a single-center cross-sectional study.Thyroid research · 2025Article
- Magnitude, Pattern, and Associated Factors of Thyroid Dysfunction in Diabetic Patients at Debre Markos Referral Hospital in North-West Ethiopia: A Cross-Sectional Hospital-based Study.Ethiopian journal of health sciences · 2025Article
- Knowledge gaps about the diagnosis and treatment of hypothyroidism: an international patient survey.Frontiers in endocrinology · 2025Article
- Persistent symptoms in euthyroid Hashimoto's thyroiditis: current hypotheses and emerging management strategies.Frontiers in endocrinology · 2025Review
- SDIMMMER: A Proposed Clinical Approach to Optimize Cellular Physiology in Regenerative Medicine.Life (Basel, Switzerland) · 2024Article
- Article
- Update on therapeutic use of levothyroxine for the management of hypothyroidism during pregnancy.Endocrine connections · 2024Review
- Atypical Thyroid Stimulating Hormone Levels in Myxedema Coma Complicated by Severe Sepsis.Journal of community hospital internal medicine perspectives · 2024Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 3 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The pituitary hormone, thyrotropin (TSH), is regarded as the primary biomarker for evaluating thyroid function and is useful in guiding treatment with levothyroxine for patients with hypothyroidism. The amplified response of TSH to slight changes in thyroid hormone levels provides a large and easily measured signal in the routine care setting. Laboratories provide reference ranges with upper and lower cutoffs for TSH to define normal thyroid function. The upper limit of the range, used to diagnose subclinical (mild) hypothyroidism, is itself a matter for debate, with authoritative guidelines recommending treatment to within the lower half of the range. Concomitant diseases, medications, supplements, age, gender, ethnicity, iodine status, time of day, time of year, autoantibodies, heterophilic antibodies, smoking, and other factors influence the level of TSH, or the performance of current TSH assays. The long-term prognostic implications of small deviations of TSH from the reference range are unclear. Correction of TSH to within the reference range does not always bring thyroid and other biomarkers into range and will not always resolve the patient's symptoms. Overt hypothyroidism requires intervention with levothyroxine. It remains important that physicians managing a patient with symptoms suggestive of thyroid disease consider all of the patient's relevant disease, lifestyle, and other factors before intervening on the basis of a marginally raised TSH level alone. Finally, these limitations of TSH testing mitigate against screening the population for the undoubtedly substantial prevalence of undiagnosed thyroid disease, until appropriately designed randomised trials have quantified the benefits and harms from this approach.
Identifiers
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.