Evidence map›Paper›PMID 31662773›Full record

ReviewEvidence-based complementary and alternative medicine : eCAM2019

Wound Healing and the Use of Medicinal Plants.

Aleksandra Shedoeva, David Leavesley, Zee Upton, Chen Fan

Abstract readReview
In one paragraph

Review in Evidence-based complementary and alternative medicine : eCAM, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 134 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
134citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

134 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Trial
  3. Article
  4. Integrating in vivo and in silico: a comprehensive study of Helix aspersa mucin's therapeutic properties.International microbiology : the official journal of the Spanish Society for Microbiology · 2026
    Article
  5. Article
  6. Article
  7. Article
  8. Review
  9. Evaluation ofMedical sciences (Basel, Switzerland) · 2026
    Article
  10. Review
  11. Anti-Obesity Activity of GiantInternational journal of molecular sciences · 2026
    Article
  12. Enhancing Wound Healing with a Novel Alginate/Eggshell Membrane-Based Hydrogel Enriched with Red Ginseng Roots and Centella Asiatica.Skin research and technology : official journal of International Society for Bioengineering and the Skin (ISBS) [and] International Society for Digital Imaging of Skin (ISDIS) [and] International Society for Skin Imaging (ISSI) · 2026
    Article
  13. Article
  14. Verbascoside-richFrontiers in bioengineering and biotechnology · 2026
    Article
  15. Article
  16. Article
  17. Review
  18. Review
  19. Protective Effect of Peony (Molecules (Basel, Switzerland) · 2025
    Article
  20. Review

74 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Aleksandra ShedoevaSkin Research Institute of Singapore, Agency for Science, Technology and Research, A∗STAR, 11 Mandalay Road, Singapore 308232.ORCID https://orcid.org/0000-0002-9019-1466
David LeavesleySkin Research Institute of Singapore, Agency for Science, Technology and Research, A∗STAR, 11 Mandalay Road, Singapore 308232.ORCID https://orcid.org/0000-0002-1033-5459
Zee UptonSkin Research Institute of Singapore, Agency for Science, Technology and Research, A∗STAR, 11 Mandalay Road, Singapore 308232.ORCID https://orcid.org/0000-0002-9928-5864
Chen FanSkin Research Institute of Singapore, Agency for Science, Technology and Research, A∗STAR, 11 Mandalay Road, Singapore 308232.ORCID https://orcid.org/0000-0002-6509-6176

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Cutaneous wound healing is the process by which skin repairs itself. It is generally accepted that cutaneous wound healing can be divided into 4 phases: haemostasis, inflammation, proliferation, and remodelling. In humans, keratinocytes re-form a functional epidermis (reepithelialization) as rapidly as possible, closing the wound and reestablishing tissue homeostasis. Dermal fibroblasts migrate into the wound bed and proliferate, creating "granulation tissue" rich in extracellular matrix proteins and supporting the growth of new blood vessels. Ultimately, this is remodelled over an extended period, returning the injured tissue to a state similar to that before injury. Dysregulation in any phase of the wound healing cascade delays healing and may result in various skin pathologies, including nonhealing, or chronic ulceration. Indigenous and traditional medicines make extensive use of natural products and derivatives of natural products and provide more than half of all medicines consumed today throughout the world. Recognising the important role traditional medicine continues to play, we have undertaken an extensive survey of literature reporting the use of medical plants and plant-based products for cutaneous wounds. We describe the active ingredients, bioactivities, clinical uses, formulations, methods of preparation, and clinical value of 36 medical plant species. Several species stand out, including

Identifiers

PMID31662773
PMCPMC6778887

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.